Slide cartridge and reagent test slides for use with a chemical analyzer, and chemical analyzer for same

• US 7,273,591 B2
• Filed: 08/12/2003
• Issued: 09/25/2007
• Est. Priority Date: 08/12/2003
• Status: Active Grant

• Current Assignee: IDEXX Laboratories Incorporated
• Original Assignee: IDEXX Laboratories Incorporated
• Inventors: Kuba, Lawrence M., Taylor, Haydn B., Sellers, James M.
• Primary Examiner(s): Gordon; Brian R.
• Application Number:
  US10/639,031
• Publication Number:
  US 20050036911A1
• Time in Patent Office: 1,505 Days
• Field of Search: 422 99-100, 422/102, 422/104, 422/58, 422/64, 422/68.1
• US Class Current: 422/563
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2300/0803 Disc shape
• CPC Class Codes: B01L 2300/0822 Slides
• CPC Class Codes: B01L 9/52 Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
• CPC Class Codes: G01N 2035/00039 Transport arrangements specific to flat sample substrates, e.g. pusher blade
• CPC Class Codes: G01N 2035/00089 Magazines
• CPC Class Codes: G01N 2035/00138 Slides
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes

Abstract

A slide cartridge for use with a chemical analyzer includes an upper ring and a lower ring secured together but rotatable with respect to each other. The upper and lower rings define a plurality of reaction chambers between them, which receive dry analyte test slides. A gear track formed in the underside of the lower ring engages a pinion gear attached to a stepping motor of the chemical analyzer in order to rotate the slide cartridge. The slide cartridge is rotated under a sample fluid metering device, which deposits a sample fluid on the test slides through a plurality of spotter ports formed in the upper ring, and above a reflectometer, which performs a colorimetric measurement on the spotted test slides through viewing windows formed in the lower ring of the slide cartridge. A chemical analyzer with which the slide cartridge may be used includes a reflectometer, a sample fluid metering device and a stepping motor for rotating the slide cartridge.

Claims

1. A slide cartridge for use with a chemical analyzer and for holding therein a plurality of reagent test slides, which comprises:

a first ring; and

a second ring secured to the first ring, the first and second rings being at least partially rotatable relative to one another, the first ring including a first primary wall, and radially spaced apart inner and outer sidewalls extending perpendicularly from the first primary wall, the first primary wall having a top surface and including ribs protruding upwardly from the top surface, the ribs being spaced apart from one another periodically about the circumference of the first ring, adjacent ribs receiving therebetween a respective reagent test slide of the plurality of reagent test slides, the second ring and the inner and outer sidewalls and ribs of the first ring defining therebetween a plurality of reaction chambers for receiving the plurality of reagent test slides, the reaction chambers being arranged side-by-side circumferentially between the first and second rings and residing in a single plane, the slide cartridge being receivable by a chemical analyzer for testing the plurality of reagent test slides and being removable therefrom after testing of the plurality of reagent test slides has been performed by the chemical analyzer.

2. A slide cartridge as defined by claim 1, wherein the first primary wall of the first ring has formed through the thickness thereof a plurality of viewing windows, each viewing window of the plurality of viewing windows being positioned on the first primary wall in alignment with a respective reaction chamber of the plurality of reaction chambers, a reagent test slide received by a respective reaction chamber being at least partially exposed through a respective viewing window of the plurality of viewing windows.

3. A slide cartridge as defined by claim 1, wherein the first ring has formed therein a plurality of slide insertion openings, each slide insertion opening of the plurality of slide insertion openings being aligned with a respective reaction chamber of the plurality of reaction chambers and being in communication therewith to allow a reagent test slide to pass therethrough and into the respective reaction chamber.

4. A slide cartridge as defined by claim 3, wherein the first ring includes at least one sidewall;

and wherein the plurality of slide insertion openings are formed through the thickness of the at least one sidewall.

5. A slide cartridge as defined by claim 3, wherein the first primary wall of the first ring includes a plurality of resilient clips, each resilient clip of the plurality of resilient clips being positioned in proximity to a respective slide insertion opening of the plurality of slide insertion openings, each of the resilient clips being engageable with a reagent test slide received by a corresponding reaction chamber to help maintain the reagent test slide within the reaction chamber.

6. A slide cartridge as defined by claim 1, wherein the first ring includes an exposed surface, the exposed surface having formed thereon a circular track of gear teeth.

