Blood optode

• US 7,251,518 B2
• Filed: 03/10/2004
• Issued: 07/31/2007
• Est. Priority Date: 03/13/2003
• Status: Active Grant

• Current Assignee: Nirlus Engenineering AG
• Original Assignee: Nirlus Engenineering AG
• Inventors: Herrmann, Vera
• Primary Examiner(s): Winakur; Eric
• Assistant Examiner(s): Berhanu; Etsub D
• Application Number:
  US10/547,024
• Publication Number:
  US 20060058595A1
• Time in Patent Office: 1,238 Days
• Field of Search: 600/322, 600/323, 600/328, 600/437, 600/438, 600/473, 600/476
• US Class Current: 600/322
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

A method for measuring in non-invasive manner the concentration of blood constituents by which backscattered light is measured under the action of ultrasonic radiation focused towards the inside of a central blood vessel. A light source and detection unit are arranged to detect the backscattered light on the skin surface above the blood vessel. The target tissue is illuminated by two discrete optical wavelengths. An average light intensity distribution is detected over the length of a pulse. The distribution is Fournier transformed, and the largest Fournier components and spectral position are determined in relation to the frequency of the ultrasonic radiation. The component concentration in the blood vessel is calculated taking into account the volume of the ultrasonic focus contributing to the signal and blood flow rate.

Claims

1. A method for the non-invasive measurement of the concentration of blood constituents in central blood vessels, particularly the hemoglobin concentration or oxygenation of the blood, by measuring backscattered light under the action of ultrasonic radiation, the method comprising:

(a) focusing the ultrasonic radiation on an interior of a central blood vessel;

(b) presetting a fixed pulse length and repetition time for the ultrasonic radiation;

(c) arranging a light source and an adjacent detection unit for detecting the backscattered light on a skin surface over the blood vessel in such a way that a spacing between the light source and a plurality of light receptors of the detection unit correspond to a depth of the examined blood vessel;

(d) illuminating a target tissue with at least two discrete light wavelengths;

(e) measuring the backscattered light intensity in integrating manner over a surface of the detector and a plurality of ultrasonic pulses;

(f) determining an average light intensity distribution over a duration of a pulse;

(g) eliminating time-constant components and carrying out a Fourier transformation of time to frequency coordinates;

(h) drawing conclusions concerning a blood flow rate and its backscattering power for each of the at least two light wavelengths while determining the blood vessel depth;

(i) drawing conclusions concerning the quantity of the blood constituents contributing to a signal from the determined backscattering power; and

(j) calculating concentrations of the blood constituents in the blood vessel while taking account of an ultrasonic focus volume contributing to the signal and the blood flow rate.

2. The method according to claim 1, wherein a volume of a focus contributing to a signal to be measured is reduced on an evaluation side, in that a higher threshold value I_bias is required for an ultrasonic wave field amplitude present at least in the target tissue.

3. The method according to claim 2, wherein a focus position is changed in such a way that the focus traverses a central blood vessel continuously or in several steps, the measurement of the backscattered light intensity during the focus movement or at different focus positions being evaluated so as to determine a degree of tissue blood circulation varying with the position.

4. The method according to claim 1, wherein a focus position is changed in such a way that the focus traverses a central blood vessel continuously or in several steps, the measurement of the backscattered light intensity during the focus movement or at different focus positions being evaluated so as to determine a degree of tissue blood circulation varying with the position.

5. The method according to claim 4, wherein Fourier transformation of the average light intensity distribution in a selected spectral range determines the largest contributing Fourier components and their spectral position.

6. The method according to claim 1, wherein Fourier transformation of the average light intensity distribution in a selected spectral range determines the largest contributing Fourier components and their spectral position.