Bioinformatically detectable group of novel regulatory genes and uses thereof

• US 7,250,496 B2
• Filed: 12/06/2002
• Issued: 07/31/2007
• Est. Priority Date: 11/14/2002
• Status: Active Grant

• Current Assignee: Rosetta Genomics Limited (Rosetta Genomics)
• Original Assignee: Rosetta Genomics Limited (Rosetta Genomics)
• Inventors: Bentwich, Isaac
• Primary Examiner(s): WHITEMAN, BRIAN A
• Application Number:
  US10/310,914
• Publication Number:
  US 20060003322A1
• Time in Patent Office: 1,698 Days
• Field of Search: 536/23.1, 435/320.1
• US Class Current: 536/23.1
• CPC Class Codes: C12N 15/113 Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing when used in plants C12N15/8218
• CPC Class Codes: C12N 2310/14 interfering N.A.
• CPC Class Codes: C12N 2330/10 naturally occurring
• CPC Class Codes: G16B 15/00 ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
• CPC Class Codes: G16B 15/10 Nucleic acid folding
• CPC Class Codes: G16B 20/00 ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• CPC Class Codes: G16B 20/20 Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• CPC Class Codes: G16B 20/30 Detection of binding sites or motifs

Abstract

The present invention relates to a first group of novel genes, here identified as “genomic address messenger” or “GAM” genes, and a second group of novel operon-like genes, here identified as “genomic record” or “GR” genes. GAM genes selectively inhibit translation of known ‘target’ genes, many of which are known to be involved in various diseases. Nucleic acid molecules are provided respectively encoding 20600 GAM genes, and 6635 GR genes, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM and GR genes and specific functions and utilities thereof, for detecting expression of GAM and GR genes, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.

Claims

1. An isolated nucleic acid wherein the sequence of the nucleic acid consists of the sequence of SEQ ID NO:

12003.

2. A vector comprising, a human insert wherein an insert consists of the nucleic acid of claim 1.

3. An isolated first nucleic acid that is the complement of the nucleic acid according to claim 1.

4. A vector comprising an insert, wherein an insert is the nucleic acid of claim 3.