System and method for distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device

• US 7,272,436 B2
• Filed: 01/25/2005
• Issued: 09/18/2007
• Est. Priority Date: 01/25/2005
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Benser, Michael, Boileau, Peter, Gill, Jong, Florio, Joseph J., Bharmi, Rupinder, Min, Xiaoyi, Bornzin, Gene A.
• Primary Examiner(s): Layno; Carl
• Assistant Examiner(s): LEE, YUN HAENG NMN
• Application Number:
  US11/043,780
• Publication Number:
  US 20060167518A1
• Time in Patent Office: 966 Days
• Field of Search: 600/508, 600/509, 600/513, 600/516, 600/517, 128/899
• US Class Current: 600/513
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/358 Detecting ST segments
• CPC Class Codes: A61B 5/364 Detecting abnormal ECG interval, e.g. extrasystoles, ectopic heartbeats
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/3925 Monitoring; Protecting
• CPC Class Codes: A61N 1/3962 in combination with another heart therapy
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

Claims

1. A method for use with an implantable medical device for detecting hypoglycemia in a patient in which the device is implanted, the method comprising:

tracking QTmax intervals representative of intervals between QRS-complexes and peaks of corresponding T-waves within electrical cardiac signals; and

detecting an episode of hypoglycemia based on a lengthening of the QTmax intervals.

2. The method of claim 1 further comprising tracking QTend intervals representative of intervals between QRS-complexes and ends of corresponding T-waves;

and wherein detection of hypoglycemia is based on a lengthening of both QT max intervals and QTend intervals.

3. The method of claim 1 further comprising tracking patient heart rate and wherein the QTmax intervals are normalized based on heart rate.

4. The method of claim 1 wherein:

tracking QTmax intervals is performed to track baseline intervals based on moving averages; and

detecting an episode of hypoglycemia based on lengthening of the QTmax intervals is performed to detect increases relative to the baseline intervals.

5. The method of claim 4 wherein detecting an episode of hypoglycemia based on lengthening of QTmax intervals is performed based on a plurality of heartbeats.

6. The method of claim 1 further comprising:

tracking elevations of segments of the cardiac signals between depolarization events and corresponding repolarization events; and

confirming detection of an episode of hypoglycemia based on a significant change in elevation of the segments.

7. The method of claim 6 wherein the segment elevations are representative of the elevations of segments of cardiac signals between QRS-complexes and corresponding T-waves.

8. The method of claim 6 wherein:

tracking segment elevations is performed to track a baseline elevation based on a moving average; and

confirming detection of an episode of hypoglycemia based in part on significant changes in the segment elevation is performed to detect a change relative to the baseline elevation.

9. The method of claim 1 further comprising recording diagnostic information representative of the QTmax intervals.

10. The method of claim 1 further comprising controlling therapy in response to the detection of an episode of hypoglycemia.

11. The method of claim 10 wherein an implantable insulin pump is provided and wherein controlling therapy in response to the detection of an episode of hypoglycemia comprises controlling insulin delivery to the patient using the insulin pump.

12. The method of claim 1 further comprising generating a warning signal in response to detection of an episode of hypoglycemia.

13. The method of claim 12 wherein an implantable warning device is provided and wherein generating a warning signal comprises delivering a perceptible warning signal to the patient via the implantable warning device.

14. The method of claim 13 for use with an external warning device and wherein generating a warning signal comprises transmitting control signals to the external warning device for controlling the external device to generate warning signals for warning the patient.

15. A system for use with an implantable medical device for detecting hypoglycemia in a patient in which the device is implanted comprising:

a timing unit configured to track QTmax intervals representative of intervals between QRS-complexes and peaks of corresponding T-waves within electrical cardiac signals; and

a hypoglycemia detection unit configured to detect an episode of hypoglycemia based on a significant increase in the duration of the QTmax intervals.

16. A system for use with an implantable medical device for detecting hypoglycemia in a patient in which the device is implanted comprising:

a timing unit configured to track QTmax values representative of intervals between QRS-complexes and peaks of corresponding T-waves within electrical cardiac signals, to track QTend values representative of intervals between the QRS-complexes and ends of corresponding T-waves, and to track ST segment elevation representative of elevations of segments of the cardiac signals between S-waves and corresponding T-waves; and

a hypoglycemia detection unit configured to detect an episode of hypoglycemia based on a change in ST segment elevation combined with an increase in both QTend and QTmax intervals.

17. A system for use with an implantable medical device for detecting hypoglycemia in a patient in which the device is implanted comprising:

means for tracking QTmax intervals representative of intervals between QRS-complexes and peaks of corresponding T-waves within electrical cardiac signals; and

means for detecting an episode of hypoglycemia based on a lengthening of the QTmax intervals.

18. A method for use with an implantable medical device for detecting hypoglycemia in a patient in which the device is implanted, the method comprising:

tracking QTmax values representative of intervals between QRS-complexes and peaks of corresponding T-waves within electrical cardiac signals, tracking QTend values representative of intervals between the QRS-complexes and ends of corresponding T-waves,

tracking ST segment elevation representative of elevations of segments of the cardiac signals between S-waves and corresponding T-waves; and

detecting an episode of hypoglycemia based on a change in ST segment elevation combined with an increase in both QTend and QTmax intervals.