Aneurysm stent with growth factor

• US 7,241,301 B2
• Filed: 10/06/2003
• Issued: 07/10/2007
• Est. Priority Date: 08/19/2002
• Status: Active Grant

• Current Assignee: Jefrey Thramann
• Original Assignee: Jeffrey Thramann
• Inventors: Thramann, Jeffrey J., Fulton, Michael
• Primary Examiner(s): TRUONG, KEVIN THAO
• Application Number:
  US10/680,063
• Publication Number:
  US 20040106945A1
• Time in Patent Office: 1,373 Days
• Field of Search: 606/108, 606/151, 606/157, 606/158, 606/191, 606/194, 606/195, 606/198, 606/200, 623/1.11, 623/1.12, 623/1.2
• US Class Current: 606/157
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 2017/00867 shape memory effect
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/12068 detachable by heat
• CPC Class Codes: A61F 2/852 Two or more distinct overlapping stents
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2002/30329 Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
• CPC Class Codes: A61F 2002/30545 for adjusting a diameter
• CPC Class Codes: A61F 2002/30599 stackable
• CPC Class Codes: A61F 2002/826 more than one stent being applied sequentially
• CPC Class Codes: A61F 2002/828 Means for connecting a plurality of stents allowing flexibility of the whole structure
• CPC Class Codes: A61F 2002/91508 the meander having a difference in amplitude along the band
• CPC Class Codes: A61F 2002/91525 within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91541 : Adjacent bands are arranged out of phase
• CPC Class Codes: A61F 2002/91558 : connected peak to peak
• CPC Class Codes: A61F 2002/91575 : connected peak to trough
• CPC Class Codes: A61F 2002/91591 : Locking connectors, e.g. using male-female connections
• CPC Class Codes: A61F 2002/9665 : with additional retaining means
• CPC Class Codes: A61F 2220/0025 : Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
• CPC Class Codes: A61F 2230/0095 : Saddle-shaped
• CPC Class Codes: A61F 2250/001 : for adjusting a diameter
• CPC Class Codes: A61F 2250/0063 : Nested prosthetic parts
• CPC Class Codes: A61F 2250/0071 : breakable or frangible

Abstract

The present invention relates to an aneurysm stent having a base and connector. The base has a vessel facing side and an aneurysm facing side, and is shaped to cover an aneurysm sufficiently. The connector is coupled to the aneurysm facing side of the base such that when deployed the connector is adapted to extend partially into the aneurysm to anchor the base about the aneurysm and alter flow into the aneurysm. Further, the stent can be used as a delivery mechanism to deliver growth factor.

Claims

1. An apparatus deployable in a blood vessel to alter flow to an aneurysm packed with aneurysm coils, comprising:

a base having a vessel facing side and an aneurysm facing side;

the base comprising a shape sufficient to substantially cover a neck of the aneurysm, the base adapted to reside in the vessel;

a connector;

the connector formed as a coil and adapted to connect to the aneurysm coils separately packed into the aneurysm;

at least one of the base or the connector comprising a carrier, a binder, and a growth factor; and

the connector coupled to at leas tone of the aneurysm facing side and the vessel facing side,

wherein the connector anchors the base about the neck of the aneurysm to alter flow about the aneurysm and allow flow through the vessel.

2. The apparatus according to claim 1, wherein:

the base comprises graft material.

3. The apparatus according to claim 1, wherein:

the base comprises self-expanding material such that the base can be delivered in a small package and expands on deployment to cover the neck of the aneurysm.

4. The apparatus according to claim 3, wherein the base also comprises graft material.

5. The apparatus according to claim 1, wherein the at least one coil is deformed such that on activation the at least one coil engages the aneurysm coils packed in the aneurysm to provide a force tending to seat the base about the neck of the aneurysm.

6. The apparatus according to claim 1, wherein only the at least one coil is a growth and comprises a carrier, a binder, and a growth factor.

