Hemostasis analyzer and method

• US 7,261,861 B2
• Filed: 04/24/2003
• Issued: 08/28/2007
• Est. Priority Date: 04/24/2003
• Status: Active Grant

• Current Assignee: Haemonetics Corporation
• Original Assignee: Haemoscope Corp. (Haemonetics Corporation)
• Inventors: Kautzky, Hans
• Primary Examiner(s): Warden; Jill
• Assistant Examiner(s): HYUN, PAUL SANG HWA
• Application Number:
  US10/422,229
• Publication Number:
  US 20040214337A1
• Time in Patent Office: 1,587 Days
• Field of Search: 73/644.1, 422/73, 436/69
• US Class Current: 422/73
• CPC Class Codes: B01L 2300/024 Storing results with means integrated into the container
• CPC Class Codes: B01L 2300/0663 Whole sensors
• CPC Class Codes: B01L 2300/0809 rectangular shaped
• CPC Class Codes: B01L 3/508 rigid containers not provided for above
• CPC Class Codes: G01N 33/4905 Determining clotting time of blood by chemical methods G01N33/86, C12Q1/56

Abstract

A method and device for blood hemostasis analysis is disclosed. A blood sample is displaced to reach a resonant state. The resonant frequency of the blood sample is determined before, during and after a hemostasis process. The changes in the resonant frequency of the blood sample are indicative of the hemostasis characteristics of the blood sample.

Claims

1. An apparatus for measuring hemostasis comprising:

a. a container adapted to hold a blood sample, the container including a portion transparent to an emission from a sensor;

b. a shaker adapted to displace the container in order to cause a resonant excitation of the blood sample, the blood sample being excited to a resonant state; and

c. the sensor adapted to determine a movement of the blood sample corresponding to the resonant excitation of the blood sample within the container responsive to the displacement of the container by the shaker by generating the emission and directing the emission toward the blood sample through the portion;

d. wherein data from the sensor is indicative of the resonant state of the blood sample and the shaker is configured to displace the container at a displacement frequency and configured to vary the displacement frequency responsive to changes in the resonant state of the blood sample.

2. An apparatus according to claim 1, further comprising an analyzer coupled to the sensor to receive the data from the sensor, the analyzer being adapted to derive a hemostasis characteristic of the blood sample based upon the data from the sensor.

3. An apparatus according to claim 1, wherein the shaker is configured to displace the container with a white noise frequency function.

4. An apparatus according to claim 1, wherein the container includes a self-sealing port for receiving the blood sample.

5. An apparatus according to claim 1, wherein the container is a sealed container.

6. An apparatus according to claim 1, wherein the container is safely disposable.

7. An apparatus according to claim 1, wherein the container comprises a first portion connected to a larger second portion, wherein the blood sample fills the first portion.

8. An apparatus according to claim 1, wherein the sensor is an optical sensor.

9. An apparatus for measuring hemostasis comprising:

a. a slot for receiving a container having therein a blood sample, wherein a portion of the container is transparent to an emission from a sensor;

b. a shaker adapted to displace the container in order to cause an excitation of the blood sample, the blood sample being excited to a resonant state;

c. the sensor adapted to determine a movement of the blood sample within the container responsive to the displacement of the container by the shaker by generating the emission and directing the emission toward the blood sample through the portion; and

d. an analyzer coupled to the sensor to receive data from the sensor, the analyzer being adapted to derive a hemostasis characteristic of the blood sample based upon the data from the sensor;

e. wherein data from the sensor is indicative of the resonant state of the blood sample and the shaker is configured to displace the container at a displacement frequency and configured to vary the displacement frequency responsive to changes in the resonant state of the blood sample.

10. An apparatus according to claim 9, wherein the shaker is configured to displace the container with a white noise frequency function.