Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
First Claim
1. A spinning disk apparatus for producing microparticles comprising a substantially circular spinning disk, wherein the spinning disk comprises:
- (A) an inner peripheral edge;
(B) an outer peripheral edge;
(C) a substantially smooth annular disk surface extending between the inner peripheral edge and the outer peripheral edge, wherein(i) the outer peripheral edge defines a first diameter of the annular disk surface,(ii) the annular disk surface has a second diameter defined by the area circumscribed by the inner peripheral edge, wherein the area circumscribed by the inner peripheral edge is disposed substantially in a center portion of the spinning disk, and(iii) the annular disk surface extending between the inner peripheral edge and the outer peripheral edge comprises a substantially flat incline; and
(D) a reservoir disposed in the area circumscribed by the inner peripheral edge of the annular disk surface, wherein(i) the reservoir comprises a top portion thereof defined by the second diameter, and(ii) the reservoir comprises a cross-sectional area defined by a third diameter, located between the bottom of the reservoir and the top portion of the reservoir, wherein the third diameter is greater than the second diameter.
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Accused Products
Abstract
This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.
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Citations
23 Claims
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1. A spinning disk apparatus for producing microparticles comprising a substantially circular spinning disk, wherein the spinning disk comprises:
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(A) an inner peripheral edge; (B) an outer peripheral edge; (C) a substantially smooth annular disk surface extending between the inner peripheral edge and the outer peripheral edge, wherein (i) the outer peripheral edge defines a first diameter of the annular disk surface, (ii) the annular disk surface has a second diameter defined by the area circumscribed by the inner peripheral edge, wherein the area circumscribed by the inner peripheral edge is disposed substantially in a center portion of the spinning disk, and (iii) the annular disk surface extending between the inner peripheral edge and the outer peripheral edge comprises a substantially flat incline; and (D) a reservoir disposed in the area circumscribed by the inner peripheral edge of the annular disk surface, wherein (i) the reservoir comprises a top portion thereof defined by the second diameter, and (ii) the reservoir comprises a cross-sectional area defined by a third diameter, located between the bottom of the reservoir and the top portion of the reservoir, wherein the third diameter is greater than the second diameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification