Medicament respiratory delivery device

• US 7,270,127 B2
• Filed: 09/03/2002
• Issued: 09/18/2007
• Est. Priority Date: 01/12/2001
• Status: Expired due to Term

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Sullivan, Vincent J., Wills, Anjana Bhuta, Monahan, Lawrence A., Lockhart, Artis R.
• Primary Examiner(s): Ho; (Jackie) Tan-Uyen
• Assistant Examiner(s): Erezo; Darwin P.
• Application Number:
  US10/233,863
• Publication Number:
  US 20030047184A1
• Time in Patent Office: 1,841 Days
• Field of Search: 128/200.14, 128/200.23, 128/203.12, 128/203.15, 128/203.21, 128/203.23
• US Class Current: 128/203.15
• CPC Class Codes: A61M 11/003 by passing the aerosol trough sieves or filters
• CPC Class Codes: A61M 11/008 by squeezing, e.g. using a flexible bottle or a bulb
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/003 using capsules, e.g. to be perforated or broken-up
• CPC Class Codes: A61M 15/0031 by bursting or breaking the package, i.e. without cutting or piercing
• CPC Class Codes: A61M 15/0033 Details of the piercing or cutting means
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/073 Syringe, piston type
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: B05B 11/061 characterised by the means producing the gas or vapour pressure
• CPC Class Codes: B05B 11/062 designed for spraying particulate material

Abstract

A medicament respiratory delivery device including a housing formed of opposed thermoformed polymeric sheets bonded together having formed therebetween a chamber having a medicament cartridge encapsulated between the sheets, an inlet aligned with a passage through the cartridge having a pierceable closure and an outlet aligned with the passage outlet having a burstable membrane. The device includes a pressure actuator formed as a blister between the sheets and a piercing element having a bow-shaped actuator portion and a shaft which pierces the pierceable closure upon actuation of the pressure actuator, delivering fluid under pressure to the cartridge passage, rupturing the membrane and expressing the medicament.

Claims

1. A method for delivering a medicament to the respiratory system of a user, comprising:

providing a medicament respiratory delivery device having a chamber with a dry powder medicament contained therein and a pierceable closure sealing the chamber, a compressible pressure actuator in fluid communication with the chamber and having a liquid contained in the pressure actuator, and a piercing element having a pointed end movable relative to said chamber to pierce said pierceable closure, wherein said pressure actuator is a flexible collapsible element and at least a portion of said piercing element is located within said flexible collapsible element;

compressing the pressure actuator;

piercing the pierceable closure;

reconstituting the dry powder medicament with the liquid; and

expelling the reconstituted medicament from the medicament respiratory delivery device.

2. The method of claim 1, wherein the liquid is a diluent.

3. The method of claim 2, wherein reconstituting the dry powder medicament with the liquid and expelling the reconstituted medicament from the medicament respiratory delivery device take place substantially simultaneously.

4. The method of claim 1 wherein said medicament respiratory delivery device further comprises a guiding portion located adjacent to said chamber for receiving said pointed end, wherein said guiding portion guides said pointed end of said piercing element to pierce said pierceable closure upon movement of said piercing element.

5. The method of claim 1 wherein said piercing element includes a shaft wherein said pointed end is at a first end of the shaft.

6. The method of claim 5 wherein said piercing element includes a bow-shaped portion located within said pressure actuator connected to said shaft.

7. The method of claim 6 wherein said medicament respiratory delivery device further comprises a guiding portion located adjacent to said chamber for receiving said pointed end and at least a portion of said shaft, wherein said guiding portion guides said pointed end of said piercing element to pierce said pierceable closure upon movement of said shaft.

8. The method of claim 5 further comprising:

guiding the piercing element as said pointed end moves toward said piercable closure.

9. The method of claim 8 wherein said piercing element includes a bow-shaped portion located within said pressure actuator connected to said shaft.

10. The method of claim 9 further comprising:

compressing the bow shaped portion of said piercing element, thereby moving said pointed end toward said piercable closure.

11. The method of claim 9 wherein said bow-shaped portion of said piercing element includes a concave portion generally conforming to the shape of said pressure actuator having opposed end portions and concave portions integral with said end portions, and said shaft is connected to said convex portions.

12. The method of claim 11 further comprising:

compressing the concave portion of said piercing element, thereby moving said pointed end toward said piercable closure.

15. The method of claim 1 wherein said medicament deliver device further comprises a cartridge, wherein a body of said cartridge is generally cylindrical and said chamber is formed between a pair of sheets, thus forming said piercable closure at either end of said body of said cartridge.

16. The method of claim 15 further comprising:

inserting said cartridge into said medicament respiratory delivery device.

17. The method of claim 15 further comprising bursting the non-pierced sheet, thereby allowing the reconstituted medicament to be expelled from the device.

18. The method of claim 1 wherein said compressing step includes compressing at least a portion of said piercing element, thereby moving said pointed end toward said piercable closure.

13. The method of claim wherein said medicament deliver device further comprises a cartridge, wherein a body of said cartridge is generally cylindrical and said chamber is formed between a pair of sheets, thus forming said piercable closure at either end of said body of said cartridge.

14. The method of claim 13 further comprising bursting the non-pierced sheet, thereby allowing the reconstituted medicament to be expelled from the device.