Chemistry system for a clinical analyzer

• US 7,250,303 B2
• Filed: 06/28/2002
• Issued: 07/31/2007
• Est. Priority Date: 07/20/2001
• Status: Active Grant

• Current Assignee: Ortho-Clinical Diagnostics Incorporated (The Carlyle Group LP (Corporate Private Equity))
• Original Assignee: Ortho-Clinical Diagnostics Incorporated (The Carlyle Group LP (Corporate Private Equity))
• Inventors: Shaw, James David, Jakubowicz, Raymond Francis, Tomasso, David Angelo, LaCourt, Michael W.
• Primary Examiner(s): Warden; Jill
• Assistant Examiner(s): LEVKOVICH, NATALIA A
• Application Number:
  US10/185,613
• Publication Number:
  US 20030022380A1
• Time in Patent Office: 1,859 Days
• Field of Search: 422/100, 422/130, 436/54
• US Class Current: 436/54
• CPC Class Codes: B01L 3/0275 Interchangeable or disposable dispensing tips
• CPC Class Codes: G01N 2035/103 using disposable tips
• CPC Class Codes: G01N 35/10 Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices G01N35/0099 takes precedence
• CPC Class Codes: G01N 35/1002 Reagent dispensers
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/114998 with treatment or replacement of aspirator element [e.g., cleaning, etc.]
• CPC Class Codes: Y10T 436/119163 with aspirator of claimed structure
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

A clinical analyzer for determining the presence or amount of an analyte in a sample includes at least one reagent supply and at least one reaction containment device for containing a volume of sample and a volume of said at least one reagent from said at least one reagent supply. A wash-free delivery system introduces reagent into at least one reaction containment device without requiring washing of delivery components.

Claims

1. A wash-free reagent delivery system for introducing a volume of at least one reagent into a reaction containment device in a clinical analyzer, said system including:

a patient sample supply;

at least one reagent supply;

at least one metering system including a metering head movable between said at least one reagent supply and said reaction containment device;

a first plurality of disposable fluid dispensing tips used to aspirate a volume of reagent from said at least one reagent supply for single-use dispensing into said reaction containment; and

a second plurality of disposable fluid dispensing tips, each of said second plurality of disposable fluid dispensing tips having a sealed dispense end wherein each of the dispense ends of said second plurality of disposable tips are sealed after a quantity of patient sample is initially aspirated therein using said at least one metering system, thereby forming a container.

6. A system as recited in claim 1, wherein each of said first plurality of disposable tips are sized to fit within the reaction containment device and to dispense said volume of reagent directly into liquid already contained in said reaction containment device.

7. A system as recited in claim 6, wherein said first plurality of tips are disposed in said patient sample supply.

8. A system as recited in claim 7, wherein said sample supply includes a pair of rotors, each of said rotors being supported for rotational movement and including a plurality of stations wherein said first plurality of tips are disposed in stations in a first of said rotors and said second plurality of sealed tips are disposed in the other of said rotors.

9. A system as recited in claim 6, including a third plurality of disposable tips used to aspirate patient sample from a said sealed disposable tip in said sample supply using said metering system and for dispensing patient sample into said reaction containment device.

10. A system as recited in claim 9, wherein said third plurality of disposable tips are disposed in a supply between said patient sample supply and said at least one reagent supply.

2. A clinical analyzer comprising:

at least one reagent supply;

a patient sample supply;

metering system including a metering head that is movable along a metering rail;

at least one reaction vessel containing a volume of patient sample dispensed from said patient sample supply and a volume of at least one reagent dispensed from said at least one reagent supply; and

a first plurality of disposable metering tips, said first plurality of disposable metering tips each being used by said metering system to aspirate said volume of at least one reagent from said at least one reagent supply and to dispense said volume into the confines of said at least one reaction vessel wherein each said tip of said first plurality of disposable tips includes a dispense end that is placed by said metering system into said at least one reaction vessel and directly into contact with said volume of patient sample contained therein, said patient sample supply further comprising a second plurality of disposable tips, each of said second plurality of disposable tips containing a quantity of patient sample initially aspirated therein using said metering system, each of said second plurality of disposable tips further including a sealed dispense end, thereby forming a container, said sealed dispense end being formed after initial aspiation of patient sample.

3. An analyzer as recited in claim 2, wherein said reaction vessel is a reaction cuvette.

4. An analyzer as recited in claim 3, wherein said reaction vessel is disposable.

11. An analyzer as recited in claim 2, including a third plurality of disposable tips, each of said third plurality of tips being used to aspirate said volume of patient sample from one of said second plurality of disposable tips in said patient sample supply using said metering system and for dispensing said volume of patient sample into said reaction containment device.

12. An analyzer as recited in claim 11, wherein said third plurality of disposable tips is disposed in a supply between said patient sample supply and said at least one reagent supply.

13. An analyzer as recited in claim 2, wherein said first plurality of disposable tips and said second plurality of disposable tips are each separately disposed on said patient sample supply.

14. An analyzer as recited in claim 11, wherein each of said third plurality of disposable tips are sized to fit within the confines of a said second disposable tip in order to aspirate said volume of patient sample therefrom.

15. An analyzer as recited in claim 11, wherein each of said first plurality of tips are sized to fit within said at least one reaction vessel in order to contact with patient sample already dispensed therein.

16. An analyzer as recited in claim 13, wherein said patient sample supply includes a pair of concentric rotors, a first rotor having a plurality of stations for retaining said first plurality of disposable tips and a second rotor having a plurality of stations for retaining said second plurality of disposable metering tips.

17. An analyzer as recited in claim 16, including a sealing apparatus for sealing the ends of at least one of said pluralities of said first and third disposable tips following dispense of fluid therefrom.

18. An analyzer as recited in claim 17, wherein the sealing apparatus is provided on said patient sample supply.

5. A clinical analyzer comprising:

a sample supply including a first plurality of disposable tips, each of said first plurality of disposable tips having a sealed dispense end forming a container and further having a volume of a patient sample fluid initially contained therein;

at least one reagent supply;

at least one reaction containment device for containing a volume of patient sample fluid from said at least one sample supply and a volume of reagent from said at least one reagent supply; and

reagent wash-free delivery means for aspirating said volume of reagent from said at least one reagent supply and dispensing same into said at least one reaction containment device, wherein said wash-free reagent delivery means includes a second plurality of disposable tips, each of said second plurality of disposable tips being attachable to a metering head movable between said second plurality of disposable tips and said at least one reagent supply for aspirating said volume of reagent from said at least one reagent supply and dispensing aspirated reagent into said at least one reaction containment device, said analyzer further including a third plurality of disposable tips for aspirating patient sample fluid from one of said second plurality of disposable sealed tips and aspirating said volume of patient sample fluid into said at least one reaction containment device.

19. An analyzer as recited in claim 5, wherein said first plurality and said third plurality of disposable tips are each disposed on said sample supply.

20. An analyzer as recited in claim 5, wherein each of said third plurality of disposable tips is sized to permit said tip to be lowered into the confines of a disposable tip from said first plurality of disposable tips to permit patient sample fluid to be aspirated therefrom.

21. An analyzer as recited in claim 5, wherein said sample supply includes a pair of concentric rotors, a first rotor having a plurality of stations for retaining said first plurality of disposable metering tips and a second rotor having a plurality of stations for retaining said second plurality of disposable tips.

22. An analyzer as recited in claim 21, including a sealing apparatus for sealing the ends of at least one of said pluralities of said first and third disposable tips.

23. An analyzer as recited in claim 22, wherein the sealing mechanism is provided on said sample supply.