Repetitive visual stimulation to EEG neurofeedback protocols

• US 7,269,456 B2
• Filed: 05/30/2002
• Issued: 09/11/2007
• Est. Priority Date: 05/30/2002
• Status: Active Grant

• Current Assignee: Thomas F. Collura
• Original Assignee: Thomas F. Collura
• Inventors: Collura, Thomas F.
• Primary Examiner(s): Marmor, II; Charles A.
• Assistant Examiner(s): Natnithithadha; Navin
• Application Number:
  US10/158,299
• Publication Number:
  US 20030225340A1
• Time in Patent Office: 1,930 Days
• Field of Search: 600/545, 600/544, 128/905
• US Class Current: 600/545
• CPC Class Codes: A61B 5/375 using biofeedback
• CPC Class Codes: A61B 5/378 Visual stimuli
• CPC Class Codes: A61B 5/38 Acoustic or auditory stimuli
• CPC Class Codes: Y10S 128/905 Feedback to patient of biological signal other than brain electric signal

Abstract

An EEG neurofeedback and total evoked brain activity measurement methods utilize minimum ambient EEG activity as stimulant frequencies. A method of using repetitive stimulation in conjunction with EEG neurofeedback protocols is described. Electrodes, attached to a subject'"'"'s scalp, transmit electroencephalographic (EEG) signals from the subject. These signals are in response to the visual and/or auditory stimuli being displayed to the subject. The resultant EEG signals are then filtered at pre-defined frequencies or frequency bands. The output from the filtered EEG signals is then analyzed and monitored for short-term state changes. The invention also uses flicker stimulation, real-time signal filtration and feedback, feedback during audio and visual stimulation derived from filtered outputs, and fundamental and integral harmonics in combination with total evoked response.

Claims

1. A method of measuring sensory and perceptual mechanisms of the brain, and training these mechanisms with feedback, comprising the steps of:

securing electrodes to a subject'"'"'s scalp;

displaying stimuli to the subject;

receiving an electroencephalographic (EEG) signal from the subject while the stimuli is being displayed;

transmitting the resultant EEG signal to a filter;

narrow band filtering the EEG signal to a predefined frequency;

reconstructing the total evoked brain activity by combining the filter outputs;

feeding back in real-time of the total evoked response comprising at least one steady-state visual evoked potential (SSVEP) component amplitude; and

monitoring, in real-time, the short-term changes in each of the SSVEP component amplitudes, for the interpretation of waxing and waning behavior to reflect variations in sensory and perceptual vigilance for use as criteria for providing feedback for at least one of training, monitoring, and assessment purposes.

2. The method of claim 1 wherein the EEG signal is used to control a stimulator which produces a visual stimulus, wherein the control trains an increase or decrease in the evoked response.

3. The method of claim 1 wherein auditory feedback consisting of heard sounds is employed to reflect to the subject the subject'"'"'s brain response to the applied visual, wherein the feedback trains the sensory/perceptual pathways of the brain.

4. The method of claim 1 wherein the subject receives, in real-time feedback specific to particular sensory and perceptual pathways of the brain, and receives feedback, of evoked-potential components that differentially reflect waxing and waning of independent generators in the brain, with real-time information facilitating operant or learned (volitional) conditioning of the brain.

5. The method of claim 1 wherein particular components of the SSVEP are extracted in real-time and used to make a control decision that can result in either a change in feedback, an automated decision, a switch closure, the triggering of an actuator, or another event.

6. The method of claim 1 wherein the composition of harmonic activity in the SSVEP is used in real-time to provide variations in an auditory feedback signal, so that the trainee hear, separately, the brain'"'"'s visual primary and secondary sensory and perceptual response mechanisms in real time via an audio amplifier for training purposes.

7. A method of measuring sensory and perceptual mechanisms of the brain, either separately or together, and training these mechanisms with feedback, comprising the steps of:

securing electrodes to a subject'"'"'s scalp;

displaying stimuli to the subject;

receiving an electroencephalographic (EEG) signal from the subject while the stimuli is being displayed;

transmitting the resultant EEG signal to a filter;

narrow band filtering the EEG signal to a predefined frequency;

reconstructing the total evoked brain activity by combining the filtered waveform outputs;

feeding back in real-time of the total evoked response comprising a steady-state visual evoked potential (SSVEP) waveform; and

reconstructing, in real-time, an estimate of the SSVEP waveform using the combined filtered waveform outputs for dynamically tracking latency and amplitude for the measurement of sensory and perceptual mechanisms of the brain.

8. The method of claim 7 wherein the EEG signal is used to control a stimulator which produces a visual stimulus, wherein the control trains an increase or decrease in the evoked response.

9. The method of claim 7 wherein auditory feedback consisting of heard sounds is employed to reflect to the subject the subject'"'"'s brain response to the applied visual, wherein the feedback trains the sensory/perceptual pathways of the brain.

10. The method of claim 7 wherein the subject receives, in real-time feedback specific to particular sensory and perceptual pathways of the brain, and receives feedback, of evoked-potential components that differentially reflect waxing and waning of independent generators in the brain, with real-time information facilitating operant or learned (volitional) conditioning of the brain.

11. The method of claim 7 wherein particular components of the SSVEP are extracted in real-time and used to make a control decision that can result in either a change in feedback, an automated decision, a switch closure, the triggering of an actuator, or another event.

12. The method of claim 7 wherein the composition of harmonic activity in the SSVEP is used in real-time to provide variations in an auditory feedback signal, so that the trainee hears, separately, the brain'"'"'s visual primary and secondary sensory and perceptual response mechanisms in real time via an audio amplifier for training purposes.