Imaging method and device employing sherar waves

• US 7,252,004 B2
• Filed: 08/12/2003
• Issued: 08/07/2007
• Est. Priority Date: 09/02/2002
• Status: Expired due to Term

• Current Assignee: SuperSonic Imagine SA (Hologic Incorporated)
• Original Assignee: Centre National De La Recherche Scientifique, Universite Paris - Sud
• Inventors: Tanter, Mickael, Fink, Mathias A.
• Primary Examiner(s): Williams; Hezron
• Assistant Examiner(s): SAINT SURIN, JACQUES M
• Application Number:
  US10/526,407
• Publication Number:
  US 20050252295A1
• Time in Patent Office: 1,456 Days
• Field of Search: 735/97, 736/02, 736/25, 736/26, 600/443, 600/438, 600/447, 600/587
• US Class Current: 73/597
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/485 involving measuring strain or elastic properties
• CPC Class Codes: G01N 2291/02827 Elastic parameters, strength or force
• CPC Class Codes: G01S 15/8915 using a transducer array
• CPC Class Codes: G01S 7/52022 using a sequence of pulses, at least one pulse manipulating the transmissivity or reflexivity of the medium
• CPC Class Codes: G01S 7/52042 determining elastic properties of the propagation medium or of the reflective target diagnostic techniques involving the measurement of strain A61B8/485
• CPC Class Codes: G01S 7/52071 Multicolour displays; using colour coding; Optimising colour or information content in displays, e.g. parametric imaging

Abstract

An imaging method for observing the propagation of a shear wave simultaneously at a multitude of points in a diffusing viscoelastic medium. The shear wave is caused to be generated by firing at least one focused ultrasound compression wave into the viscoelastic medium by means of an array of transducers, and then emitting at a fast rate and using the same array of transducers, unfocused ultrasound compression waves serving to obtain a succession of images of the medium, and processing the images obtained in this way in deferred time in order to determine the movements of the medium during the propagation of the shear wave.

Claims

1. An imaging method using shear waves for observing a diffusing viscoelastic medium containing particles that reflect ultrasound compression waves, said method comprising:

a) an excitation step during which an elastic shear wave is generated in the viscoelastic medium;

b) an observation step during which the propagation of the shear wave is observed simultaneously at a multitude of points in an observation field in the viscoelastic medium, this observation step comprising the following substeps;

b1) causing an array of transducers that are controlled independently of one another to emit into the viscoelastic medium a succession of unfocused ultrasound compression wave shots at a rate of at least 500 shots per second; and

b2) causing sound signals received from the viscoelastic medium to be detected and recorded in real time, said signals comprising the echoes generated by the unfocused ultrasound compression wave interacting with the reflecting particles in said viscoelastic medium; and

c) at least one processing step during which;

c1) the sound signals received successively from the viscoelastic medium during substep b2) are processed in order to determine successive propagation images of the shear wave; and

c2) at least one movement parameter of the viscoelastic medium is determined at different points of the observation field;

the method further comprising;

during the excitation step a) the elastic shear wave is caused to be generated by causing at least one focused ultrasound wave to be emitted into the viscoelastic medium by said array of transducers, the focusing and the timing of said focused ultrasound wave, and the timing of said unfocused ultrasound wave being adapted so that at least some of said unfocused ultrasound waves penetrate into the observation field while the shear wave is propagating in the observation field, for at least some of the unfocused ultrasound wave emissions.

2. A method according to claim 1, in which during substep b2), in order to determine said movement parameter, plurality of successive propagation images are compared with a common reference image of the viscoelastic medium, the reference image being determined by firing at least one unfocused ultrasound compression wave into said viscoelastic medium and then detecting and recording echoes generated by said unfocused ultrasound compression wave on interacting with the reflecting particles in the viscoelastic medium.

3. A method according to claim 2, in which step a) is preceded by an initial observation step a0) during which at least one unfocused ultrasound compression wave is fired and then echoes generated by said unfocused ultrasound compression wave interacting with the reflecting particles in the viscoelastic medium are detected and recorded, said echoes corresponding to an initial image of the viscoelastic medium, and during substep b2), said initial image constitutes said reference image for processing at least some of the successive displacement images.

4. A method according to claim 3, in which, during initial observation step a0), a plurality of unfocused ultrasound compression waves are fired in succession and then echoes generated by each unfocused ultrasound compression wave interacting with the reflecting particles of the viscoelastic medium are detected and recorded, said echoes corresponding to a plurality of successive images of the viscoelastic medium, and said initial image of the viscoelastic medium is determined by combining said successive images.

5. A method according to claim 1, in which said movement parameter is a displacement of the viscoelastic medium.

6. A method according to claim 1, in which the focused ultrasound wave emitted during excitation step a) presents a frequency flying in the range 0.5 MHz to 15 MHz, and is emitted for a duration of k/f seconds, where k is an integer lying in the range 50 to 5000 and f is expressed in Hz.

7. A method according to claim 1, in which the focused ultrasound wave emitted during excitation step a) presents a frequency lying in the range 0.5 MHz to 15 MHz and is emitted during a succession of emission periods separated by rest periods, the emission periods following one another at a rate lying in the range 10 to 1000 emissions per second.

8. A method according to claim 1, in which the focused ultrasound wave emitted during excitation step a) is a linear combination (in particular a sum) of two monochromatic signals having respective frequencies f1 and f2 such that 20 Hz≦

|f1−

f2|≦

1000 Hz.

9. A method according to claim 1, in which the focused ultrasound wave emitted during excitation step a) is focused simultaneously on a plurality of points.

10. A method according to claim 1, in which image processing step c) is followed by a mapping step d) during which, on the basis of variation in the movement parameter over time, at least one shear wave propagation parameter is calculated at at least some points of the observation field in order to determine a map of said propagation parameter in the observation field.

11. A method according to claim 1, in which the shear wave propagation parameter which is calculated during mapping step d) is selected from shear wave speed, shear modulus, Young'"'"'s modulus, shear wave attenuation, shear elasticity, shear viscosity, and mechanical relaxation time.

12. A method according to claim 11, in which steps a) to d) are repeated successively while emitting different focused ultrasound waves during successive excitation step a), and then combining the maps obtained during the successive mapping step d) in order to calculate a combination map of the observation field.

13. Imaging apparatus for implementing a method according to claim 1 using shear waves to observe a diffusing viscoelastic medium containing particles that reflect ultrasound compression waves, the apparatus comprising an array of transducers that are controlled independently of one another by at least one electronic central unit adapted:

to cause at least one elastic shear wave to be generated in the viscoelastic medium;

to observe the propagation of the shear wave simultaneously at a multitude of points in an observation field in the viscoelastic medium by causing said array of transducers to emit into the viscoelastic medium a succession of unfocused ultrasound compression wave shots at a rate of at least 500 shots per second, then causing said array of transducers to detect in real time and to record in real time sound signals received from the viscoelastic medium, the sound signals comprising the echoes generated by the unfocused ultrasound compression wave interacting with the reflecting particles of said viscoelastic medium; and

processing the successive sound signals received from the viscoelastic medium to determine successive propagation images of the shear wave, and then determinine at least one movement parameter of the viscoelastic medium at different points of the observation field;

and further wherein the electronic central unit is adapted to cause the elastic shear wave to be generated by causing at least one focused ultrasound wave to be emitted into the viscoelastic medium by said array of transducers, the focusing and the timing of said focused ultrasound wave, and the timing of said unfocused ultrasound wave being adapted so that said unfocused ultrasound waves reach the observation field during the propagation of the shear wave through the observation field.