Intraocular brachytherapy device and method

• US 7,273,445 B2
• Filed: 04/30/2004
• Issued: 09/25/2007
• Est. Priority Date: 04/30/2003
• Status: Active Grant

• Current Assignee: Salutaris Medical Devices, Inc.
• Original Assignee: Board of Trustees of The University of Illinois
• Inventors: Hamilton, Russell J., Walker, Gregory L., Pulido, Jose
• Primary Examiner(s): Lacyk; John P.
• Application Number:
  US10/836,140
• Publication Number:
  US 20050027156A1
• Time in Patent Office: 1,243 Days
• Field of Search: 600 1- 8, 128897-898
• US Class Current: 600/3
• CPC Class Codes: A61N 2005/1025 Wires
• CPC Class Codes: A61N 5/1017 Treatment of the eye, e.g. for "macular degeneration"

Abstract

An ocular brachytherapy device, generally comprising a catheter and wire, impregnated with radioactive material, are provided. The wire is formed having a desired treatment shape and size such that it can be placed near an area requiring treatment and effectuate treatment while not affecting adjacent areas. For ease in placement near such areas the wire is preferably formed using materials having properties that permit formation into a desired shape while allowing the wire to be straightened for retraction into the catheter, the shape returning upon removal from the catheter. The wire is preferably impregnated with radioactive material. When the catheter is placed near the area of treatment and the wire is pushed out of the catheter, the wire retakes the desired form and provides a therapeutic radioactive treatment to the area. Preferably, the radioactive material is placed on one edge of the wire, such that the radiation can be directed to the affected area, and non-affected areas can be shielded from radiation.

Claims

1. An ocular brachytherapy device, comprising:

a catheter for deliver of a radioactive treatment proximal to an affected area selected for treatment;

an elongated wire, having radioactive material on a single edge thereon, the wire being formed from a material having a shape memory and being imparted with a coil spring shape when extended from the catheter, the wire being re-elongated for insertion into the catheter;

the wire and catheter being introduced near the affected area and the wire being pushed out from the catheter such that it reforms the desired shape in the vicinity of the area to be treated;

the wire being placed in the affected area such that the radioactive edge is proximal the area to be treated; and

the catheter further comprises a balloon and means to fill the balloon with a radio opaque material so as to provide shielding, against radiation, when the device is used in ocular brachytherapy.

2. An intraocular brachytherapy device, comprising:

a catheter for delivery of a radioactive treatment proximal to an affected area selected for treatment;

an elongated wire having radioactive material thereon, the radioactive material being on a single edge portion of the wire;

the elongated wire being formed from a material having a shape memory and the wire being imparted with a desired shape;

the wire being disposed, at least in part, in the catheter, such that the portion of the wire in the catheter is made generally straight;

the wire and catheter being introduced near the affected area and the wire being pushed out from the catheter such that it reforms the desired shape in the vicinity of the area to be treated.

3. The intraocular brachytherapy device of claim 2 wherein the wire is imparted with a desired shape selected from the group consisting of:

a spiral, a coil spring shape, a flat spiral.

4. The intraocular brachytherapy device of claim 2 wherein a second portion of the wire, said second portion not having radioactive material thereon, is disposed to shield the radioactive material.

5. The intraocular brachytherapy device of claim 4 wherein the shielding portion of the wire comprises the edge portion of the wire substantially opposing the single edge portion of the wire having radioactive material thereon.

6. The intraocular brachytherapy device of claim 4 wherein the shielding portion of the wire is comprised of an outer portion of a spiral wire shape.

7. The intraocular brachytherapy device of claim 2 wherein said shape presents a substantially hemispherical face to an area to be treated, at least a portion of said hemispherical face including said single edge portion having radioactive material.

8. The intraocular brachytherapy device of claim 2 wherein said wire has a ribbon shape.

9. The intraocular brachytherapy device of claim 2 wherein said wire is tapered.

10. The intraocular brachytherapy device of claim 2 wherein said wire includes a bevel, said bevel comprising a portion of said single edge portion.

11. The intraocular brachytherapy device of claim 2 wherein said single edge portion has varying amounts of radioactive material applied thereto, said amounts of radioactive material varying along the length of said single edge portion.

12. The intraocular brachytherapy device of claim 2 having a plurality of wires, at least one of said wires having the single edge portion having radioactive material thereon.

13. The intraocular brachytherapy device of claim 2 having at least one wire having the single edge portion with the radioactive material thereon and at least one other wire not having radioactive material thereon, said at least one other wire being disposed to shield the radioactive material.

14. The intraocular brachytherapy device of claim 12 wherein said plurality of wires comprises a mesh.

15. The intraocular brachytherapy device of claim 2 further comprising a balloon.

16. The intraocular brachytherapy device of claim 15 wherein said balloon shields the radioactive material.

17. The intraocular brachytherapy device of claim 16 wherein said balloon shields the radioactive material by means of a radio-opaque filler.

18. The intraocular brachytherapy device of claim 16 wherein said balloon shields the radioactive material by means of a radio-opaque surface portion.

19. The intraocular brachytherapy device of claim 12 further comprising a balloon.

20. The intraocular brachytherapy device of claim 2 wherein said radioactive material is selected from the group consisting of:

P-32 and SR-90.

21. The intraocular brachytherapy device of claim 2 wherein said wire is nickel titanium (NiTi).

22. The intraocular brachytherapy device of claim 2 wherein said wire is comprised of nickel titanium (NiTi) and the radioactive material is selected from the group consisting of P-32 and SR-90.

23. The intraocular brachytherapy device of claim 2 wherein the device is constructed with a handle selected from the group consisting of:

a slide mechanism, a dial mechanism, a fitting, and a Toughy-Burst type fitting.

24. The intraocular brachytherapy device of claim 17 wherein the balloon is filled with a solution selected from the group consisting of perfluoroctylbromide, ilhexol and perfluoroctane.

25. The intraocular brachytherapy device of claim 2 wherein said device is dimensioned and arranged for intraocular applications.

26. The intraocular brachytherapy device of claim 2 wherein said device is dimensioned and arranged for a subretinal application.