Forward scanning imaging optical fiber probe

• US 7,261,687 B2
• Filed: 03/22/2005
• Issued: 08/28/2007
• Est. Priority Date: 03/23/2004
• Status: Expired due to Fees

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Yang, Changhuei
• Primary Examiner(s): Leubecker; John P
• Application Number:
  US11/087,396
• Publication Number:
  US 20050234345A1
• Time in Patent Office: 889 Days
• Field of Search: 600/182, 600/173, 600/176, 600/137, 600/473, 600/478, 385/116, 385/117, 385/119, 359/837, 356/455
• US Class Current: 600/173
• CPC Class Codes: A61B 1/00096 Optical elements
• CPC Class Codes: A61B 1/00172 with means for scanning
• CPC Class Codes: A61B 1/00183 for variable viewing angles
• CPC Class Codes: A61B 1/07 using light-conductive means, e.g. optical fibres
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/6852 Catheters

Abstract

Probes, and systems and methods for optically scanning a conical volume in front of a probe, for use with an imaging modality, such as Optical Coherence Tomography (OCT). A probe includes an optical fiber having a proximal end and a distal end and defining an axis, with the proximal end of the optical fiber being proximate a light source, and the distal end having a first angled surface. A refractive lens element is positioned proximate the distal end of the optical fiber. The lens element and the fiber end are both configured to separately rotate about the axis so as to image a conical scan volume when light is provided by the source. Reflected light from a sample under investigation is collected by the fiber and analyzed by an imaging system. Such probes may be very compact, e.g., having a diameter 1 mm or less, and are advantageous for use in minimally invasive surgical procedures.

Claims

1. An optical apparatus, comprising:

an optical fiber including a proximal end and a distal end and defining an axis, wherein the proximal end of the optical fiber is proximate a light source, and wherein the distal end comprises a first angled surface; and

a refractive lens element proximate the distal end of the optical fiber, wherein the lens element and the optical fiber are both configured to rotate about said axis, and wherein the optical fiber and the lens are configured to rotate relative to each other about said axis;

a motor adapted to cause the optical fiber to rotate about said axis; and

a coupling mechanism that couples the motor to the lens element such that the motor also causes the lens element to rotate about said axis, wherein the coupling mechanism is adapted to rotate the lens element about said axis at a different rate than a rate of rotation of the optical fiber about said axis.

2. The optical apparatus of claim 1, wherein the lens element includes a second angled surface that is substantially complementary to the first angled surface of the optical fiber when the lens element is in a first rotational orientation about said axis.

3. The optical apparatus of claim 1, wherein the lens element includes a GRIN lens.

4. The optical apparatus of claim 3, wherein the lens element includes an optical wedge element attached to an end face of the GRIN lens.

5. The optical apparatus of claim 1, wherein the coupling mechanism includes a ratchet and pawl type coupler.

6. The optical apparatus of claim 1, wherein the optical apparatus is an optical coherence microscope probe.

7. The apparatus of claim 1, wherein the distal end of the fiber includes a GRIN lens that is angled cut at an angle relative to a plane normal to said axis.

8. The apparatus of claim 1, wherein the distal end of the fiber includes a GRIN lens and an optical wedge element attached to an end face of the GRIN lens.

9. An optical apparatus, comprising:

an optical fiber including a proximal end and a distal end and defining an axis, wherein the proximal end of the optical fiber is proximate a light source, and wherein the distal end is proximal a first refractive lens element; and

a second refractive lens element proximate the first lens element, wherein the second lens element is configured to rotate about said axis, and wherein the first lens element is configured to rotate about said axis separate from the second lens element, and wherein the first lens element rotates at a different rate of rotation than a rate of rotation of the second lens element.

10. The apparatus of claim 9, wherein the first lens element includes a GRIN lens that is angled cut at a first angle relative to a plane normal to said axis.

11. The apparatus of claim 10, wherein the second lens element includes a second GRIN lens that is angled cut at a second angle relative to the plane normal to said axis, said second angle being substantially the same as the first angle.

12. The apparatus of claim 10, wherein the second lens element includes a second GRIN lens and a second optical wedge element attached thereto, said second wedge element providing an end face at a second angle relative to a plane normal to said axis, said second angle being substantially the same as the first angle.

13. The apparatus of claim 9, wherein the first lens element includes a GRIN lens and an optical wedge element attached thereto, said wedge element providing an end face at a first angle relative to a plane normal to said axis.

14. The apparatus of claim 9, comprising a first motor coupled with the fiber, and a second motor coupled with the second lens element, wherein the first motor is configured to rotate the first lens element about said axis, and wherein the second motor is configured to rotate the second lens element about said axis in a different or same rotational direction as the first lens element.

15. A method of imaging a forward scan volume of a tissue sample using a forward scanning probe that includes an optical fiber including a proximal end and a distal end and defining an axis, wherein the proximal end of the optical fiber is proximate a light source, and wherein the distal end is proximal a first refractive lens element, wherein the probe further includes an imaging end having a second refractive lens element positioned proximate the first lens element, wherein the second lens element is configured to rotate about the axis, and wherein the first lens element is configured to rotate about the axis separate from the second lens element, the method comprising:

positioning the imaging end of the probe proximal a tissue sample to be imaged;

providing a light beam to the proximal fiber end from the light source;

rotating the first lens element at a first rate; and

simultaneously rotating the second lens element at a second rate different from the first rate.

16. The method of claim 15, wherein light reflected by the tissue sample is collected in the fiber, the method further comprising capturing the reflected light from the tissue sample in the fiber using an optical coherence tomography imaging system.

17. The method of claim 15, wherein the light beam has a wavelength in one of the IR or near-JR wavelength spectrum.

18. The method of claim 15, wherein each of the first lens element and second lens element is rotated at between approximately 1 Hz and approximately 1 kHz.

19. The method of claim 18, wherein the first lens element is rotated at approximately 100 Hz and wherein the second lens element is rotated at approximately 1 Hz.

20. An optical apparatus, comprising:

an optical fiber including a proximal end and a distal end and defining an axis, wherein the proximal end of the optical fiber is proximate a light source, and wherein the distal end comprises a first angled surface; and

a refractive lens element proximate the distal end of the optical fiber, wherein the lens element and the optical fiber are both configured to rotate about said axis, and wherein the optical fiber and the lens are configured to rotate relative to each other about said axis;

a first motor adapted to cause the optical fiber to rotate about said axis; and

a second motor adapted to cause the lens element to rotate about said axis in a different or same rotational direction as the optical fiber,

wherein the second motor rotates the lens element about said axis at a different rate than a rate of rotation of the optical fiber about said axis.