Electrically conductive polymeric biomaterials, the process for their preparation and the use thereof in the biomedical and healthcare field
First Claim
1. A composite biomaterial constituted by:
- (a) an electrically conductive polymer film based on polypyirole (PPy) and at least one compound chosen from the group formed by hyaluronic acid, ester derivatives of hyaluronic acid (HYAFF), O-sulphated derivatives of hyaluronic acid (HAOSO3), or percarboxylated derivatives of hyaluronic acid (HYOXX) and,(B) a two- or three-dimensional structure constituted by at least one ester derivatives of hyaluronic acid (HYAFF), percarboxylated derivatives of hyaluronic acid (HYOXX), autocrosslinked derivatives of hyaluronic acid (ACP), or crosslinked derivatives of partially deacetylated hyaluronic acid.
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Abstract
The present invention concerns the preparation of composite biomaterials constituted by hyaluronic acid and the derivatives thereof in combination with polymers that have electrically conductive properties. In particular, the methods of preparing biomedical devices formed by a two- or three-dimensional polysaccharide matrix and by an electrically conductive membrane. The matrix is constituted by hyaluronic acid derivatives in the form of membranes, woven fabrics, nonwoven felts, meshes, gauzes, guide channels or sponges, while the electrically conductive membrane is constituted by a film of polypyrrole (polymer conductor) in combination with hyaluronic acid or a derivative thereof (doping agent).
29 Citations
20 Claims
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1. A composite biomaterial constituted by:
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(a) an electrically conductive polymer film based on polypyirole (PPy) and at least one compound chosen from the group formed by hyaluronic acid, ester derivatives of hyaluronic acid (HYAFF), O-sulphated derivatives of hyaluronic acid (HAOSO3), or percarboxylated derivatives of hyaluronic acid (HYOXX) and, (B) a two- or three-dimensional structure constituted by at least one ester derivatives of hyaluronic acid (HYAFF), percarboxylated derivatives of hyaluronic acid (HYOXX), autocrosslinked derivatives of hyaluronic acid (ACP), or crosslinked derivatives of partially deacetylated hyaluronic acid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A composite biomaterial consisting of polypyrrole and biocompatible, macromolecular counterions selected from PSS, HA, HYOXX, HAOSO3 and derivatives thereof deposited on titanium or titanium alloys for use in the orthopaedic field and in bone tissue regeneration.
Specification