Treatment of brain damage
First Claim
1. A method for treating brain damage in a mammal, comprising administering pluripotent neuroepithelial cells into the mammal'"'"'s damaged brain, wherein administration is into the brain hemisphere contra-lateral to that containing the site of damage, wherein said pluripotent neuroepithelial cells have been genetically modified to be conditionally immortal, wherein said pluripotent neuroepithelial cells are immortal prior to administration and differentiate after administration, and wherein administration of said pluripotent neuroepithelial cells improves said brain damage of the mammal.
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Abstract
The present invention relates to the treatment of brain damage by cellular transplantation. According to one aspect of the invention, a method for treating a motor, sensory and/or cognitive deficit comprises administering a composition comprising pluripotent cells into the damaged brain in a region contra-lateral to that containing the site of damage. The cells are preferably conditionally immortal.
15 Citations
11 Claims
- 1. A method for treating brain damage in a mammal, comprising administering pluripotent neuroepithelial cells into the mammal'"'"'s damaged brain, wherein administration is into the brain hemisphere contra-lateral to that containing the site of damage, wherein said pluripotent neuroepithelial cells have been genetically modified to be conditionally immortal, wherein said pluripotent neuroepithelial cells are immortal prior to administration and differentiate after administration, and wherein administration of said pluripotent neuroepithelial cells improves said brain damage of the mammal.
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