7. The apparatus according to claim 6, wherein the carrier is polyvinyl alcohol (PVA).

8. The apparatus of claim 6, wherein the carrier is polyethylene terephthalate (PET).

9. The apparatus according to claim 6, wherein the binder is acidic gelatin hydrogel.

10. The apparatus according to claim 6, wherein the growth factor is basic fibroblast growth factor (bFGF).

11. The apparatus according to claim 6, wherein the growth factor is transferring growth factor.

12. The apparatus according to claim 6, wherein the growth factor is vascular endothelial growth factor.

13. The apparatus according to claim 1, wherein only the base comprises the carrier, the binder, and the growth factor.

14. The apparatus according to claim 13, wherein the carrier is polyvinyl alcohol (PVA).

15. The apparatus of claim 13, wherein the carrier is polyethylene terephthalate (PET).

16. The apparatus according to claim 13, wherein the binder is acidic gelatin hydrogel.

17. The apparatus according to claim 13, wherein the growth factor is basic fibroblast growth factor (bFGF).

18. The apparatus according to claim 13, wherein the growth factor is transferring growth factor.

19. The apparatus according to claim 13, wherein the growth factor is vascular endothelial growth factor.

20. The apparatus according to claim 13, wherein the base comprises a coil that is arranged in the shape of a spiral.

21. The apparatus according to claim 20, wherein the base coil comprises a shaped memory alloy that is activated on thermal manipulation.

22. The apparatus according to claim 1, wherein only the vessel facing side of the base comprises a carrier, a binder, and a growth factor.

23. The apparatus according to claim 22, wherein the carrier is polyvinyl alcohol (PVA).

24. The apparatus of claim 22, wherein the carrier is polyethylene terephthalate (PET).

25. The apparatus according to claim 22, wherein the binder is acidic gelatin hydrogel.

26. The apparatus according to claim 25, wherein the growth factor is basic fibroblast growth factor (bFGF).

27. The apparatus according to claim 22, wherein the growth factor is transferring growth factor.

28. The apparatus according to claim 22, wherein the growth factor is vascular endothelial growth factor.

29. The apparatus according to claim 1, wherein only the aneurysm facing side of the base comprises a carrier, a binder, and a growth factor.

30. The apparatus according to claim 29, wherein the carrier is polyvinyl alcohol (PVA).

31. The apparatus of claim 29, wherein the carrier is polyethylene terephthalate (PET).

32. The apparatus according to claim 29, wherein the binder is acidic gelatin hydrogel.

33. The apparatus according to claim 29, wherein the growth factor is basic fibroblast growth factor (bFGF).

34. The apparatus according to claim 29, wherein the growth factor is transferring growth factor.

35. The apparatus according to claim 29, wherein the growth factor is vascular endothelial growth factor.

36. A method for obstructing the flow of blood through the neck of an aneurysm packed with aneurysm coils, the method comprising the steps of:

selecting an aneurysm base comprising a carrier, a binder, and a growth factor of sufficient size to substantially cover the neck of the aneurysm

passing a catheter to the site of the aneurysm;

inserting an anchor into the aneurysm;

deploying the aneurysm base to substantially cover the neck of the aneurysm in a blood vessel to substantially block the neck of the aneurysm; and

anchoring the aneurysm base about the neck of the aneurysm by packing the anchor into the aneurysm coils separately packed in the aneurysm to alter the flow of blood to the aneurysm and allow flow through the vessel.

37. An aneurysm stent, comprising:

a base of sufficient size to substantially cover a neck of an aneurysm to reside in a blood vessel, the base comprising a carrier, a binder, and a growth factor;

at least one connector coupled to the base;

the at least one connector comprising at least one coil to pack into aneurysm coils separately packed in an aneurysm; and

the at least one connector to be inserted into the aneurysm and, upon insertion, to anchor the base about a neck of the aneurysm without blocking the vessel.

38. The aneurysm stent according to claim 37, wherein the at least one connector comprises:

the at least one coil being tightly wound and extending from the base through the aneurysm neck and into the aneurysm;

the at least one tightly wound coil expands after insertion to pack the aneurysm and anchor the stent.