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Modulation of apolipoprotein (a) expression

  • US 7,259,150 B2
  • Filed: 10/15/2003
  • Issued: 08/21/2007
  • Est. Priority Date: 08/07/2001
  • Status: Expired due to Term
First Claim
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1. A method of inhibiting the expression of apolipoprotein(a) in a cell or tissue in vivo, said method comprising contacting said cell or tissue with an antisense oligonucleotide 12 to 30 nucleobases in length targeted to SEQ ID NO:

  • 4, wherein said antisense oligonucleotide comprises at least 8 consecutive nucleobases of SEQ ID NO;

    23 and is 100% complementary to SEQ ID NO;

    4, thereby inhibiting the expression of apolipoprotein(a).

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