Method for continuous monitoring of patients to detect the potential onset of sepsis

• US 7,252,637 B2
• Filed: 02/17/2006
• Issued: 08/07/2007
• Est. Priority Date: 03/22/2002
• Status: Expired due to Fees

• Current Assignee: Mini-Mitter Co., Inc. (Respironics Incorporated)
• Original Assignee: Mini-Mitter Co., Inc. (Respironics Incorporated)
• Inventors: McKenzie, Jack E., Ebner, Dennis M.
• Primary Examiner(s): Marmor, II; Charles A.
• Assistant Examiner(s): Mallari; Patricia C
• Application Number:
  US11/356,792
• Publication Number:
  US 20060155176A1
• Time in Patent Office: 536 Days
• Field of Search: None
• US Class Current: 600/301
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B

Abstract

A method of screening for possible onset of sepsis in a patient includes providing the patient with a transducer that automatically and periodically measures a first physiological parameter of the patient and transmits a first signal that is encoded with the measured parameter value, and receiving the first signal and automatically comparing the measured parameter value with at least one alarm limit. The first physiological parameter is body temperature, heart rate, respiration rate or a clinical indicator of sepsis. A conditional warning signal is asserted in the event that the measured parameter value bears a predetermined relationship to said alarm limit and an alarm signal is issued in the event that a physiological condition other than the condition that gave rise to the conditional warning signal is indicative of onset of sepsis.

Claims

1. A method of screening for possible onset of sepsis in a patient, comprising:

(a) providing a first transducer that automatically measures the heart interbeat interval of such a patient,

(b) calculating a value representative of heart rate variability for such a patient,

(c) issuing a conditional warning in the event that the calculated value representative of heart rate variability bears a predetermined relationship to a reference value of heart rate variability,

(d) providing a second transducer that automatically measures a core temperature of such a patient,

(e) providing a third transducer that automatically measures a dermal temperature of the patient,

(f) comparing the measured core temperature with the measured dermal temperature,

(g) generating an alarm signal in the event that the measured core temperature value bears a predetermined relationship to the measured reference dermal temperature value and the conditional warning was issued in step (c), and

(h) if the alarm signal is generated in step (g), testing the patient for onset of sepsis.

2. The method of claim 1, wherein providing a second transducer further comprises intermittently transmitting a signal that is encoded with a value representative of the measured core temperature.

3. The method of claim 2, wherein providing a third transducer further comprises intermittently transmitting a signal that is encoded with a value representative of the measured dermal temperature value.

4. The method of claim 3, wherein comparing the measured core temperature with the measured dermal temperature further comprises:

receiving the signal that is encoded with a value representative of the measured core temperature and the signal that is encoded with a value representative of the measured dermal temperature value, and

comparing the signal that is encoded with a value representative of the measured core temperature with the signal that is encoded with a value representative of the measured dermal temperature value.

5. A method of screening for possible onset of sepsis in a patient, comprising:

(a) measuring a heart interbeat interval for such a patient,

(b) calculating, responsive to the measured heart interbeat interval, a heart rate variability value for such a patient,

(c) measuring a core temperature and a reference dermal temperature for such a patient,

(d) comparing the measured core temperature with the measured reference dermal temperature, and

(e) generating a conditional warning in the event that one of;

(1) the calculated heart rate variability value bears a predetermined relationship to a reference heart rate variability value; and

(2) the measured core temperature value bears a predetermined relationship to the measured reference dermal temperature value,

(f) generating an alarm signal in the event that both of;

(1) the calculated heart rate variability value bears a predetermined relationship to the reference heart rate variability value; and

(2) the measured core temperature value bears a predetermined relationship to the measured reference dermal temperature value, and

(g) testing the patient for onset of sepsis if the alarm signal is generated.

6. The method of claim 5, further comprising testing the patient for onset of sepsis if the conditional warning is generated.