Device and methods for body fluid flow control in extracorporeal fluid treatments

• US 7,273,465 B2
• Filed: 10/12/2001
• Issued: 09/25/2007
• Est. Priority Date: 10/12/2000
• Status: Expired due to Term

• Current Assignee: Renal Solutions, Inc. (Fresenius Medical Care AG)
• Original Assignee: Renal Solutions, Inc. (Fresenius Medical Care AG)
• Inventors: Ash, Stephen R.
• Primary Examiner(s): Zalukaeva; Tatyana
• Assistant Examiner(s): Deak; Leslie R.
• Application Number:
  US10/399,128
• Publication Number:
  US 20040050789A1
• Time in Patent Office: 2,174 Days
• Field of Search: 604/4.01, 604/5.01, 604/5.04, 604/6.09, 604/6.11, 604 65- 67, 210/645, 210/646, 210/90, 210/739, 210/416.1, 417/118, 417/140, 417/477.1, 417/437, 417/277, 417/274, 417/275, 417/286, 417/297, 417/298, 417/475, 417/521, 417/477.12, 417/395
• US Class Current: 604/6.11
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3663 Flow rate transducers; Flow integrators
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 60/113 in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/37 Haemodialysis, haemofiltration or diafiltration
• CPC Class Codes: A61M 60/43 using vacuum at the blood pump, e.g. to accelerate filling
• CPC Class Codes: A61M 60/435 with diastole or systole switching by valve means located between the blood pump and the hydraulic or pneumatic energy source
• CPC Class Codes: A61M 60/546 of blood flow, e.g. by adapting rotor speed

Abstract

Disclosed are devices and methods for the control of body fluid flow in the extracorporeal treatment of body fluid. Body fluid flow through on of a body fluid flow circuit (10, 50, 60, 100 or 250) is controlled by alternating applying vacuum pressure and positive pressure to the circuit through a pumping chamber (30, 51, 66, 102, or 200) coordinated with flow control valves (40, 42, 44, 62, 114, 116, 118, and 120) to effect a net downstream flow of body fluid through the circuit.

Claims

1. A body fluid treatment apparatus comprising:

a body fluid pumping chamber containing a flexible membrane that is configured to draw body fluid into the pumping chamber under negative gaseous pressure on a gas side of the membrane and alternately to expel body fluid from the pumping chamber under positive gaseous pressure on the gas side of the membrane;

a sensor that is configured to provide a flow rate signal representing a predetermined change in the flow rate of body fluid in flowing into the pumping chamber; and

a control apparatus that is configured to pressurize the pumping chamber on the gas side of the membrane alternately with positive and negative gaseous pressure with reference to the flow rate signal by pressurizing the gas side with negative gaseous pressure and, upon receiving the flow rate signal, switching the pressure at the gas side from negative to positive;

wherein the pumping chamber is one of two body fluid pumping chambers, each of which contains a flexible membrane that is configured to draw body fluid into the respective pumping chamber under negative gaseous pressure on a gas side of the membrane and alternately to expel body fluid from the respective pumping chamber under positive gaseous pressure on the gas side of the membrane, and the control apparatus is configured to pressurize the two pumping chambers alternately with positive and negative gaseous pressure on the gas sides of the membranes to move body fluid through the two pumping chambers in a coordinated relationship that is in phase.

2. An apparatus as defined in claim 1 wherein the two pumping chambers are in parallel.

3. An apparatus as defined in claim 1 wherein the two pumping chambers are in series.

4. An apparatus as defined in claim 1 further comprising a dialyzer and a blood flow circuit, wherein the blood flow circuit is configured to convey blood from a patient to the pumping chambers under the influence of the negative gaseous pressure at the pumping chambers, and to convey blood from the pumping chambers through the dialyzer and back to the patient under the influence of the positive gaseous pressure at the pumping chambers.

5. A body fluid treatment apparatus comprising:

a dialyzer;

a pumping chamber containing a flexible membrane that is configured to draw blood into the pumping chamber under negative gaseous pressure on a gas side of the membrane and alternately to expel blood from the pumping chamber under positive gaseous pressure on the gas side of the membrane;

a blood flow circuit configured to convey blood from a patient to the pumping chamber under the influence of the negative gaseous pressure at the pumping chamber, and to convey blood from the pumping chamber through the dialyzer and back to the patient under the influence of the positive gaseous pressure at the pumping chamber;

a sensor that is configured to provide a flow rate signal representing a blood flow rate in the blood flow circuit; and

a control apparatus that is configured to pressurize the pumping chamber on the gas side of the membrane alternately with positive and negative gaseous pressure with reference to the flow rate signal by pressurizing the gas side with negative gaseous pressure and, upon receiving the flow rate signal, switching the pressure at the gas side from negative to positive;

wherein the pumping chamber is one of two pumping chambers configured to communicate with the patient and the dialyzer through the blood flow circuit, each pumping chamber contains a flexible membrane that is configured to draw blood into the respective pumping chamber under negative gaseous pressure on a gas side of the membrane and alternately to expel blood from the respective pumping chamber under positive gaseous pressure on the gas side of the membrane, and the control apparatus is configured to pressurize the two pumping chambers alternately with positive and negative gaseous pressure on the gas sides of the membranes to move blood through the two pumping chambers in a coordinated relationship that is in phase.

6. An apparatus as defined in claim 5 wherein the two pumping chambers are connected in the blood flow circuit in parallel.

7. An apparatus as defined in claim 5 wherein the two pumping chambers are connected in the blood flow circuit in series.

8. A body fluid treatment apparatus comprising:

a first pumping chamber containing a flexible membrane that is configured to draw blood into the first pumping chamber under negative gaseous pressure on a gas side of the membrane and alternately to expel blood from the first pumping chamber under positive gaseous pressure on the gas side of the membrane;

a second pumping chamber containing a flexible membrane that is configured to draw blood into the second pumping chamber under negative gaseous pressure on a gas side of the membrane and alternately to expel blood from the second pumping chamber under positive gaseous pressure on the gas side of the membrane; and

a control apparatus that is configured to pressurize the first and second pumping chambers alternately with positive and negative gaseous pressure on the gas sides of the membranes in a coordinated relationship that is in phase.

9. An apparatus as defined in claim 8 wherein the first and second pumping chambers are in parallel.

10. An apparatus as defined in claim 8 wherein the first and second pumping chambers are in series.

11. An apparatus as defined in claim 8 further comprising a dialyzer and a blood flow circuit, wherein the blood flow circuit is configured to convey blood from a patient to the pumping chambers under the influence of the negative gaseous pressure at the pumping chambers, and to convey blood from the pumping chambers through the dialyzer and back to the patient under the influence of the positive gaseous pressure at the pumping chambers.