Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto

• US 7,255,874 B1
• Filed: 12/21/2001
• Issued: 08/14/2007
• Est. Priority Date: 12/21/2001
• Status: Expired due to Fees

• Current Assignee: Ethicon Incorporated (Johnson & Johnson)
• Original Assignee: Closure Medical Corporation (Johnson & Johnson)
• Inventors: Clark, Jeffrey G., Marmo, J. Christopher, Jonn, Jerry Y., Quintero, Julian A., Cannizaro, Scott Marc, Bobo, John S., Barefoot, Joe B., Narang, Upvan
• Primary Examiner(s): Woodward; Michael
• Assistant Examiner(s): Barham; Bethany P
• Application Number:
  US10/024,143
• Time in Patent Office: 2,062 Days
• Field of Search: None
• US Class Current: 424/450
• CPC Class Codes: A61K 9/5026 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61L 24/06 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043, A61L24/046 take precedence
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: C08L 35/04 Homopolymers or copolymers of nitriles C08L35/06, C08L35/08 take precedence

Abstract

Biocompatible polymers and adhesives have a cyanoacrylic core and other substituents such as therapeutic agents, targeting moieties, imaging agents, amino acid residues or other organic moieties. Exemplary uses of inventive compositions include use as sealants and adhesives for medical uses, and as polymeric formulations for biocompatible implants and matrices and drug delivery.

Claims

1. A composition comprising a chemical moiety comprising the structure:

3. The composition of claim 1, wherein said residue is of an amino acid selected from the group consisting or glycine, alanine, valine, cysteine, leucine, isoleucine, serine, threonine, methionine, glutamic acid, aspartic acid, glutamine, asparagine, lysine, arginine, proline, histidine, phenylalanine, tyrosine, tryptophan, and an analog, derivative or congener of any of the foregoing.

2. A composition comprising a chemical moiety comprising the structure:

4. The composition of claim 2, wherein said amino acid is an (L) stereoisomer.