Micro-reactor for reactions between gases and liquids

• US 7,247,276 B2
• Filed: 07/25/2001
• Issued: 07/24/2007
• Est. Priority Date: 07/27/2000
• Status: Expired due to Fees

• Current Assignee: YMC Co., Ltd. (YMC Investment KK)
• Original Assignee: Cellular Process Chemistry, Inc.
• Inventors: Golbig, Klaus, Dittmann, Bernd, Schuppich, Harald
• Primary Examiner(s): Bhat; N.
• Application Number:
  US10/343,275
• Publication Number:
  US 20040156762A1
• Time in Patent Office: 2,190 Days
• Field of Search: 422/191, 422/220, 422/224, 422/129, 366/340, 366/336, 366/341
• US Class Current: 422/129
• CPC Class Codes: B01J 19/0093 Microreactors, e.g. miniaturised or microfabricated reactors laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027
• CPC Class Codes: B01J 2219/00783 Laminate assemblies, i.e. the reactor comprising a stack of plates
• CPC Class Codes: B01J 2219/00835 Comprising catalytically active material
• CPC Class Codes: B01J 2219/00873 Heat exchange
• CPC Class Codes: B01J 2219/00952 Sensing operations
• CPC Class Codes: B01J 2219/00959 Flow
• CPC Class Codes: B01J 2219/00961 Temperature
• CPC Class Codes: B01J 2219/00966 pH
• CPC Class Codes: B81B 1/00 Devices without movable or flexible elements, e.g. microcapillary devices
• CPC Class Codes: F28D 3/00 Heat-exchange apparatus having stationary conduit assemblies for one heat-exchange medium only, the media being in contact with different sides of the conduit wall, in which the other heat-exchange medium flows in a continuous film, or trickles freely, over the conduits F28D5/00 takes precedence
• CPC Class Codes: F28F 2260/02 having microchannels
• CPC Class Codes: F28F 3/048 in the form of ribs integral with the element or local variations in thickness of the element, e.g. grooves, microchannels

Abstract

Described herein is a microreactor for carrying out chemical reactions between a reaction partner in liquid form and a reaction partner in gaseous form, if necessary in the presence of a solid catalyst, whereby the chemical process guidance takes place in spaces that are formed by two or more essentially coplanar plates or layers, with at least one of these plates or layers being a fluid guidance plate (1) that is structured and/or arranged in such a way that the fluid reaction partner flows in at least one essentially uninterrupted capillary thread along the surface of this plate or layer only due to the influence of gravity and/or capillary forces and thereby comes into contact and reacts with the gaseous reaction partner.

Claims

1. A microreactor for carrying out chemical reactions between a liquid reactant and a gaseous reactant, comprising:

(a) a fluid guidance plate comprising a plurality of longitudinally extending elongate open channels, such channels being configured so that when the liquid reactant is introduced into the plurality of open channels, dimensions of said plurality of open channels ensure that a capillary action establishes a capillary thread of the liquid reactant that is retained in said plurality of longitudinally extending elongate open channels, even when the fluid guidance plate is oriented in a vertical position, the liquid reactant being conveyed through the plurality of longitudinally extending elongate open channels by the capillary action when the fluid guidance plate is in a horizontal position, and by the capillary action and a gravitational force when the fluid guidance plate is in a non-horizontal position; and

(b) a reaction volume disposed adjacent to the fluid guidance plate, so that the reaction volume is in fluid communication with the plurality of longitudinally extending elongate open channels, so that when the gaseous reactant is introduced into the reaction volume, the gaseous reactant is in fluid communication with the liquid reactant that is retained in and which is being conveyed in said plurality of longitudinally extending elongate open channels, a product being produced by a reaction between the gaseous reactant and the liquid reactant, said product being conveyed through the plurality of longitudinally extending elongate open channels by the capillary action when the fluid guidance plate is in a horizontal position, and by the capillary action and a gravitational force when the fluid guidance plate is in a non-horizontal position.

2. The microreactor according to claim 1, wherein the fluid guidance plate is disposed in a non-vertical orientation, thereby reducing a magnitude of a flow rate of the liquid reactant attributable to the gravitational force as compared to the flow rate of the liquid reactant when the fluid guidance plate is disposed in the vertical orientation.

3. The microreactor according to claim 1, wherein the fluid guidance plate comprises a rear wall, the rear wall defining a bottom of the plurality of open channels, and the rear wall of the fluid guidance plate is in contact with a heat exchange volume, thereby enabling a temperature of a material in the plurality of open channels to be moderated.

