Apparatus and process for conditioning mammalian blood

• US 7,250,137 B2
• Filed: 12/06/2005
• Issued: 07/31/2007
• Est. Priority Date: 09/16/1999
• Status: Expired due to Fees

• Current Assignee: Vasogen Ireland Ltd.
• Original Assignee: Vasogen Ireland Ltd.
• Inventors: Newman, Duncan, Moore, Paul, Muirhead, Allen, Treadwell, Simon, Voakes, Murray, Mongomery, Sonya, Worona, Taras, Chong, Carlton, Porter, Thomas, Liao, Liung Sen, Dayman, Jeff
• Primary Examiner(s): Zalukaeva; Tatyana
• Assistant Examiner(s): Deak; Leslie R.
• Application Number:
  US11/294,384
• Publication Number:
  US 20060073069A1
• Time in Patent Office: 602 Days
• Field of Search: 604/4.01, 604/5.04, 604/6.08, 604/6.14, 604/6.15, 604 23- 25, 604/403, 604/416, 604/405, 604/406, 206363-366, 222/129, 222/132, 222/145.5, 321/31, 321/31.1, 422 44- 48, 137/583, 137/590, 137/602, 137/896
• US Class Current: 422/44
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: A61M 1/0281 Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
• CPC Class Codes: A61M 1/3623 Means for actively controlling temperature of blood
• CPC Class Codes: A61M 1/3626 Gas bubble detectors
• CPC Class Codes: A61M 1/3681 by irradiation
• CPC Class Codes: A61M 1/3687 Chemical treatment A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/369 Temperature treatment
• CPC Class Codes: A61M 2202/0216 Ozone
• CPC Class Codes: A61M 2205/052 infrared
• CPC Class Codes: A61M 2205/053 ultraviolet
• CPC Class Codes: A61M 2205/123 with incorporated reservoirs
• CPC Class Codes: A61M 2205/368 by electromagnetic radiation, e.g. IR waves
• CPC Class Codes: A61M 2205/75 with filters

Abstract

An apparatus for conditioning mammalian blood for subsequent use in a medical procedure includes a cabinet having a secure environment and a door providing the only access to the environment. An input system transports a blood charge from a source to the cabinet and a flask is removably contained in the secure environment and coupled to the charge input system to receive the charge. Stressors are coupled to the cabinet and positioned for operation to create a conditioned charge in the flask. An output system is coupled to the flask and includes a receiver for the conditioned charge. The apparatus includes an automated control system operable upon closing the door to lock the door and to then condition the charge, and to then cause the charge to move from the flask to the receiver.

Claims

1. A flask assembly for use in apparatus having a cabinet made to receive the flask assembly for conditioning mammalian blood, the flask assembly including:

a flask in the form of an envelope defining a substantially enclosed volume and including a top and a bottom, the top having an access opening and an outlet;

a connector assembly coupled to said top of the flask;

a probe extending from the connector assembly, through the access opening and having a top end and a leading end, the probe being sealed in the access opening and defining an input lumen for transporting a charge to the bottom of the flask, an output lumen for transporting conditioned charge from the bottom of the flask out of the flask, and a gas lumen for feeding gas into the flask to condition the charge when a charge is in the flask;

the connector assembly including outlet tubing coupled to said outlet to lead spent gas out of the flask, and inlet tubing coupled to the gas lumen;

a pair of gas connectors coupled to a platform and connected to the respective gas inlet tubing and to the gas outlet tubing to make gas connections when the flask assembly is mounted in the apparatus, whereby as the flask is engaged in the cabinet the gas connectors engage a gas supply system for conditioning said charge in the flask before removing the conditioned charge;

the probe including a further lumen containing a temperature probe for monitoring the temperature of the charge, the temperature probe being located near the leading end of the probe; and

said further lumen ends at a side opening in the probe, and the temperature probe being positioned in the opening for better thermal conductivity from the charge to the temperature sensor.

2. A flask assembly as claimed in claim 1 in which said enclosed volume is in the order of about 70 times the volume of the charge to be entered into the flask.

3. A flask assembly as claimed in claim 1 in which the flask is of low density polyethylene.

4. A flask assembly as claimed in claim 1 in which the platform includes an overhanging portion extending outwardly from said top, and in which the gas connectors are mounted on the overhanging portion and in which the gas supply system includes fittings adapted to be mounted on the cabinet for engagement with the gas connectors when the flask is engaged in the cabinet.

5. A flask assembly as claimed in claim 1 and further including a cover attached to the platform to contain the platform and present a cleaner appearance.

6. A flask assembly as claimed in claim 5 in which the cover is attached to the flask.

7. A flask assembly as claimed in claim 6 in which the cover is a snap fit on the flask, and in which the cover and flask are arranged so that the cover fits on the flask with the outlet tubing aligned with the outlet in said top.

8. A flask assembly as claimed in claim 1 and further including in-line filters in the gas inlet tubing and in the gas outlet tubing, the in-line filters being mounted on the platform.

