Pyrrolobenzodiazepines

• US 7,265,105 B2
• Filed: 03/02/2006
• Issued: 09/04/2007
• Est. Priority Date: 08/27/1998
• Status: Expired due to Term

• Current Assignee: MedImmune Ltd. (Astrazeneca PLC)
• Original Assignee: Spirogen Limited
• Inventors: Howard, Philip Wilson, Thurston, David Edwin
• Primary Examiner(s): COLEMAN, BRENDA LIBBY
• Application Number:
  US11/367,241
• Publication Number:
  US 20060148788A1
• Time in Patent Office: 551 Days
• Field of Search: 514/220, 540/496
• US Class Current: 514/220
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 33/00 Antiparasitic agents
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07D 487/04 Ortho-condensed systems

Abstract

A compound of the formula II:

wherein:

• • R′₂ is CHR″₂, where R″₂ is H.
  • R₆ and R₉ are H and R₇ is OMe
  • and the compound is a dimer with each monomer being the same and being of formula II, where the R₈ groups of the monomers form together a bridge having the formula —O—(CH₂)_p—O—, where p is 5, linking the monomers.

Claims

1. A compound of the formula:

2. A method of treating cancer of the human or animal body comprising administering to such a subject a therapeutically effective amount of a compound according to claim 1, wherein the cancer is selected from the group consisting of lung cancer, colon cancer, ONS cancer, melanoma, breast cancer, and ovarian cancer.

3. A method of treatment of a bacterial infection of the human or animal body comprising administering to such a subject a therapeutically effective amount of a compound according to claim 1.