4. The microreactor according to claim 3, wherein:

(a) the fluid guidance plate farther comprises a plurality of longitudinally extending panels coupled to the rear wall, the panels defining sidewalls of the plurality of open channels, the longitudinally extending panels having a width ranging from about 5 μ

m to about 250 μ

m;

(b) the rear wall has a thickness ranging from about 120 μ

m to about 4000 μ

m, and

(c) the plurality of longitudinally extending open channels have a width ranging from about 20 μ

m to about 2000 μ

m, and a depth ranging from about 20 μ

m to about 500 μ

m.

5. The microreactor according to claim 1, wherein the fluid guidance plate is sandwiched between a top plate and a bottom plate, the top plate defining the reaction volume and the bottom plate defining a heat transfer volume.

6. The microreactor of claim 5, wherein a number of reaction volumes in the microreactor can be increased by inserting a desired number of intermediate plates and additional fluid guidance plates between the bottom plate and the top plate in an alternating fashion, where an equal number of intermediate and fluid guidance plates are employed, each intermediate plate added defining an additional reaction volume.

7. The microreactor according to claim 1, further comprising:

(a) one or more separate and/or common inlet tubes for the liquid reactant;

(b) one or more inlet and discharge tubes for the gaseous reactant;

(c) one or more separate and/or common discharge tubes for the produced reaction mixture;

(d) one or more inlet and discharge tubes for a heat exchange medium; and

(e) sensors for controlling the reaction conditions.

8. The microreactor according to claim 1, further comprising means for uniformly distributing the liquid reactant to the open channels.

9. The microreactor according to claim 1, further comprising a bottleneck disposed between a gaseous reactant inlet and the reaction volume.

10. The microreactor according to claim 9, wherein the reaction volume is equipped with ramps for improving a mass transfer of the reactants.

11. The microreactor according to claim 1, wherein a rear wall of the fluid guidance plate is thermally conditioned by a heat transfer medium flowing through channels ranging from about 0.5 mm to about 2 mm in width.

12. The microreactor according to claim 1, wherein the fluid guidance plate is made from at least one element selected from the group consisting essentially of graphite, ceramic, plastic, and metal.

13. The microreactor according to claim 1, wherein the fluid guidance plate comprises a catalyst.

14. The microreactor of claim 1, wherein the fluid guidance plate comprises:

(a) a first element, the first element comprising an unstructured plate having a first end, a second end, a length, a width, and a thickness, the first element defining a rear wall of the fluid guidance plate;

(b) a second element coupled to the first element, the second element comprising a structured plate having a first end, a second end, a length corresponding to the length of the first element, a width corresponding to the width of the first element, and a thickness, the structured plate including a plurality of elongate parallel openings extending from the first end to the second end, each opening thus defining one of the plurality of longitudinally extending open channels, solid portions of the second element disposed between each opening defining the longitudinally extending panels of the fluid guidance plate.

15. The microreactor of claim 14, wherein:

(a) the thickness of the first element ranges from about 20 μ

m to about 4000 μ

m;

(b) the thickness of the second element ranges from about 20 μ

m to about 500 μ

m;

(c) each opening in the second element has a width ranging from about 20 μ

m to about 2000 μ

m; and

(d) a distance between adjacent openings in the second element ranges from about 5 μ

m to about 250 μ

m.

16. A microreactor for carrying out chemical reactions between a liquid reactant and a gaseous reactant, comprising:

(a) a fluid inlet for the liquid reactant;

(b) a fluid inlet for the gaseous reactant;

(c) a fluid guidance plate having a first end and a second end, a rear wall and a plurality of panels extending longitudinally between the first end and the second end, thereby defining a plurality of longitudinally extending elongate open channels, the rear wall serving as a floor for each channel of the plurality of longitudinally extending elongate open channels, and adjacent panels serving as sidewalls for each longitudinally extending elongate open channel, the first end being coupled in fluid communication with the fluid inlet for the liquid reactant, so that when the liquid reactant is introduced into the plurality of longitudinally extending elongate open channels, the liquid reactant being conveyed through said plurality of longitudinally extending elongate open channels toward the second end by a capillary action when the fluid guidance plate is disposed in a horizontal position, and by the capillary action and a gravitational force when the fluid guidance plate is disposed in a non-horizontal position, thereby establishing an uninterrupted capillary thread of liquid reactant in each longitudinally extending elongate open channel; and

(d) a reaction volume disposed adjacent to the fluid guidance plate and between the first end and the second end, the reaction volume being coupled in fluid communication with the fluid inlet for the gaseous reactant, the reaction volume being in fluid communication with the plurality of longitudinally extending open channels, so that the gaseous reactant in the reaction volume reacts with the liquid reactant being conveyed in said plurality of longitudinally extending open channels to generate a product in the plurality of longitudinally extending elongate open channels; and

(e) a product outlet coupled in fluid communication with the second end of the fluid guidance plate, to collect the product from said plurality of longitudinally extending elongate open channels.

