One-dimensional arrays on optical fibers
First Claim
1. A chemical testing apparatus comprising:
- an optical fiber providing a linear support conducting light along a length between two ends; and
a combinatorial library of probe compounds attached at discrete locations along the length of the optical fiber in a predetermined pattern, the probe compounds positioned to be exposed to target compounds applied to the optical fiber.
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Accused Products
Abstract
Linear arrays of chemosensors or chemical compounds are supported by an optical fiber that allows one to rapidly assay the entire array using changes in optical properties such as fluorescence. The location of the agent along the fiber determines the identity of the agent in these linear arrays. Combinatorial libraries may be constructed on the fiber as well as assayed on the optical fiber. A system and method of analyzing the entire array of agents on an optical fiber using a light source, an optical fiber, and a detector are also described. The time delay between the excitation and detection determines the location being assayed along the fiber and therefore the identity of the agent being assayed. The present invention may find uses in the medical, pharmaceutical, environmental, defense, and food industries.
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Citations
16 Claims
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1. A chemical testing apparatus comprising:
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an optical fiber providing a linear support conducting light along a length between two ends; and a combinatorial library of probe compounds attached at discrete locations along the length of the optical fiber in a predetermined pattern, the probe compounds positioned to be exposed to target compounds applied to the optical fiber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of testing an analyte having target compounds, the method comprising the steps of:
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(a) preparing an optical fiber with a combinatorial library of probe compounds attached at discrete locations along the length of the optical fiber in a predetermined pattern; (b) exposing the prepared optical fiber to target compounds in an analyte; and (c) photometrically analyzing the exposed and prepared optical fibers to detect reaction of the probe compounds with the target compounds from the analyte. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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Specification