Vascular prosthesis and method for production thereof

• US 7,244,272 B2
• Filed: 02/14/2005
• Issued: 07/17/2007
• Est. Priority Date: 12/19/2000
• Status: Expired due to Term

• Current Assignee: Nicast Ltd.
• Original Assignee: Nicast Ltd.
• Inventors: Bar, Eli, Dubson, Alexander
• Primary Examiner(s): Stewart; Alvin J.
• Assistant Examiner(s): Izquierdo; David A.
• Application Number:
  US11/056,151
• Publication Number:
  US 20050137675A1
• Time in Patent Office: 883 Days
• Field of Search: 623 112- 115
• US Class Current: 623/1.44
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2250/0023 differing in porosity
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: B29C 67/20 for porous or cellular articles, e.g. of foam plastics, coarse-pored chemical aspects of working up macro-molecular substances to porous or cellular articles C08J9/00
• CPC Class Codes: D01D 5/0038 the fibre formed by solvent evaporation, i.e. dry electro-spinning
• CPC Class Codes: D01D 5/0092 characterised by the electrical field, e.g. combined with a magnetic fields, using biased or alternating fields
• CPC Class Codes: D01F 1/10 Other agents for modifying properties
• CPC Class Codes: D01F 6/70 from polyurethanes
• CPC Class Codes: D04H 1/728 by electro-spinning electro-spinning methods and apparatus D01D5/0007
• CPC Class Codes: D04H 3/07 otherwise than in a plane, e.g. in a tubular way
• CPC Class Codes: D04H 3/073 Hollow cylinder shaped
• CPC Class Codes: D04H 3/16 with bonds between thermoplastic filaments produced in association with filament formation, e.g. immediately following extrusion

Abstract

A vascular prosthesis comprising a first layer having a predetermined first porosity and a second layer having a predetermined second porosity, wherein the first layer and the second layer are each made of first and second electrospun polymer fibers.

Claims

1. A vascular prosthesis comprising:

a first layer, made of electrospun polymer fibers and having a predetermined first porosity,

a second layer, made of electrospun polymer fibers and having a predetermined second porosity being higher than said predetermined first porosity, and

at least one intermediate layer, made of electrospun polymer fibers and being interposed between said first layer and said second layer;

wherein the electrospun polymer fibers of at least one of said first layer and said second layer are oriented predominantly transversely, and the electrospun polymer fibers of at least one of said at least one intermediate layer are oriented randomly.

2. The vascular prosthesis of claim 1, wherein said at least one intermediate layer comprises at least one coiled pattern.

3. The vascular prosthesis of claim 2, wherein said coiled pattern is formed from a wound filament.

4. The vascular prosthesis of claim 2, wherein said coiled pattern is embodied within said first layer.

5. The vascular prosthesis of claim 2, wherein said coiled pattern is embodied within said second layer.

6. The vascular prosthesis of claim 2, wherein said at least one intermediate layer includes a plurality of adhesion sublayers, alternately interposed between said first layer and said coiled pattern, between said coiled pattern and said second layer, and between two congruent coiled patterns.

7. The vascular prosthesis of claim 1, wherein each of said first layer and said second layer independently includes at least one drug incorporated therein, for delivery of said at least one drug into a body vasculature during or after implantation of the vascular prosthesis within said body vasculature.

8. the vascular prosthesis of claim 1, wherein said at least on intermediate layer includes at least one drug incorporated therein for delivery of said at least one drug into a body vasculature during or after implantation of the vascular prosthesis within said body vasculature.