9. A flask assembly as claimed in claim 1 in which the flask defines an upper cylindrical portion and a smaller lower cup at the bottom of the flask, the cup being proportioned to receive the charge, and in which the leading end of the probe is contained close to said bottom.

10. A flask assembly as claimed in claim 1 and further including a an extension engaged in the leading end of said further lumen and projecting downwardly, and in which the flask includes a socket at the leading end shaped to receive the extension to locate the leading end of the probe relative to the flask.

11. A flask assembly as claimed in claim 1 in which:

the flask defines an upper cylindrical portion and a smaller lower cup at the bottom of the flask, the cup being proportioned to receive the charge, and in which the leading end of the probe is contained close to said bottom; and

in which the flask assembly further includes an extension engaged in the leading end of said further lumen and projecting downwardly, and in which the flask includes a socket at the leading end shaped to receive the extension to locate the leading end of the probe relative to the cup.

12. A flask assembly as claimed in claim 1 in which the platform includes an overhanging portion extending outwardly from said top, and electrical contacts mounted on the overhanging portion for engagement automatically with suitable fittings adapted to be mounted on the cabinet when the flask is engaged in the cabinet.

13. A flask assembly as claimed in claim 1 and further comprising input and output syringes releasably mounted on the connector assembly, the input syringe being connected to the input tubing and the outlet syringe being connected to the output tubing.

14. A flask assembly for use in apparatus having a cabinet made to receive the flask assembly for conditioning mammalian blood, the flask assembly including:

a flask in the form of an envelope defining a substantially enclosed volume and including a top and a bottom, the top having an access opening and an outlet;

a connector assembly coupled to said top of the flask;

a probe extending from the connector assembly, through the access opening and having a top end and a leading end, the probe being sealed in the access opening and defining an input lumen for transporting the charge to the bottom of the flask, an output lumen for transporting conditioned charge from the bottom of the flask out of the flask, and a gas lumen for feeding gas into the flask to condition the charge when a charge is in the flask;

the connector assembly including outlet tubing coupled to said outlet to lead spent gas out of the flask, and inlet tubing coupled to the gas lumen;

a pair of gas connectors coupled to a platform and connected to the respective gas inlet tubing and to the gas outlet tubing to make gas connections when the flask assembly is mounted in the apparatus, whereby as the flask is engaged in the cabinet the gas connectors engage a gas supply system for conditioning said charge in the flask before removing the conditioned charge; and

the probe including a further lumen containing a temperature probe for monitoring the temperature of the charge, the temperature probe being located near the leading end of the probe, and the platform including an overhanging portion extending outwardly from said top, and electrical contacts mounted on the overhanging portion for engagement automatically with suitable fittings adapted to be mounted on the cabinet when the flask is engaged in the cabinet.

15. A flask assembly as claimed in claim 14 in which:

the flask defines an upper cylindrical portion and a smaller lower cup at the bottom of the flask, the cup being proportioned to receive the charge, and in which the leading end of the probe is contained close to said bottom; and

in which the flask assembly further includes an extension engaged in the leading end of said further lumen and projecting downwardly, and in which the flask includes a socket at the leading end shaped to receive the extension to locate the leading end of the probe relative to the cup.

16. A flask assembly as claimed in claim 14 in which said further lumen ends at a side opening in the probe, and in which the temperature probe is positioned in the opening for better thermal conductivity from the charge to the temperature sensor.

17. A flask assembly for use in apparatus having a cabinet made to receive the flask assembly for conditioning mammalian blood, the flask assembly including:

a flask in the form of an envelope defining a substantially enclosed volume and including a top and a bottom, the top having an access opening and an outlet;

a connector assembly coupled to said top of the flask;

a probe extending from the connector assembly, through the access opening and having a top end and a leading end, the probe being sealed in the access opening and defining an input lumen for transporting the charge to the bottom of the flask, an output lumen for transporting conditioned charge from the bottom of the flask out of the flask, and a gas lumen for feeding gas into the flask to condition the charge when a charge is in the flask;

the connector assembly including outlet tubing coupled to said outlet to lead spent gas out of the flask, and inlet tubing coupled to the gas lumen;

a pair of gas connectors coupled to a platform and connected to the respective gas inlet tubing and to the gas outlet tubing to make gas connections when the flask assembly is mounted in the apparatus, whereby as the flask is engaged in the cabinet the gas connectors engage a gas supply system for conditioning said charge in the flask before removing the conditioned charge; and

input and output syringes releasably mounted on the connector assembly, the input syringe being connected to the input tubing and the outlet syringe being connected to the output tubing.

18. A flask assembly as claimed in claim 17 in which the probe includes a further lumen containing a temperature probe for monitoring the temperature of the charge, the temperature probe being located near the leading end of the probe.

19. A flask assembly as claimed in claim 18 in which said further lumen ends at a side opening in the probe, and in which the temperature probe is positioned in the opening for better thermal conductivity from the charge to the temperature sensor.