17. A microreactor for carrying out chemical reactions between a liquid reactant and a gaseous reactant, comprising:

(a) a fluid guidance plate having;

(i) a first end and a second end, a rear wall, and a plurality of panels extending between the first end and the second end, said plurality of panels defining a plurality of elongate open channels, the rear wall serving as a floor for each channel of the plurality of longitudinally extending elongate open channels, and adjacent panels serving as sidewalls for each channel, the liquid reactant being conveyed through said plurality of elongate open channels toward the second end by a capillary action when the fluid guidance plate is disposed in a horizontal position, and by the capillary action and a gravitational force when the fluid guidance plate is disposed in a non-horizontal position; and

(ii) means for establishing an uninterrupted capillary thread of liquid reactant in said plurality of the elongate open channels, such that the capillary thread of liquid reactant is retained within said plurality of elongate open channels, even when the fluid guidance plate and said plurality of elongate open channels are oriented in a vertical position; and

(b) a reaction volume disposed adjacent to the fluid guidance plate and between the first end and the second end, the reaction volume being coupled in fluid communication with the plurality of elongate open channels, so that the gaseous reactant in the reaction volume reacts with the liquid reactant being conveyed in said plurality of elongate open channels to generate a product in said plurality of elongate open channels.

18. A method for using a fluid guidance plate for reacting a liquid reactant and a gaseous reactant to form a chemical product, comprising the steps of:

(a) introducing the liquid reactant into the fluid guidance plate, the fluid guidance plate comprising a plurality of elongate open channels, thereby establishing a plurality of uninterrupted capillary threads of the liquid reactant in the plurality of elongate open channels, a capillary action retaining the liquid reactant in the plurality of elongate open channels even when the fluid guidance plate is in a non-horizontal position, the liquid reactant being conveyed through the plurality of elongate open channels by the capillary action when the fluid guidance plate is in a horizontal position, and by the capillary action and a gravitational force when the fluid guidance plate is in the non-horizontal position;

(b) introducing the gaseous reactant into a reaction volume, the reaction volume being in fluid communication with the plurality of elongate open channels, such that the gaseous reactant is placed in fluid communication with the liquid reactant while the liquid reactant is retained in the plurality of elongate open channels, a reaction between the gaseous reactant and the liquid reactant generating the chemical product, the chemical product being conveyed away from the reaction volume in the plurality of elongate open channels by the capillary action when the fluid guidance plate is in the horizontal position, and by the capillary action and the gravitation force when the fluid guidance plate is in the non-horizontal position.

19. The method of claim 18, wherein the gaseous reactant is selected from the group consisting essentially of hydrogen, fluorine, chlorine, oxygen, and an alkylene oxide.

20. A method for reacting a liquid reactant and a gaseous reactant to form a chemical product, comprising the steps of:

(a) establishing a plurality of uninterrupted capillary threads of the liquid reactant, a flow rate of the liquid reactant in the capillary threads being provided a capillary action when the plurality of uninterrupted capillary threads are disposed in a horizontal configuration, and by the capillary action and a gravitational force when the plurality of uninterrupted capillary threads are disposed in a non-horizontal configuration, the capillary action inhibiting the liquid reactant from diverging from each capillary thread when the plurality of uninterrupted capillary threads are disposed in the non-horizontal configuration; and

(b) placing a gaseous reactant in fluid communication with the plurality of capillary threads, such that the gaseous reactant is placed in fluid communication with the liquid reactant, a reaction between the gaseous reactant and the liquid reactant generating the chemical product in the plurality of capillary threads.

21. The method of claim 20, further comprising the step of manipulating a flow rate of the liquid reactant in the plurality of capillary threads by moving a fluid guidance plate supporting the plurality of capillary threads to a desired orientation between a vertical position and a horizontal position, where a minimum flow rate is achieved when the fluid guidance plate is in the horizontal position, the flow rate in the horizontal position being provided by the capillary action alone, and wherein a maximum flow rate is achieved when the fluid guidance plate is in the vertical position, the flow rate in the vertical position being provided by both the capillary action and the gravitational force, the flow rate continuously decreasing as the orientation of the fluid guidance plate is moved between the vertical position and the horizontal position.