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Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents

  • US 7,261,529 B2
  • Filed: 09/07/2005
  • Issued: 08/28/2007
  • Est. Priority Date: 09/07/2005
  • Status: Active Grant
First Claim
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1. A spinning disk apparatus for producing microparticles comprising a substantially circular spinning disk, wherein the spinning disk comprises:

  • (A) an inner peripheral edge;

    (B) an outer peripheral edge;

    (C) a substantially smooth annular disk surface extending between the inner peripheral edge and the outer peripheral edge, wherein(i) the outer peripheral edge defines a first diameter of the annular disk surface,(ii) the annular disk surface has a second diameter defined by the area circumscribed by the inner peripheral edge, wherein the area circumscribed by the inner peripheral edge is disposed substantially in a center portion of the spinning disk, and(iii) the annular disk surface extending between the inner peripheral edge and the outer peripheral edge comprises a substantially flat incline; and

    (D) a reservoir disposed in the area circumscribed by the inner peripheral edge of the annular disk surface, wherein(i) the reservoir comprises a top portion thereof defined by the second diameter, and(ii) the reservoir comprises a cross-sectional area defined by a third diameter, located between the bottom of the reservoir and the top portion of the reservoir, wherein the third diameter is greater than the second diameter.

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