7. A slide cartridge as defined by claim 1, wherein the second primary wall of the second ring has formed through the thickness thereof a plurality of spaced apart spotter ports, the second ring being rotatable relative to the first ring such that each spotter port of the plurality of spotter ports is selectively positionable in at least partial alignment with a reagent test slide received by a respective reaction chamber of the plurality of reaction chambers.

8. A slide cartridge as defined by claim 1, wherein the second primary wall of the second ring includes a plurality of spaced apart reaction chamber caps, each reaction chamber cap of the plurality of reaction chamber caps being resiliently hinged to the second primary wall and residing in corresponding openings formed through the thickness of the second primary wall, the second ring being rotatable relative to the first ring such that each reaction chamber cap of the plurality of reaction chamber caps is selectively positionable in at least partial alignment with a reagent test slide received by a respective reaction chamber of the plurality of reaction chambers.

9. A slide cartridge as defined by claim 1, wherein the second ring includes a rotation control arm extending from the second primary wall thereof.

10. A slide cartridge as defined by claim 1, wherein adjacent ribs of the first ring are mutually diverging so as to closely receive therebetween a respective reagent test slide having a trapezoidal shape.

11. A slide cartridge for use with a chemical analyzer and for holding therein a plurality of reagent test slides, which comprises:

a first ring; and

a second ring secured to the first ring, the first and second rings being at least partially rotatable relative to one another, the first ring including a first primary wall and the second ring including a second primary wall, the first and second rings together defining therebetween a plurality of reaction chambers for receiving the plurality of reagent test slides, the reaction chambers being arranged side-by-side circumferentially between the first and second rings and residing in a single plane, the slide cartridge being receivable by a chemical analyzer for testing the plurality of reagent test slides and being removable therefrom after testing of the plurality of reagent test slides has been performed by the chemical analyzer;

wherein the first ring has formed therein a plurality of slide insertion openings, each slide insertion opening of the plurality of slide insertion openings being aligned with a respective reaction chamber of the plurality of reaction chambers and being in communication therewith to allow a reagent test slide to pass therethrough and into the respective reaction chamber; and

wherein the first primary wall of the first ring includes a major portion and deflectable portions resiliently hinged to the major portion, the deflectable portions being situated in alignment with corresponding reaction chambers, the deflectable portions of the first primary wall at least partially defining a respective slide insertion opening of the plurality of slide insertion openings.

12. A slide cartridge for use with a chemical analyzer and for holding therein a plurality of reagent test slides, which comprises:

a first ring; and

a second ring secured to the first ring, the first and second rings being at least partially rotatable relative to one another, the first ring including a first primary wall and the second ring including a second primary wall, the first and second rings together defining therebetween a plurality of reaction chambers for receiving the plurality of reagent test slides, the reaction chambers being arranged side-by-side circumferentially between the first and second rings and residing in a single plane, the slide cartridge being receivable by a chemical analyzer for testing the plurality of reagent test slides and being removable therefrom after testing of the plurality of reagent test slides has been performed by the chemical analyzer;

wherein the first ring includes at least one sidewall, the at least one sidewall including a plurality of spaced apart tabs, each tab of the plurality of tabs extending radially from the at least one sidewall into a respective reaction chamber of the plurality of reaction chambers, each tab of the plurality of tabs being partially superposed over the first primary wall and spaced apart therefrom a predetermined distance to allow a reagent test slide to be closely partially received between a corresponding tab and the first primary wall of the first ring.

13. A slide cartridge for use with a chemical analyzer and for holding therein a plurality of reagent test slides, which comprises:

a first ring; and

a second ring secured to the first ring, the first and second rings being at least partially rotatable relative to one another, the first ring including a first primary wall and the second ring including a second primary wall, the first and second rings together defining therebetween a plurality of reaction chambers for receiving the plurality of reagent test slides, the reaction chambers being arranged side-by-side circumferentially between the first and second rings and residing in a single plane, the slide cartridge being receivable by a chemical analyzer for testing the plurality of reagent test slides and being removable therefrom after testing of the plurality of reagent test slides has been performed by the chemical analyzer;

wherein the second ring includes a rotation control arm extending from the second primary wall thereof; and

wherein the rotation control arm extends through a slot formed in the first ring.

