Method and composition for removing uremic toxins in dialysis processes
First Claim
Patent Images
1. A device for removing uremic toxins in a dialysis procedure comprising:
- a body having an inlet and an outlet and defining an interior, the interior including a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon; and
the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the urease or the zirconium oxide layer.
1 Assignment
0 Petitions
Accused Products
Abstract
Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.
-
Citations
16 Claims
-
1. A device for removing uremic toxins in a dialysis procedure comprising:
-
a body having an inlet and an outlet and defining an interior, the interior including a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon; and the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the urease or the zirconium oxide layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
-
12. A device for removing uremic toxins in a dialysis procedure comprising:
-
a body having an inlet and an outlet and defining an interior, the interior including a layer comprising a modified urease selected from the group consisting of cross-linked enzyme crystals of urease, a blend of urease and zirconium oxide, and alumina-stabilized urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon; and the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the modified urease or the zirconium oxide layer. - View Dependent Claims (13, 14)
-
-
15. A device for removing uremic toxins in a dialysis procedure comprising:
a body having an inlet and an outlet and defining an interior, the interior including a layer comprising a modified urease selected from the group consisting of cross-linked enzyme crystals of urease, a blend of urease and zirconium oxide, and alumina-stabilized urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon wherein the modified urease is an irradiated modified urease.
-
16. A device for removing uremic toxins in a dialysis procedure comprising:
a body having an inlet and an outlet and defining an interior, the interior including a layer comprising a modified urease selected from the group consisting of cross-linked enzyme crystals of urease, a blend of urease and zirconium oxide, and alumina-stabilized urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon wherein the modified urease is a blend of urease and zirconium oxide, the urease present from about 0.1% to about 0.2% by weight of the blend.
Specification