Multi-frequency microwave-induced thermoacoustic imaging of biological tissue

• US 7,266,407 B2
• Filed: 11/17/2003
• Issued: 09/04/2007
• Est. Priority Date: 11/17/2003
• Status: Expired due to Fees

• Current Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Original Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Inventors: Li, Jian, Wang, Gang
• Primary Examiner(s): Casler; Brian L.
• Assistant Examiner(s): RAMIREZ, JOHN FERNANDO
• Application Number:
  US10/714,795
• Publication Number:
  US 20050107692A1
• Time in Patent Office: 1,387 Days
• Field of Search: 600/430
• US Class Current: 600/430
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence

Abstract

A method and system for examining biological tissue includes the steps of radiating a tissue region with a plurality of microwave radiation pulses. The microwave pulses are swept across a range of microwave frequencies. In response to the swept frequency microwave pulses, the tissue region emits a plurality of thermoacoustic signals. At least one image of the tissue region is formed from the plurality of thermoacoustic signals. The signals can be ultrawideband signals.

Claims

1. A method of examining biological tissue, comprising the steps of:

radiating a tissue region with a plurality of microwave radiation pulses, said plurality of radiation pulses spanning a range of microwave frequencies of at least 600 MHz, wherein said tissue region emits a plurality of thermoacoustic signals responsive to said plurality of microwave pulses, and

forming at least one image of said tissue region from said plurality of thermoacoustic signals,

wherein said step of forming at least one image comprises adaptive beamforming.

2. The method of claim 1 wherein said tissue region comprises breast tissue.

3. The method of claim 2, wherein said at least one image of said breast tissue comprises a plurality of said images, said plurality of images from fractional portions of said breast, further comprising the step of combining said images from said local regions to form an overall image of said breast.

4. The method of claim 1, wherein said frequency range is at least 1 GHz.

5. The method of claim 1, wherein said step of forming at least one image comprises adaptive beamforming.

6. The method of claim 5, wherein said adaptive beamforming comprises the steps of:

providing a sensor array including a plurality of sensor elements, wherein an array steering vector corresponding to a signal of interest (SOI) is unknown;

representing said array steering vector with an ellipsoidal uncertainty set;

bounding a covariance fining relation for said array steering vector with said uncertainty ellipsoid, and

solving said covariance fitting relation to provide an estimate of said array steering vector.

7. The method of claim 1, wherein said pulses include at plurality of different polarizations.

8. The method of claim 1, further comprising the step of pattern recognition from said image.

9. The method of claim 8, wherein said step of pattern recognition comprises adaptive signal processing.

10. A system for examining biological tissue, comprising:

a microwave radiation source for radiating a tissue region with a plurality of microwave radiation pulses, said plurality of radiation pulses spanning a range of microwave frequencies of at least 600 MHz, wherein said tissue region emits a plurality of thermoacoustic signals responsive to said microwave pulses;

an acoustic transducer array for receiving said thermoacoustic signals, said transducer array providing electrical signals in response thereto, and

an imager comprising a signal processor having an executable adaptive beamforming algorithm,

said algorithm forming at least one image of said tissue region from said electrical signals.

11. The system of claim 10, further comprising at least one horn antenna coupled to said microwave radiation source for emanating said plurality of microwave pulses.

12. The system of claim 11, further comprising structure for translating at least one of said transducer array and said antenna.

13. The system of claim 10, wherein said plurality of radiation pulses span a frequency range of at least 1 GHz.

14. The system of claim 10, wherein said pulses include a plurality of different polarizations.