Liquid handling device with surface features at a seal

• US 7,246,551 B2
• Filed: 07/09/2004
• Issued: 07/24/2007
• Est. Priority Date: 07/09/2004
• Status: Active Grant

• Current Assignee: Protedyne Corporation (Laboratory Corporation Of America Holdings)
• Original Assignee: Protedyne Corporation (Laboratory Corporation Of America Holdings)
• Inventors: Massaro, Peter, Paschetto, Michael
• Primary Examiner(s): LESLIE, MICHAEL S
• Application Number:
  US10/887,706
• Publication Number:
  US 20060008370A1
• Time in Patent Office: 1,110 Days
• Field of Search: 921/53, 921/58, 921/59, 604/230
• US Class Current: 92/158
• CPC Class Codes: A61M 2005/3131 specially adapted for improving sealing or sliding
• CPC Class Codes: A61M 5/31513 Piston constructions to improve sealing or sliding
• CPC Class Codes: B01L 2200/0689 Sealing
• CPC Class Codes: B01L 3/0217 of the plunger pump type medical syringes A61M
• CPC Class Codes: G01N 2035/103 using disposable tips
• CPC Class Codes: G01N 2035/1039 Micropipettes, e.g. microcapillary tubes
• CPC Class Codes: G01N 35/1065 Multiple transfer devices

Abstract

A sample handling tool includes a body having at least one plunger associated with a channel and arranged for axial movement within the channel. A seal is provided in the channel and sealingly engaged with a contact surface. The contact surface may include a surface feature, such that when contact surface moves, the seal and surface feature come into at least partial contact with one another. The seal may include an elastomeric member, such as an O-ring or X-ring, and the contact surface may be formed from any suitable material, including ceramic. The surface feature may take on a variety of forms including any suitable texture, surface porosity or include one or more grooves, holes, recesses, indentations, bumps, protrusions, etc., or a combination thereof.

Claims

1. A liquid handling device comprising:

a body with at least one channel, the channel having an end for receiving and expelling fluid;

a needle in fluid communication with the end of the channel to aspirate and/or dispense a fluid sample on a work area;

a plunger constructed and arranged for axial movement within the channel;

a contact surface including a surface feature that forms a non-smooth surface; and

a seal provided in the channel that sealingly engages a portion of the plunger with a portion of the body, the seal including a seal member mounted on the body, and at least a portion of the contact surface including the surface feature being located at the seal;

wherein the plunger includes the contact surface for sealing engagement with the seal member, and movement of the plunger in the channel causes movement of the body relative to the plunger at the seal and causes fluid flow at the end of the channel that is effective to aspirate and/or dispense the fluid sample on the work area via the needle.

2. The device of claim 1, wherein lubricant is at least partially engaged in the surface feature on the contact surface to assist in providing the sealing engagement at the seal.

3. The device of claim 1, wherein at least a portion of the contact surface moves with the plunger.

4. The device of claim 3, wherein at least a portion of the surface feature engages the seal within a range of motion of the plunger.

5. The device of claim 1, wherein the surface feature includes at least one recess.

6. The device of claim 5 wherein the recess includes at least one groove.

7. The device of claim 1, wherein the surface feature includes at least one protrusion.

8. The device of claim 1, wherein the surface feature includes a porous surface.

9. The device of claim 1, wherein the contact surface is formed from ceramic.

10. The device of claim 1, further comprising:

the channel being one of a plurality of channels, each of the channels having an open end for receiving and expelling fluid;

the plunger being one of a plurality of plungers, each of the plungers associated with a corresponding channel;

the contact surface being one of a plurality of contact surfaces, each contact surface including a surface feature; and

the seal being one of a plurality of seals, each of the seals provided in a corresponding channel and sealingly engaging a portion of a corresponding plunger with a portion of the body.

11. A liquid handling device comprising:

a body with at least one channel, the channel having an end for receiving and expelling fluid;

a needle in fluid communication with the end of the channel to aspirate and/or dispense a fluid sample on a work area;

a plunger constructed and arranged for axial movement within the channel;

a contact surface including a surface feature that forms a non-smooth surface; and

a seal provided in the channel that sealingly engages a portion of the plunger with a portion of the body, the seal including a seal member mounted on the plunger, and at least a portion of the contact surface including the surface feature being located at the seal;

wherein the channel includes the contact surface for sealing engagement with the seal member, and movement of the plunger in the channel causes movement of the body relative to the plunger at the seal and causes fluid flow at the end of the channel that is effective to aspirate and/or dispense the fluid sample on the work area via the needle.

