Apparatus for monitoring a system with time in space and method for diagnosing a condition of a prostate
DCFirst Claim
1. Apparatus for monitoring a human body in which a fluid flows and which is characterized by a change in the system with time in space for determining a prostate condition for diagnosing cancer comprising:
- (a) monitoring means for monitoring a preselected place in a human body for collecting data indicative of a parameter of the prostate that varies with time as a function of at least one variable related to wash-in and wash-out behavior;
(b) first data processing means responsive to the monitoring means for receiving the collected data and processing same;
(c) selecting means for controlling the monitoring means for setting parameters of data collection, and for receiving inputs of body parameters including said prostate parameter and a plurality of time points correlated to a body event;
(d) second data processing means including;
(1) grid means for dividing the space defined by the at least two variables, each ranging from a minimum to a maximum, into a grid;
(2) first determining means for determining for each grid location a calculated value and intensity function indicative of the wash-in of the parameter being monitored for each time point;
(3) first normalizing means for determining a grid location of maximum intensity and normalizing all grid locations with reference to the maximum;
(4) first colorizing means for coloring all grid locations one of a plurality of colors based on a color function indicative of wash-out behavior;
(5) arranging means for arranging all grid locations for all time points into a composite to develop a calibration map of the grid with each grid location correlated to a color hue/color intensity;
(6) analyzing means for analyzing the calibration map to determine if the attributes of the calibration map meet a preselected standard and, if not, to implement the plurality of time points or a body parameter and iterate until the resultant calibration map meets said standard;
(e) said first data processing means receiving as further inputs the plurality of time points and the maximum of the intensity function as determined in the second data processing means and further including;
(1) division means for spatially dividing the preselected place in the system into spatial units;
(2) second determining means for determining for each spatial unit a value and intensity function indicative of wash-in behavior based on the collected data for each time point;
(3) second normalizing means for normalizing the intensity of each spatial unit based on maximum intensity obtained from the first normalizing means;
(4) second colorizing means for coloring all spatial units one of a plurality of colors based on the color function indicative of wash-out behavior of said first colorizing means;
(5) arranging means for arranging all spatial units for all time points into a composite of the preselected space with each spatial unit correlated to a color hue/color intensity.
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Abstract
Apparatus and method for monitoring a prostate in a human body in which a fluid flows and which is characterized by a change in the prostate with time in space for the purpose of diagnosing a prostate condition, particularly cancer. A preselected place in the prostate is monitored to collect data at two or more time points correlated to a prostate event. The data is indicative of a prostate parameter that varies with time as a function of at least two variables related to prostate wash-in and wash-out behavior. A calibration map is made on a calculated basis with each pixel or voxel representative of a color hue indicative of wash-out behavior and a color intensity indicative of wash-in behavior. When a satisfactory map is obtained, the collected data is processed on the basis of the map to obtain an image of the preselected place with each spatial unit thereof correlated with a color hue and a color intensity. Software and a data processing system are provided to develop the calibration map. The calibration map and image of the preselected place are also novel implementations.
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Citations
36 Claims
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1. Apparatus for monitoring a human body in which a fluid flows and which is characterized by a change in the system with time in space for determining a prostate condition for diagnosing cancer comprising:
- (a) monitoring means for monitoring a preselected place in a human body for collecting data indicative of a parameter of the prostate that varies with time as a function of at least one variable related to wash-in and wash-out behavior;
(b) first data processing means responsive to the monitoring means for receiving the collected data and processing same;
(c) selecting means for controlling the monitoring means for setting parameters of data collection, and for receiving inputs of body parameters including said prostate parameter and a plurality of time points correlated to a body event;
(d) second data processing means including;
(1) grid means for dividing the space defined by the at least two variables, each ranging from a minimum to a maximum, into a grid;
(2) first determining means for determining for each grid location a calculated value and intensity function indicative of the wash-in of the parameter being monitored for each time point;
(3) first normalizing means for determining a grid location of maximum intensity and normalizing all grid locations with reference to the maximum;
(4) first colorizing means for coloring all grid locations one of a plurality of colors based on a color function indicative of wash-out behavior;
(5) arranging means for arranging all grid locations for all time points into a composite to develop a calibration map of the grid with each grid location correlated to a color hue/color intensity;
(6) analyzing means for analyzing the calibration map to determine if the attributes of the calibration map meet a preselected standard and, if not, to implement the plurality of time points or a body parameter and iterate until the resultant calibration map meets said standard;
(e) said first data processing means receiving as further inputs the plurality of time points and the maximum of the intensity function as determined in the second data processing means and further including;
(1) division means for spatially dividing the preselected place in the system into spatial units;
