Light generating device to intravascular use

• US 7,252,677 B2
• Filed: 03/12/2004
• Issued: 08/07/2007
• Est. Priority Date: 03/14/2003
• Status: Expired due to Fees

• Current Assignee: Light Sciences Oncology, Inc.
• Original Assignee: Light Sciences Oncology, Inc.
• Inventors: Narciso, Hugh, Burwell, Phillip, Lichttenegger, Gary, Guo, Zihong, Yeo, Nick, Shine, David B., Bishop, Jean, Matson, Jennifer Kristine, Daly, Steven Ross
• Primary Examiner(s): Johnson, III; Henry M
• Application Number:
  US10/799,357
• Publication Number:
  US 20050228260A1
• Time in Patent Office: 1,243 Days
• Field of Search: 607 88- 94, 606 10- 19
• US Class Current: 607/88
• CPC Class Codes: A61B 2018/2261 with scattering, diffusion or dispersion of light
• CPC Class Codes: A61N 2005/0602 for treatment of blood vessels
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/1003 having means for centering a radioactive source within the lumen, e.g. balloons
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

Claims

1. Apparatus for illuminating a portion of a body lumen to which a photoreactive agent has been or will be administered, comprising:

(a) an elongate, flexible body having a proximal end, a distal end, and at least one lumen extending therebetween;

(b) a light source array having a proximal end and a distal end, the light source array emitting light directed toward the distal end of the elongate, flexible body, said light having a characteristic emission waveband, where the characteristic emission band corresponds to a characteristic absorption waveband of the photoreactive agent, the light source array being disposed adjacent to the distal end of the elongate, flexible body;

(c) an electrical lead having a proximal end adapted to be electrically coupled to an external power supply, and a distal end electrically coupled to the light source array, thereby enabling the light source array to be energized with an electrical current when the proximal end of the electrical lead is electrically coupled to the external power supply;

(d) a light diffusing element having a proximal end and a distal end, the proximal end of the light diffusing element being oriented in a facing relationship with the distal end of the light source array, such that light emitted from the light source array is diffused and directed outwardly away from the light diffusing element; and

(e) an optical fiber having a proximal end, and a distal end, the proximal end of the optical fiber facing toward the distal end of the light source array, and the distal end of the optical fiber directing light from the light source array to the light diffusing element.

2. The apparatus of claim 1, wherein the optical fiber is tapered, such that the distal end of the optical fiber has a smaller cross-section than the proximal end of the optical fiber.

3. The apparatus of claim 1, wherein the optical fiber comprises a bundle of optical fibers.

4. The apparatus of claim 1, further comprising an optical element having a proximal side and a distal side, the proximal side of the optical element facing toward the distal end of the light source array, and the optical element focusing light emitted from the light source array.

5. The apparatus of claim 1, wherein the light diffusing element is generally cylindrical.

6. The apparatus of claim 1, wherein the light diffusing element comprises a plurality of light diffusing members.

7. The apparatus of claim 1, wherein the light source array comprises a plurality of light emitting devices and conductive traces electrically coupling the plurality of light emitting devices to the electrical lead, thereby enabling the light emitting devices to be energized with the electrical current from an external power source.

8. The apparatus of claim 1, further comprising:

(a) an expandable member substantially encompassing the light diffusing element; and

(b) an inflation lumen extending between the proximal end of the elongate, flexible body and the expandable member.

9. The apparatus of claim 8, wherein the inflation lumen further extends between the distal and proximal ends of the light source array.

10. The apparatus of claim 8, wherein the inflation lumen further extends between the elongate, flexible body and the light diffusing element, through any intervening element included in the apparatus.

11. The apparatus of claim 1, wherein the light source array comprises reflective elements configured to reflect light emitted by the light source array toward the distal end of the light source array, increasing an intensity of light emitted from the distal end of the light source array.

