Method and system for vagal nerve stimulation with multi-site cardiac pacing
First Claim
Patent Images
1. A method of performing a medical procedure, comprising:
- positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue, wherein the first stimulation electrode is positioned through a percutaneous incision;
positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue;
positioning a third stimulation electrode in a third position to stimulate a nerve;
providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract;
providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and
providing stimulation energy to the third stimulation electrode to stimulate the nerve.
1 Assignment
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Accused Products
Abstract
A method of performing a medical procedure is provided. The medical procedure includes stimulation of a patient'"'"'s heart while stimulating a nerve of the patient in order to modulate the patient'"'"'s inflammatory process. More particularly, the medical procedure includes pacing the ventricles of the patient'"'"'s heart while stimulating the vagal nerve of the patient. Systems and devices for performing the medical procedure are also provided.
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Citations
86 Claims
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1. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue, wherein the first stimulation electrode is positioned through a percutaneous incision; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve, wherein the step of providing stimulation energy to the third stimulation electrode is coordinated with steps of providing stimulation energy to the first and second stimulation electrodes, and wherein the nerve is stimulated while stopping stimulation of the first and second portions of cardiac tissue.
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20. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve, wherein the step of providing stimulation energy to the third stimulation electrode is coordinated with steps of providing stimulation energy to the first and second stimulation electrodes, and wherein the first and second portions of cardiac tissue are stimulated while stopping stimulation of the nerve. - View Dependent Claims (21)
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22. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; providing stimulation energy to the third stimulation electrode to stimulate the nerve; and delivering at least one drug during the medical procedure.
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23. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue, wherein the first stimulation electrode is positioned through a thoracotomy; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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24. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue, wherein the first stimulation electrode is positioned through a sternotomy; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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25. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue, wherein the first position is an epicardial position; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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26. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue, wherein the first position is a myocardial position; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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27. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue, wherein the first position is a venous position; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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28. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue, wherein the first position is an arterial position; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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29. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue, wherein the second stimulation electrode is positioned through a thoracotomy; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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30. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue, wherein the second stimulation electrode is positioned through a sternotomy; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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31. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue, wherein the second stimulation electrode is positioned through a percutaneous incision; positioning a third stimulation electrode in a third position to stimulate a nerve;
providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract;providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39)
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40. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue, wherein the second position is an epicardial position; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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41. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue, wherein the second position is a myocardial position; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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42. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue, wherein the second position is a venous position; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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43. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue, wherein the second position is an arterial position; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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44. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve, wherein the third stimulation electrode is positioned through a thoracotomy; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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45. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve, wherein the third stimulation electrode is positioned through a sternotomy; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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46. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve, wherein the third stimulation electrode is positioned through a percutaneous incision; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve. - View Dependent Claims (47, 48, 49, 50)
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51. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve, wherein the third position is a venous position; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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52. 1he A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve, wherein the third position is an arterial position; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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53. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve, wherein the third position is an esophageal position; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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54. The A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve, wherein the third position is a tracheal position; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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55. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve, wherein the third position is a cutaneous position; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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56. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue, wherein a cardiac stimulator provides the stimulation energy to the first and second stimulation electrodes and wherein the cardiac stimulator is an external cardiac stimulator; and providing stimulation energy to the third stimulation electrode to stimulate the nerve.
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57. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; and providing stimulation energy to the third stimulation electrode to stimulate the nerve, wherein a nerve stimulator provides the stimulation energy to the third stimulation electrode and wherein the nerve stimulator is an external nerve stimulator.
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58. A method of performing a medical procedure, comprising:
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positioning a first stimulation electrode in a first position to stimulate a first portion of cardiac tissue; positioning a second stimulation electrode in a second position to stimulate a second portion of cardiac tissue; positioning a third stimulation electrode in a third position to stimulate a nerve; providing stimulation energy to the first stimulation electrode to stimulate the first portion of cardiac tissue to contract; providing stimulation energy to the second stimulation electrode to stimulate the second portion of cardiac tissue to contract in synchrony with the first portion of cardiac tissue; providing stimulation energy to the third stimulation electrode to stimulate the nerve; and a sensor to detect an inflammatory agent. - View Dependent Claims (59)
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60. A method of performing a medical procedure, comprising:
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providing stimulation energy from a cardiac stimulator to a first stimulation electrode to stimulate a first portion of cardiac tissue; providing stimulation energy from the cardiac stimulator to a second stimulation electrode to simultaneously stimulate a second portion of cardiac tissue; and providing stimulation energy from a nerve stimulator to a third stimulation electrode to stimulate a vagal nerve. - View Dependent Claims (61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73)
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74. A system for performing a medical procedure, comprising:
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an implantable nerve stimulator for delivering stimulation energy to one or more nerve stimulation electrodes; an implantable cardiac stimulator in communication with the nerve stimulator for delivering stimulation energy to two or more stimulation electrodes; and one or more sensors in communication with the nerve stimulator. - View Dependent Claims (75, 76, 77)
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78. A system for performing a medical procedure, comprising:
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an implantable nerve stimulator for delivering stimulation energy to one or more nerve stimulation electrodes; an implantable cardiac stimulator in communication with the nerve stimulator for delivering stimulation energy to two or more stimulation electrodes; and one or more sensors in communication with the nerve stimulator and the cardiac stimulator.
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79. A device for performing a medical procedure comprising:
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a processor; one or more nerve stimulation electrodes operatively connected to the processor; two or more cardiac stimulation electrodes operatively connected to the processor; and one or more physician operated switches operatively connected to the processor to allow a physician to regulate stimulation output from the one or more nerve stimulation electrodes and the two or more cardiac stimulation electrodes. - View Dependent Claims (80, 81, 82, 83, 84, 85, 86)
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Specification