(2) second determining means for determining for each spatial unit a value and intensity function indicative of wash-in behavior based on the collected data for each time point;
(3) second normalizing means for normalizing the intensity of each spatial unit based on maximum intensity obtained from the first normalizing means;
(4) second colorizing means for coloring all spatial units one of a plurality of colors based on the color function indicative of wash-out behavior of said first colorizing means;
(5) arranging means for arranging all spatial units for all time points into a composite of the preselected space with each spatial unit correlated to a color hue/color intensity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- (a) monitoring means for monitoring a preselected place in a human body for collecting data indicative of a parameter of the prostate that varies with time as a function of at least one variable related to wash-in and wash-out behavior;
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10. Apparatus for monitoring a prostate in a human body in which a fluid flows and which is characterized by a change in the prostate with time in space comprising:
- (a) monitoring means including a first output for monitoring a preselected place in the prostate for collecting data indicative of a parameter that varies with time as a function of at least two variables related to wash-in and wash-out behavior, (b) first processing means including a second output and a first input for receiving the collected data from the first output and processing same, (c) selecting means including a third output for controlling the monitoring means, for setting parameters of data collection and for providing input to the first input, the selecting means including;
(i) input means for receiving inputs of parameters including said parameter and a plurality of preselected time points correlated to an event, (ii) a second processing means including;
(1) grid means for dividing the space defined by the at least two variables, each ranging from a minimum to a maximum, into a grid, (2) first determining means for determining for each grid location a calculated value of intensity of the parameter being monitored for each time point, (3) first normalizing means for determining the maximum intensity of the grid locations and normalizing all grid locations with reference to the maximum, (4) first colorizing means for coloring all grid locations one of a plurality of colors based on a correlation with wash-out behavior, (5) arranging means for arranging all grid locations for all time points into a composite to develop a calibration map of the grid with each grid location correlated to a color hue/color intensity, (6) analyzing means for analyzing the calibration map to determine if the color distribution of the calibration map satisfies a predetermined condition and, if not, to implement one of the plurality of time points and a parameter and inputting to the input means for iteration until the resultant calibration map satisfies the predetermined condition, (d) said first processing means receiving as further inputs the plurality of time points and the maximum of the intensity function as determined in the second processing means, and further including;
(i) division means for spatially dividing the preselected place in the prostate into spatial units, (ii) second determining means for determining for each spatial unit a value and intensity based on the collected data for each time point, (iii) second normalizing means for normalizing the intensity of each spatial unit based on maximum intensity obtained from the first normalizing means, (iv) second colorizing means for coloring all spatial units one of a plurality of colors based on the correlation with wash-out behavior used in the first colorizing means, (v) arranging means for arranging all spatial units for all time points into a composite of the preselected place with each spatial unit correlated to a color hue/color intensity.
- (a) monitoring means including a first output for monitoring a preselected place in the prostate for collecting data indicative of a parameter that varies with time as a function of at least two variables related to wash-in and wash-out behavior, (b) first processing means including a second output and a first input for receiving the collected data from the first output and processing same, (c) selecting means including a third output for controlling the monitoring means, for setting parameters of data collection and for providing input to the first input, the selecting means including;
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11. Software for use with a computer having a memory, an input device for generating device event signals and a display, the software comprising a computer usable medium having computer readable program code thereon including:
- first program logic for dividing into a grid a space defined by two variables correlated to a preselected parameter of a prostate in a human body in which fluid flows-which is characterized by a change in the prostate with time in space, each variable ranging from a minimum to a maximum;
second program logic responsive to device event signals for determining intensity of each grid location at each of a plurality of time points based on a predetermined intensity function;
third program logic responsive to the second program logic to color all grid locations based on a predetermined color function; and
fourth program logic responsive to the third program logic for developing a composite calibration map of the grid with each grid location correlated to a color hue/color intensity. - View Dependent Claims (12, 13, 14)
- first program logic for dividing into a grid a space defined by two variables correlated to a preselected parameter of a prostate in a human body in which fluid flows-which is characterized by a change in the prostate with time in space, each variable ranging from a minimum to a maximum;
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15. Data processing system for producing a calibration map for use with a monitored prostate in a human body in which a fluid flows and which is characterized by a change in the monitored prostate with time in space and wherein the monitoring occurs at a preselected location comprising:
- (a) computer processing means for processing data;
(b) storage means for storing data on a storage medium;
(c) means for initializing the storage medium;
