Phospholipase C inhibitors for use in treating inflammatory disorders

• US 7,262,197 B2
• Filed: 03/31/2004
• Issued: 08/28/2007
• Est. Priority Date: 03/31/2003
• Status: Expired due to Fees

• Current Assignee: Janssen Pharmaceutica NV (Johnson & Johnson)
• Original Assignee: Janssen Pharmaceutica NV (Johnson & Johnson)
• Inventors: Lagu, Bharat, Wachter, Michael, Rupert, Kenneth
• Primary Examiner(s): BERNHARDT, EMILY B
• Application Number:
  US10/815,048
• Publication Number:
  US 20040235827A1
• Time in Patent Office: 1,245 Days
• Field of Search: 544/357, 544/379
• US Class Current: 514/252.11
• CPC Class Codes: C07D 295/135 with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
• CPC Class Codes: C07D 295/192 from aromatic carboxylic acids
• CPC Class Codes: C07D 307/68 Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

This invention is directed to heterocyclyl-substituted anilino phospholipase C inhibitor compounds useful in treating or ameliorating an inflammatory disorders and/or restenosis of the general formula (I):

and enantiomers, diastereomers and pharmaceutically acceptable salts thereof. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions affected by phospholipase modulation.

Claims

1. A compound selected from the group consisting of:

N-[2-[4-(diphenylmethyl)-1-piperazinyl]-5-(1-piperazinylcarbonyl)phenyl]-4-methyl-benzamide;

5-(4-chlorophenyl)-N-[2-[4-(diphenylmethyl)-1-piperazinyl]-5-(1-piperazinylcarbonyl)phenyl]-2-methyl-3-furancarboxamide;

N-[2-[4-(diphenylmethyl)-1-piperazinyl]-5-(1-piperazinylcarbonyl)phenyl]-2-furancarboxamide; and

N-[2-[4-(diphenylmethyl)-1-piperazinyl]-5-(1-piperazinylcarbonyl)phenyl]-propanamide.

2. A composition comprising a pharmaceutically acceptable carrier, excipient, tableting ingredient or diluent and the compound of claim 1.