Detection, diagnosis, and monitoring of a medical condition or disease with artificial olfactometry

• US 7,255,677 B2
• Filed: 03/04/2003
• Issued: 08/14/2007
• Est. Priority Date: 03/04/2002
• Status: Expired due to Fees

• Current Assignee: Smiths Detection (Smiths Group International Holdings Ltd.), Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Original Assignee: Smiths Detection (Smiths Group International Holdings Ltd.), Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Inventors: Thaler, Erica R., Burch, Timothy E., Hanson, C. William III
• Primary Examiner(s): Hindenburg; Max F.
• Assistant Examiner(s): Astorino; Michael C.
• Application Number:
  US10/382,360
• Publication Number:
  US 20040006257A1
• Time in Patent Office: 1,624 Days
• Field of Search: 600/300, 600/301, 600529-538, 128/898, 128/920, 422/84, 73/233
• US Class Current: 600/300
• CPC Class Codes: A61B 5/00 Measuring for diagnostic purposes radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00; Identification of persons
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/4547 Evaluating teeth
• CPC Class Codes: G01N 33/0036 Specially adapted to detect a particular component all the other sub-groups of G01N33/0004 take precedence
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath

Abstract

Methods and devices for rapid diagnosis and monitoring a patient for disease or effectiveness of treatment in real time. In preferred embodiments, the methods and devices comprise contacting an array of sensors with a sample from a mammal suspected of having a disease to generate a sensor array profile, measuring a clinical diagnostic marker for the suspected disease, and then developing a diagnosis using the sensor array profile in combination with the clinical diagnostic marker.

Claims

1. A method for determining whethcr a mammal has a disease, said method comprising:

(a) contacting an array of sensors with a sample from a mammal suspected of having a disease to generate a first sensor array response profile; and

(b) comparing said first sensor array response profile with a sensor array profile from a health mammal, thereby determining whether said mammal suspected of having a disease actually has said disease,

wherein the array of sensors includes a chemical sensor electrically ccupled to first and second conductive leads, and

wherein the contacting step comprises;

a1) measuring a first response between the first and second conductive leads when the chemical sensor is contacted with a first marker gas at a first concentration; and

a2) measuring a second response between the first and second conductive leads when the chemical sensor is contacted with the first marker gas at a second concentration different from the first concentration; and

a3) generating the sensor array response profile based on the first and second responses.

2. The method of claim 1, wherein the first and second responses are responses obtained from the array of sensors that are measured by changes in magnetic or optical characteristics of the array of sensors.

3. A method for determining whether a mammal has a disease, said method comprising:

(a) contacting an array of sensors with a sample from a first plurality of mammals suspected of having a disease to generate a first sensor array response profile;

(b) contacting the array of sensors with a sample from a second plurality of mammals not suspected of having a disease to generate a second sensor array response profile; and

(c) contacting the array of sensors with a sample from the mammal for which a determination is to be made as to whether or not the mammal has the disease, to generate a third sensor array profile;

(d) evaluating the difference between the first and second sensor array profiles with respect to the third sensor array profile, respectively, thereby determining whether not the mammal has the disease,

wherein the array of sensors includes a chemical sensor electrically coupled to first and second conductive leads, and

wherein the contacting step comprises;

a1)measuring a first response between the first and second conductive leads when the chemical sensor is contacted with a first marker gas at a first concentration; and

a2) measuring a second response between the first and second conductive leads when the chemical sensor is contacted with the first marker gas at a second concentration different from the first concentration; and

a3) generating the first and second sensor array response profit s based on the first and second responses.

4. The method of claim 3, where in the array of sensors includes a chemical sensor electrically coupled to first and second conductive leads, and

wherein each of the contacting steps comprises:

a1) measuring a first response between the first and second conductive leads when the chemical sensor is contacted with a first marker gas at a first concentration; and

a2) measuring a second response between the first and second conductive leads when the chemical sensor is contacted with the first marker gas at a second concentration different from the first concentration; and

a3) generating the respective first and second sensor array response profiles based on die first and second responses.

5. The method of claim 3, wherein the first and second responses are responses obtained from the array of sensors that are measured by changes in magnetic or optical characteristics of the array of sensors.

6. A method for detecting a physiological condition in a mammal, said method comprising:

(a) contacting an array of sensors with a sample from a first mammal suspected of having a physiological condition to generate a baseline sensor array response profile;

(b) measuring a clinical diagnostic marker for said physiological condition; and

(c) determining the severity of the physiological condition using said sensor array response profile in combination with said clinical diagnostic marker;

(d) contacting the array of sensors with a sample from a second mammal having a disease for a second time to generate a second sensor array response profile;

(c) measuring said clinical diagnostic marker for said disease for a second time; and

(f) determining the severity of the disease in said second mammal using said first and second sensor array response profiles in combination with the first and second measurement of said clinical diagnostic marker, thereby monitoring said disease in said second mammal.

7. A method for detecting presence or absence of a physiological condition in a mammal, said method comprising:

(a) contacting an array of sensors with a sample from a mammal suspected of having a physiological condition to generate a sensor array response profile;

(b) measuring a clinical diagnostic marker for said physiological condition; and

(c) developing a diagnosis using said sensor array response profile in combination wit said clinical diagnostic marker, thereby detecting the presence or absence of said physiological condition in said mammal,

wherein the array of sensors includes a chemical sensor electrically coupled to first and second conductive leads, and

wherein the contacting step comprises;

a1) measuring a first response between the first and second conductive leads when the chemical sensor is contacted with a first marker gas at a first concentration; and

a2) measuring a second response between the first and second conductive leads when the chemical sensor is contacted with the first marker gas at a second concentration different from the first concentration; and

a3) generating the sensor array response profile based on the first and second responses.

8. The method of claim 7, wherein the first and second responses are responses obtained from the array of sensors that are measured by changes in magnetic or optical characteristics of the array of sensors.