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Reduction of the hook effect in membrane-based assay devices

  • US 7,247,500 B2
  • Filed: 12/19/2002
  • Issued: 07/24/2007
  • Est. Priority Date: 12/19/2002
  • Status: Expired due to Fees
First Claim
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1. A flow-through assay device for detecting the presence or quantity of an analyte residing in a test sample, said flow-through assay device comprising a porous membrane, said porous membrane being in communication with conjugated detection probes capable of generating a detection signal, said porous membrane defining:

  • a chromatographic zone within which a plurality of microporous particles are immobilized; and

    a detection zone located downstream from said chromatographic zone, wherein a capture reagent is immobilized within said detection zone that is configured to bind to said conjugated detection probes, wherein said conjugated detection probes are capable of generating a detection signal while within said detection zone, wherein the amount of the analyte within the test sample is determined from said detection signal.

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