Apparatus and process for conditioning mammalian blood

• US 7,273,586 B2
• Filed: 12/06/2005
• Issued: 09/25/2007
• Est. Priority Date: 09/16/1999
• Status: Expired due to Fees

• Current Assignee: Vasogen Ireland Ltd.
• Original Assignee: Vasogen Ireland Ltd.
• Inventors: Newman, Duncan, Moore, Paul, Muirhead, Allen, Treadwell, Simon, Voakes, Murray, Mongomery, Sonya, Worona, Taras, Chong, Carlton, Porter, Thomas, Liao, Liung Sen, Dayman, Jeff
• Primary Examiner(s): Zalukaeva; Tatyana
• Assistant Examiner(s): Deak; Leslie R.
• Application Number:
  US11/294,443
• Publication Number:
  US 20060084905A1
• Time in Patent Office: 658 Days
• Field of Search: 604/4.01, 604/5.01, 604 608- 614, 604/259, 210/645, 210/739, 210/781, 210/782, 422/99, 422/244, 422/44, 422/105, 422/117, 312/209, 435/299.2, 435/283.1, 435/304.1, 435/285.2, 435/284.1, 435/286.2, 435/288.1, 424/529
• US Class Current: 422/44
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: A61M 1/0281 Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
• CPC Class Codes: A61M 1/3623 Means for actively controlling temperature of blood
• CPC Class Codes: A61M 1/3626 Gas bubble detectors
• CPC Class Codes: A61M 1/3681 by irradiation
• CPC Class Codes: A61M 1/3687 Chemical treatment A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/369 Temperature treatment
• CPC Class Codes: A61M 2202/0216 Ozone
• CPC Class Codes: A61M 2205/052 infrared
• CPC Class Codes: A61M 2205/053 ultraviolet
• CPC Class Codes: A61M 2205/123 with incorporated reservoirs
• CPC Class Codes: A61M 2205/368 by electromagnetic radiation, e.g. IR waves
• CPC Class Codes: A61M 2205/75 with filters

Abstract

An apparatus for conditioning mammalian blood for subsequent use in a medical procedure includes a cabinet having a secure environment and a door providing the only access to the environment. An input system transports a blood charge from a source to the cabinet and a flask is removably contained in the secure environment and coupled to the charge input system to receive the charge. Stressors are coupled to the cabinet and positioned for operation to create a conditioned charge in the flask. An output system is coupled to the flask and includes a receiver for the conditioned charge. The apparatus includes an automated control system operable upon closing the door to lock the door and to then condition the charge, and to then cause the charge to move from the flask to the receiver.

Claims

1. A cabinet for use in conditioning mammalian blood for subsequent use in a medical procedure, a blood charge being conditioned in a flask and the cabinet having:

a front defining a front recess;

a top defining a depression adjacent to the front recess;

a door for movement between an open position and a closed position in which the front recess and the depression are covered by the door to create a secure environment;

a lock coupled to the cabinet and to the door to lock the door in the closed position;

a cavity extending downwardly from the top depression within the secure environment, the cavity being adapted to receive the flask; and

a control system coupled to the door lock to sense the condition of the door to establish that the flask is securely positioned in the cabinet, and that the door is locked before the charge is conditioned and further including an actuator in the front cavity for coupling to a syringe operator to activate the output syringe to draw the conditioned charge into the syringe within the secure environment.

2. A cabinet for use in conditioning mammalian blood for subsequent use in a medical procedure, a blood charge being conditioned in a flask and the cabinet having:

a front;

a top;

a door for movement between an open position and a closed position in which at least a portion of the front and a portion of the top are covered by the door to create a secure environment;

a lock coupled to the cabinet and to the door to lock the door in the closed position;

a cavity extending downwardly from the top wall within the secure environment, the cavity being adapted to receive the flask;

a control system coupled to the door lock to sense the condition of the door to establish that the flask is securely positioned in the cabinet, and that the door is locked before the charge is; and

an infrared source positioned below the cavity for operation to heat the charge when the flask is contained in the cavity to thereby condition the charge.

3. A cabinet as claimed in claim 2 and further including a mount for a receiver which receives the conditioned charge from the flask, the mount being positioned in the secure environment.

4. A cabinet as claimed in claim 3 and further including a knocker mounted adjacent said mount and positioned for striking the receiver repetitively to break up bubbles in the conditioned, charge.

5. A cabinet as claimed in claim 4 in which the knocker includes an impact tool for striking the receiver from one side and a spring mounted on the opposite side from the tool whereby when the tool impacts the receiver, the spring stores energy and rebounds to push the receiver towards the tool to start a new cycle.

6. A cabinet as claimed in claim 5 in which the knocker is coupled to the control system to cause the knocker to strike the receiver at a frequency of about one Hertz.

7. A cabinet as claimed in claim 2 and further including a mount on the front wall for an output syringe which receives the conditioned charge from the flask, the syringe being held by the mount with a syringe operator lowermost.

8. A cabinet as claimed in claim 2 and further including an actuator on the front wall for coupling to the operator to activate the output syringe to draw the conditioned charge into the syringe within the secure environment.

9. A cabinet as claimed in claim 2 and further including at least one heat sealer mounted for operation in the secure environment when the door is closed to seal and sever thermoplastic tubing used to make connections to the flask.

10. A cabinet for use in conditioning mammalian blood for subseciuent use in a medical procedure, a blood charge being conditioned in a flask and the cabinet having:

a front

a top;

a door for movement between an open position and a closed position in which at least a portion of the front and a portion of the top are covered by the door to create a secure environment;

a lock coupled to the cabinet and to the door to lock the door in the closed position;

a cavity extending downwardly from the top wall within the secure environment, the cavity being adapted to receive the flask;

a control system coupled to the door lock to sense the condition of the door to establish that the flask is securely positioned in the cabinet, and that the door is locked before the charge is conditioned; and

an ultraviolet source positioned about the cavity for operation to shine on the charge when the flask is contained in the cavity to thereby condition the charge.

11. A cabinet for use in conditioning mammalian blood for subsequent use in a medical procedure, a blood charge being conditioned in a flask and the cabinet having:

a front;

a top;

a door for movement between an open position and a closed position in which at least a portion of the front and a portion of the top are covered by the door to create a secure environment;

a lock coupled to the cabinet and to the door to lock the door in the closed position;

a cavity extending downwardly from the top wall within the secure environment, the cavity being adapted to receive the flask; and

a control system coupled to the door lock to sense the condition of the door to establish that the flask is securely positioned in the cabinet, and that the door is locked before the charge is conditioned and further comprising an ozone generator for receiving oxygen and converting at least some of the oxygen to ozone, and an ozone delivery system for coupling to the flask when the flask is in the cavity to bubble a mixture of ozone and oxygen into the charge to condition the charge.