12. A liquid handling device comprising:

a body with at least one channel, the channel having an end for receiving and expelling fluid;

a needle in fluid communication with the end of the channel to aspirate and/or dispense a fluid sample on a work area;

a plunger constructed and arranged for axial movement within the channel;

a contact surface including a surface feature that forms a non-smooth surface; and

a seal provided in the channel that sealingly engages a portion of the plunger with a portion of the body, the seal including a seal member with at least two contact points constructed and arranged for sealing engagement at displaced locations on the contact surface, and at least a portion of the contact surface including the surface feature being located at the seal;

wherein movement of the plunger in the channel causes movement of the body relative to the plunger at the seal and causes fluid flow at the end of the channel that is effective to aspirate and/or dispense the fluid sample on the work area via the needle.

13. The device of claim 12, wherein the seal member includes an X-ring.

14. A liquid handling apparatus comprising:

a body with at least one channel;

a needle in communication with the channel;

a piston constructed and arranged for axial movement within the channel;

an engagement surface including a surface means for retaining lubricant; and

a seal provided in the channel between the piston and the body, the seal including a seal member mounted on the body, and sealingly engaging the piston and the channel at a portion of the engagement surface, wherein the piston includes the engagement surface for sealing contact with the seal member, and movement of the piston in the channel causes fluid flow in the needle.

15. The apparatus of claim 14, wherein lubricant is at least partially engaged in the surface means on the engagement surface to assist in providing the sealing contact of the engagement surface at the seal.

16. The apparatus of claim 14, wherein the engagement surface moves with the piston.

17. The apparatus of claim 16, wherein at least a portion of the surface means contacts the seal within a range of motion of the piston.

18. The apparatus of claim 14, wherein the surface means includes at least one recess.

19. The apparatus of claim 18, wherein the recess includes at least one groove.

20. The apparatus of claim 14, wherein the surface means includes at least one protrusion.

21. The apparatus of claim 14, wherein the surface means includes a porous surface.

22. The apparatus of claim 14, wherein the engagement surface is formed from ceramic.

23. The apparatus of claim 14, wherein:

the seal member includes at least two contact points constructed and arranged for sealing engagement with the contact surface.

24. The apparatus of claim 23, wherein the seal member includes an X-ring.

25. The apparatus of claim 14, further comprising:

the channel being one of a plurality of channels;

the needle being one of a plurality of needles, each of the needles in communication with a corresponding channel;

the piston being one of a plurality of pistons, each of the pistons associated with a corresponding channel;

the engagement surface being one of a plurality of engagement surfaces, each engagement surface including a surface means; and

the seal being one of a plurality of seals, each of the seals provided in a corresponding channel and sealingly engaging a portion of a corresponding piston with a portion of the body.

26. A liquid handling apparatus, comprising:

a body with at least one channel;

a needle in communication with the channel, the needle having an open end for receiving and expelling fluid;

a plunger constructed and arranged for axial movement within the channel, the plunger having a contact surface;

at least one groove provided on the contact surface; and

an X-ring mounted to the channel and sealingly engaged with the contact surface of the plunger,

wherein movement of the plunger in the channel causes fluid flow at the open end of the needle.

27. The apparatus of claim 26, wherein the plunger is formed of a ceramic.

28. The apparatus of claim 26, wherein lubricant on the plunger is at least partially engaged in the at least one groove to assist in providing the sealing engagement between the contact surface and the X-ring.

29. The apparatus of claim 26, wherein the contact surface moves relative to the X-ring within a range of motion of the plunger.

30. The apparatus of claim 26, wherein at least a portion of the groove contacts the X-ring during the range of motion of the plunger.

31. The apparatus of claim 26, further comprising:

the channel being one of a plurality of channels;

the needle being one of a plurality of needles, each of the needles in communication with a corresponding channel;

the plunger being one of a plurality of plungers, each of the plungers associated with a corresponding channel;

the contact surface being one of a plurality of contact surfaces, each contact surface provided on a plunger and including at least one groove; and

the X-ring being one of a plurality of X-rings, each of the X-rings mounted to a corresponding channel and sealingly engaged with a corresponding contact surface.