Chloride channel opener

• US 7,253,295 B2
• Filed: 01/18/2006
• Issued: 08/07/2007
• Est. Priority Date: 08/31/2001
• Status: Expired due to Term

• Current Assignee: Sucampo AG (Mallinckrodt plc)
• Original Assignee: Sucampo AG (Mallinckrodt plc)
• Inventors: Ueno, Ryuji, Cuppoletti, John
• Primary Examiner(s): McKane; Joseph K.
• Assistant Examiner(s): SHIAO, REI TSANG
• Application Number:
  US11/333,511
• Publication Number:
  US 20060122411A1
• Time in Patent Office: 566 Days
• Field of Search: 554/61
• US Class Current: 554/61
• CPC Class Codes: A61K 31/557 Eicosanoids, e.g. leukotrienes or prostaglandins
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 11/08 Bronchodilators
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 21/02 Muscle relaxants, e.g. for tetanus or cramps
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 3/14 for calcium homeostasis vitamin D A61P3/02; parathyroid hormones A61P5/18; calcitonin A61P5/22; osteoporosis A61P19/10; bone metastasis A61P35/04
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07C 405/00 Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Abstract

Disclosed is a novel use of a prostaglandin compound as a chloride channel opener. According to the instant invention, chloride channels in a mammalian subject can be opened by a prostaglandin compound to facilitate chloride ion transportation.

Claims

1. A compound represented by formula (IV):

2. The compound as described in claim 1, wherein said compound is 13,14-dihydro-15-keto-16,16-difluoro-PGE₁ N-ethyl amide.

3. The compound as described in claim 1, wherein said compound is 13,14-dihydro-15-keto-16,16-difluoro-PGF_1α

N-ethyl amide.

4. The compound as described in claim 1, wherein said compound is 13,14-dihydro-15-keto-17-phenyl-18,19,20-trinor-PGF_2α

N-ethyl amide.

5. The compound as described in claim 1, wherein said compound is 13,14-dihydro-15-keto-20-ethyl-PGF_2α

N-ethyl amide.