Methods and devices for producing a polymer at a location of a substrate
First Claim
1. A method for determining relative misalignment of a fluid deposition device during polymer production on the surface of a substrate, said method comprising:
- (a) depositing a fluid droplet containing a first monomer labeled with a first detectable label from a fluid deposition device onto an intended deposition location of a substrate surface to produce a polymer at said intended deposition location, wherein said intended deposition location comprises a second monomer labeled with a second detectable label and said first and second detectable labels are distinguishable from each other; and
(b) detecting said first and second detectable labels to determine any relative misalignment between said fluid deposition device and said intended deposition location to determine relative misalignment of said fluid deposition device during polymer production on the surface of said substrate.
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Abstract
Methods and devices for producing a polymer at a location of a substrate are provided. In the subject methods, a fluid droplet containing a first monomer labeled with a first detectable label is deposited from a fluid deposition device onto a location of a substrate surface having a second monomer labeled with a second detectable label. The first and second detectable labels are then detected to determine any misalignment between the fluid deposition device and the location of the substrate surface during deposition. Also provided are algorithms that perform the subject methods, as well as fluid deposition devices that include the subject algorithms. The subject invention also includes arrays produced according to the subject methods and kits that include the subject arrays.
57 Citations
20 Claims
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1. A method for determining relative misalignment of a fluid deposition device during polymer production on the surface of a substrate, said method comprising:
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(a) depositing a fluid droplet containing a first monomer labeled with a first detectable label from a fluid deposition device onto an intended deposition location of a substrate surface to produce a polymer at said intended deposition location, wherein said intended deposition location comprises a second monomer labeled with a second detectable label and said first and second detectable labels are distinguishable from each other; and (b) detecting said first and second detectable labels to determine any relative misalignment between said fluid deposition device and said intended deposition location to determine relative misalignment of said fluid deposition device during polymer production on the surface of said substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification