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Programmable multiplexed active biologic array

  • US 7,267,751 B2
  • Filed: 08/20/2002
  • Issued: 09/11/2007
  • Est. Priority Date: 08/20/2002
  • Status: Expired due to Term
First Claim
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1. A digitally programmable array-based electronic chip for carrying out biological reactions in response to electrical stimuli, comprising:

  • an array of electrode sites, each electrode site including a sample-and-hold circuit coupled to a working electrode;

    a plurality of switches for selectively coupling the working electrodes to the output of a digital-to-analog converter (DAC);

    a control logic module coupled to the DAC and the plurality of switches;

    a measurement circuit comprising one or more electrical output pathways for selectively coupling the array of electrode sites to an analog-to-digital converter (ADC), the ADC coupled to the control logic module;

    a current measurement circuit, the current measurement circuit comprising a first selectable connection to the sample-and-hold circuit, a series connected resistor and a second selectable connection to the sample-and-hold circuit, the current measurement circuit operating in a current measurement mode when the first and second selectable connections are closed and in a high impedance mode when the first and second selectable connections are open; and

    an external processor that digitally interfaces with the control logic module, wherein the communication between the control logic and the external processor includes a clock signal, a data in signal, and a data out signal.

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