Hemostatic wound dressing and method of making same

• US 7,252,837 B2
• Filed: 06/28/2002
• Issued: 08/07/2007
• Est. Priority Date: 06/28/2002
• Status: Expired due to Term

• Current Assignee: Ethicon Incorporated (Johnson & Johnson)
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Zhang, Guanghui, Looney, Dwayne Lee, Gorman, Anne Jessica, Guo, Jian Xin
• Primary Examiner(s): GHALI, ISIS A D
• Application Number:
  US10/186,021
• Publication Number:
  US 20040001879A1
• Time in Patent Office: 1,866 Days
• Field of Search: 424/443, 424484-489
• US Class Current: 424/443
• CPC Class Codes: A61L 15/28 Polysaccharides or their derivatives A61L15/225 takes precedence
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: C08L 1/04 Oxycellulose; Hydrocellulose , e.g. microcrystalline cellulose
• CPC Class Codes: C08L 1/16 Esters of inorganic acids
• CPC Class Codes: C08L 1/284 with hydroxylated hydrocarbon radicals
• CPC Class Codes: C08L 2666/26 Natural polymers, natural resins or derivatives thereof according to C08L1/00 - C08L5/00, C08L89/00, C08L93/00, C08L97/00 or C08L99/00
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: Y10T 442/2525 Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

Abstract

The present invention is directed to wound dressings that contain a fabric made from biocompatible polymeric fibers and having flexibility, strength and porosity effective for use as a hemostat, and a porous, polymeric matrix prepared from a biocompatible, water-soluble or water-swellable polymer dispersed through the fabric; and to methods of making such wound dressings.

Claims

1. A process for making a wound dressing for use with moderate to severe bleeding, the wound dressing comprising a fabric that comprises oxidized regenerated cellulose fibers and a biocompatible, water-soluble or water-swellable polymer matrix of sodium carboxymethyl cellulose, the process consisting of the steps of:

providing a solution having dissolved therein sodium carboxymethyl cellulose,

providing a fabric having a top surface and a bottom surface opposing said top surface, said fabric having flexibility, strength and porosity effective for use as a hemostat,

immersing said fabric at least partially in said solution to distribute said solution at least partially through said fibers,

lyophilizing said fabric and said solution distributed at least partially through said fibers, thereby forming a porous polymeric matrix at least partially integrated with or about the fibers having a microporous structure with a large fluid absorbing capacity.

2. The process of claim 1 wherein said fabric is knitted.

3. The process of claim 1 wherein the weight ratio of said sodium carboxymethyl cellulose to said fabric is from about 1:

99 to about 20;

80.

4. The process of claim 3 wherein the weight ratio of said sodium carboxymethyl cellulose to said fabric is from about 3:

97 to about 10;

90.

5. A hemostatic wound dressing made in accordance with the process of claim 1.

6. The wound dressing of claim 5 wherein the fibers are woven or nonwoven.

7. The wound dressing of claim 5 wherein the fibers are knitted.

8. The wound dressing of claim 5 wherein the weight ratio of said sodium carboxymethyl cellulose to said fabric is from about 1:

99 to about 20;

80.

9. The wound dressing of claim 8 wherein the weight ratio of said sodium carboxymethyl cellulose to said fabric is from about 3:

97 to about 10;

90.