12. Apparatus for illuminating a portion of a body lumen to which a photoreactive agent has or will be administered, comprising:

(a) an elongate, flexible body having a proximal end, a distal end, and at least one lumen;

(b) a light source element disposed adjacent to the distal end of the elongate, flexible body, the light source element being electrically coupled to an electrical lead that is adapted to couple to an external power supply, to enable the light source element to be energized with an electrical current, thereby illuminating at least a portion of the body lumen, the light source element emitting light having a characteristic emission waveband corresponding to a characteristic absorption waveband of the photoreactive a gent, the light source element having a proximal end, and a distal end, the distal end of the light source element facing toward the distal end of the elongate, flexible body;

(c) a light diffusing element having a proximal end and a distal end, the proximal end of the light diffusing element facing toward the distal end of the light source element, so that light emitted from the light source element is diffused and directed outwardly away from the light diffusing element; and

(d) an optical fiber having a proximal end, and a distal end, the proximal end of the optical fiber facing toward the distal end of the light source element, and the distal end of the optical fiber facing toward the proximal end of the light diffusing element, the optical fiber directing light from the light source element to the light diffusing element.

13. The apparatus of claim 12, wherein the light source element includes a plurality of light sources.

14. The apparatus of claim 13, wherein the plurality of light sources are each light emitting devices.

15. The apparatus of claim 13, wherein the plurality of light sources are configured in a radial array.

16. The apparatus of claim 13, wherein the plurality of light sources include at least one first type of light source emitting light of a first wavelength, and a second type of light source emitting light of a second wavelength.

17. The apparatus of claim 12, further comprising at least one light sensor.

18. The apparatus of claim 12, further comprising:

(a) an expandable member substantially encompassing the light diffusing element; and

(b) an inflation lumen extending between the proximal end of the elongate, flexible body and the expandable member, in fluid communication with a volume encompassed by the expandable member.

19. The apparatus of claim 12, wherein the optical fiber is tapered, such that the distal end of the optical fiber has a smaller cross-section than the proximal end of the optical fiber.

20. The apparatus of claim 12, further comprising an optical element having a proximal side, and a distal side, the proximal side of the optical element facing toward the distal end of the light source element, said optical element focusing light emitted from the light source element.

21. The apparatus of claim 12, further comprising:

(a) an expandable member substantially encompassing the light source element; and

(b) an inflation lumen extending between the proximal end of the elongate, flexible body and the expandable member, in fluid communication with a volume encompassed by the expandable member.

22. Apparatus for illuminating a portion of a body lumen to which a photoreactive agent has been or will be administered, comprising:

(a) an elongate, flexible body having a proximal end, a distal end, and at least one lumen extending therebetween;

(b) a light source array having a proximal end, and a distal end, the light source array emitting light directed toward the distal end of the elongate, flexible body, said light having a characteristic emission waveband, where the characteristic emission waveband corresponds to a characteristic absorption waveband of the photoreactive agent, the light source array being disposed adjacent to the distal end of the elongate, flexible body;

(c) an electrical lead having a proximal end adapted to be electrically coupled to an external power supply, and a distal end electrically coupled to the light source array, thereby enabling the light source array to be energized with an electrical current when the proximal end of the electrical lead is electrically coupled to the external power supply;

(d) an optical element having a proximal side, and a distal side, the proximal side of the optical element facing toward the distal end of the light source element, said optical element focusing light emitted from the light source element; and

(e) a light diffusing element having a proximal end, and a distal end, the proximal end of the light diffusing element being oriented in a facing relationship with the distal end of the light source array, such that light emitted from the light source array and focused by the optical element is diffused and directed outwardly away from the light diffusing element.

23. Apparatus for illuminating a portion of a body lumen to which a photoreactive agent has or will be administered, comprising:

(a) an elongate, flexible body having a proximal end, a distal end, and at least one lumen;

(b) a light source element disposed adjacent to the distal end of the elongate, flexible body, the light source element being electrically coupled to an electrical lead that is adapted to couple to an external power supply, to enable the light source element to be energized with an electrical current, thereby illuminating at least a portion of the body lumen, the light source element emitting light having a characteristic emission waveband corresponding to a characteristic absorption waveband of the photoreactive agent, the light source element having a proximal end, and a distal end, the distal end of the light source element facing toward the distal end of the elongate, flexible body;

(c) an optical element having a proximal side, and a distal side, the proximal side of the optical element facing toward the distal end of the light source element, said optical element focusing light emitted from the light source element; and

(d) a light diffusing element having a proximal end, and a distal end, the proximal end of the light diffusing element facing toward the distal end of the light source element, so that light emitted from the light source element is diffused and directed outwardly away from the light diffusing element.