Enzymatic method to produce 7-dehydropregnenolone, vitamin D3-like compounds and derivatives thereof
First Claim
Patent Images
1. A compound that is 5Z,7E-3β
- ,11α
-dihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11β
-dihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3,17β
-dihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3,β
,21-dihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,17β
,21-trihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11α
,17β
-trihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11β
,17β
-trihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11α
,21-trihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11β
,21-trihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11α
,17β
,21-tetrahydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11β
,17β
,21-tetrahydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 3-keto-17-hydroxyetiocalciferal or 3,17-diketoetiocalciferol.
2 Assignments
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Accused Products
Abstract
Provided herein are enzymatic methods of producing steroid compounds such as 7-dehydropregnenolone, hydroxy derivatives thereof and vitamin D2- and D3-like compounds and derivatives thereof. Also provided are the derivatives of the vitamin D3-like compounds so generated via the action of cytochrome P450scc enzyme on substrates 7-dehydrocholesterol, vitamin D2 or vitamin D3.
8 Citations
1 Claim
-
1. A compound that is 5Z,7E-3β
- ,11α
-dihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11β
-dihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3,17β
-dihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3,β
,21-dihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,17β
,21-trihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11α
,17β
-trihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11β
,17β
-trihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11α
,21-trihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11β
,21-trihydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11α
,17β
,21-tetrahydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 5Z,7E-3β
,11β
,17β
,21-tetrahydroxy-9,10-secopregna-5,7,10(19)trien-20-one, 3-keto-17-hydroxyetiocalciferal or 3,17-diketoetiocalciferol.
- ,11α
Specification
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Current AssigneeUniversity of Tennessee Research Foundation (University of Tennessee)
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Original AssigneeUniversity of Tennessee Research Foundation (University of Tennessee)
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InventorsSlominski, Andrzej, Zjawiony, Jordan, Wortsman, Jacobo, Stewart, D. Jeremy, Tuckey, Robert
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Primary Examiner(s)Badio; Barbara P.
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Application NumberUS11/031,844Publication NumberTime in Patent Office943 DaysField of Search552/606, 552/653US Class Current552/653CPC Class CodesC12P 33/00 Preparation of steroidsC12P 33/005 Degradation of the lateral ...C12P 7/02 containing a hydroxy group