(d) processing means for dividing the space defined by two variables, each ranging from a minimum to a maximum, into a grid, said variables being con-elated to a preselected parameter of the monitored prostate;
(e) processing means for determining for each grid location a calculated value and intensity function of the parameter at each of a plurality of time points;
(f) processing means for determining the maximum of the intensity function of the grid locations and normalizing all grid locations with reference to the maximum;
(g) processing means for coloring all grid locations one of a plurality of colors based on a color function correlated with monitored prostate behavior;
(h) processing means for arranging all grid locations for all time points into a composite to develop a calibration map of the grid with each grid location correlated to a color hue/color intensity; and
(i) processing means for analyzing the calibration map to determine if the attributes of the calibration map meet a predetermined condition, and, if not, to implement the plurality of time points or variables and iterating until the attributes of the resultant calibration map meet the predetermined condition. - View Dependent Claims (16, 17)
- (a) computer processing means for processing data;
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18. Data processing method for producing a calibration map for use with a monitored prostate in a human body in which a fluid flows and which is characterized by a change in the monitored system with time in space and wherein the monitoring occurs at a preselected location comprising the steps of:
- (a) processing data;
(b) storing data on a storage medium;
(c) initializing the storage medium;
(d) processing by dividing the space defined by two variables, each ranging from a minimum to a maximum, into a grid, said variables being correlated to a preselected parameter of the monitored prostate;
(e) processing for determining for each grid location a calculated value and intensity function of the parameter at each of a plurality of time points;
(f) processing for determining the maximum of the intensity function of the grid locations and normalizing all grid locations with reference to the maximum;
(g) processing for coloring all grid locations one of a plurality of colors based on a color function correlated with monitored prostate behavior;
(h) processing for arranging all grid locations for all time points into a composite to develop a calibration map of the grid with each grid location correlated to a color hue/color intensity; and
(i) processing for analyzing the calibration map to determine if the attributes of the calibration map meet a predetermined condition, and, if not, to implement the plurality of time points or variables and iterating until the attributes of the resultant calibration map meet the predetermined condition.
- (a) processing data;
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19. Method for monitoring a prostate in a human body in which a fluid flows and which is characterized by a change in the prostate with time in space comprising the steps of:
- (a) monitoring a preselected place in the prostate for collecting data indicative of a parameter that varies with time as a function of at least two variables related to wash-in and wash-out behavior;
(b) processing collected data;
(c) controlling the monitoring by setting parameters of data collection and selecting a plurality of time points correlated to a prostate event;
(d) dividing the space defined by the at least two variables, each ranging from a minimum to a maximum, into a grid;
(e) determining for each grid location a calculated value and intensity function of the parameter being monitored for each time point;
(f) determining the maximum intensity of the grid locations and normalizing all grid locations with reference to the maximum;
(g) coloring all grid locations one of a plurality of colors based on a color function correlated with wash-out behavior;
(h) arranging all grid locations for all time points into a composite to develop a calibration map of the grid with each grid location correlated to a color hue/color intensity;
(i) analyzing the calibration map to determine if the attributes of the calibration map meet a preselected condition and, if not, to implement the plurality of time points or a system parameter and iterating until the attributes of the resultant calibration map meet the preselected condition;
(j) inputting the plurality of time points and the maximum of the intensity function as determined in step (f) to the processing of step (b) which further includes the steps of;
(i) spatially dividing the preselected place in the prostate into spatial units;
(ii) determining for each spatial unit a value and intensity function based on the collected data for each time point;
(iii) normalizing the intensity of each spatial unit based on maximum intensity obtained from step (f);
(iv) colorizing all spatial units one of a plurality of colors based on the color function of step (g);
(v) arranging all spatial units for all time points into a composite of the preselected place with each spatial unit correlated to a color hue/color intensity. - View Dependent Claims (20, 21, 22, 23, 24)
- (a) monitoring a preselected place in the prostate for collecting data indicative of a parameter that varies with time as a function of at least two variables related to wash-in and wash-out behavior;
- 25. A calibration map for use in monitoring a prostate of a human body in which fluid flows and which is characterized by a change in a prostate parameter with time in space as a function of two variables related to prostate wash-in and system wash-out behavior at two time intervals after a prostate event, which map depicts in two or three dimensions an image of the two variables ranging from a minimum to a maximum wherein the discrete elements of the image have a color hue of one of a plurality of colors indicative of prostate wash-out behavior and a color intensity indicative of prostate wash-in behavior.
- 31. An image depicting in two or three dimensions a location in a prostate in a human body in which fluid flows and which is characterized at said location by a change in a prostate parameter as a function of two variables related to prostate wash-in behavior at a first time interval and prostate wash-out behavior at a second time interval after a prostate event, the discrete elements of the image having a color hue of one of a plurality of colors indicative of prostate wash-out behavior and a color intensity indicative of prostate wash-in behavior.
Specification