Synergistic mixtures of o-phenylphenol and other nitrogen and aldehyde microbiocides

• US 7,262,222 B2
• Filed: 01/16/2003
• Issued: 08/28/2007
• Est. Priority Date: 01/17/2002
• Status: Active Grant

• Current Assignee: Lanxess Corporation (Lanxess AG)
• Original Assignee: Verichem, Inc. (Lanxess AG)
• Inventors: Carlson, Paul E., Nehus, H. Edwin
• Primary Examiner(s): PAK, JOHN D
• Application Number:
  US10/345,797
• Publication Number:
  US 20030196968A1
• Time in Patent Office: 1,685 Days
• Field of Search: 514/634, 514/565, 514/736, 210/764
• US Class Current: 514/634
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/17 having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64
• CPC Class Codes: A61K 31/41 having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
• CPC Class Codes: A61K 31/53 having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine melarsoprol A61K31/555 ; with four nitrogen atoms A61K31/495
• CPC Class Codes: C02F 1/50 by addition or application of a germicide or by oligodynamic treatment C02F1/4606, C02F1/467, C02F1/76 take precedence
• CPC Class Codes: C02F 2103/023 Water in cooling circuits

Abstract

Ortho phenylphenol or its sodium salt is shown to form synergistic antimicrobial mixtures with nitrogen and aldehyde-containing microbiocides.

Claims

1. An antimicrobial synergistic mixture of orthophenylphenol or its sodium salt and dodecyl guanidine hydrochloride wherein the mixture is determined to be antimicrobial synergistic by having a synergy index of less than 1 in a white water at pH about 5.5.

2. The mixture of claim 1 in a weight radio of dodecyl guanidine hydrochloride to orthophenylphenol or its sodium salt from 1-160 to 1-800.

3. A method of controlling microorganisms in industrial water system comprising:

a) providing an industrial water system; and

b) adding an antimicrobial mixture of orthophenylphenol or its sodium salt and dodecyl guanidine hydrochloride to the industrial water system, wherein the mixture is determined to be antimicrobial synergistic by having a synergy index of less than 1 in a white water at pH about 5.5.

4. The method of claim 3 wherein the weight ratio of dodecyl guanidine hydrochloride to orthophenylphenol or its sodium salt is about 1:

160 to 1;

800.

5. A mixture of dodecyl guanidine hydrochloride and orthophenylphenol or its sodium salt in a ratio of about 1:

793.7 that shows antimicrobial synergism when in a industrial water system having a pH of about 5.5.

6. A method of controlling microorganisms in industrial water systems comprising:

a) providing an industrial water system; and

b) adding a mixture of dodecyl guanidine hydrochloride and orthophenylphenol or its sodium salt in a ratio of about 1;

793.7.