14. A slide cartridge for use with a chemical analyzer and for holding therein a plurality of reagent test slides, which comprises:

a first ring; and

a second ring secured to the first ring, the first and second rings being at least partially rotatable relative to one another, the first ring including a first primary wall and the second ring including a second primary wall, the first and second rings together defining therebetween a plurality of reaction chambers for receiving the plurality of reagent test slides, the reaction chambers being arranged side-by-side circumferentially between the first and second rings and residing in a single plane, the slide cartridge being receivable by a chemical analyzer for testing the plurality of reagent test slides and being removable therefrom after testing of the plurality of reagent test slides has been performed by the chemical analyzer;

wherein the first ring further includes first and second sidewalls radially disposed to one another in a spaced apart relationship and mounted on and extending substantially perpendicularly from the first primary wall; and

wherein the second ring further includes first and second sidewalls radially disposed to one another in a spaced apart relationship and mounted on and extending substantially perpendicularly from the second primary wall, the second ring being at least partially received by the first ring such that the first and second sidewalls of the second ring are interposed between the first and second sidewalls of the first ring.

15. A slide cartridge as defined by claim 14, wherein at least one of the first and second sidewalls of at least one of the first and second rings includes a plurality of spaced apart resilient clips disposed thereon;

and wherein at least one of the first and second sidewalls of the at least one of the first and second rings includes a plurality of spaced apart, notched out portions which define recessed edges within the notched out portions, the spacing between adjacent resilient clips and the spacing between adjacent notched out portions being substantially the same such that the resilient clips engage the recessed edges defined by the notched out portions when the second ring is partially received by the first ring and secured to the first ring thereby.

16. A slide cartridge for use with a chemical analyzer and for holding therein a plurality of reagent test slides, which comprises:

a first ring; and

a second ring secured to the first ring, the first and second rings being at least partially rotatable relative to one another, the first ring including a first primary wall and the second ring including a second primary wall, the first and second rings together defining therebetween a plurality of reaction chambers for receiving the plurality of reagent test slides, the reaction chambers being arranged side-by-side circumferentially between the first and second rings and residing in a single plane, the slide cartridge being receivable by a chemical analyzer for testing the plurality of reagent test slides and being removable therefrom after testing of the plurality of reagent test slides has been performed by the chemical analyzer;

wherein one of the first and second rings includes at least one hooked end mounted thereon, and the other of the first and second rings includes at least one flange mounted thereon, the at least one hooked end engaging the at least one flange to rotatably secure the first ring to the second ring.

17. In combination:

a slide cartridge for use with a chemical analyzer and for holding therein a plurality of reagent test slides, which comprises;

a first ring; and

a second ring secured to the first ring, the first and second rings being at least partially rotatable relative to one another, the first ring including a first primary wall, and radially spaced apart inner and outer sidewalls extending perpendicularly from the first primary wall, the first primary wall having a top surface and including ribs protruding upwardly from the top surface, the ribs being spaced apart from one another periodically about the circumference of the first ring, adjacent ribs receiving therebetween a respective reagent test slide of the plurality of reagent test slides, the second ring and the inner and outer sidewalls and ribs of the first ring defining therebetween a plurality of reaction chambers for receiving the plurality of reagent test slides, the reaction chambers being arranged side-by-side circumferentially between the first and second rings and residing in a single plane, the slide cartridge being receivable by a chemical analyzer for testing the plurality of reagent test slides and being removable therefrom after testing of the plurality of reagent test slides has been performed by the chemical analyzer; and

a plurality of reagent test slides, each reagent test slide of the plurality of test slides having a film portion carrying a chemical reagent, and a frame surrounding and supporting the film portion, the frame having at least two opposite edges which are non-parallel to each other, the plurality of reagent test slides being received by the slide cartridge such that the at least two opposite non-parallel edges of each reagent test slide are situated in close proximity to respective adjacent ribs of the first primary wall of the first ring, the reagent test slides being arranged side-by-side circumferentially between the first and second rings and residing in a single plane, each reagent test slide of the plurality of reagent test slides being received by a corresponding reaction chamber of the plurality of reaction chambers.

18. A combination as defined by claim 17, wherein adjacent ribs of the lower first ring which receive therebetween a respective reagent test slide extend in a substantially radial direction with respect to the first ring;

and wherein the at least two opposite non-parallel edges of a respective reagent test slide, when received between corresponding adjacent ribs in a corresponding reaction chamber, extend in a substantially radial direction with respect to the first ring.

19. A chemical analyzer for analyzing a plurality of reagent test slides, which comprises:

a reflectometer;

a sample fluid metering device;

a removable slide cartridge carrying a plurality of reagent test slides, the removable slide cartridge having a first ring and a second ring secured to the first ring, the first and second rings being at least partially rotatable relative to one another, the first ring including a first primary wall, and radially spaced, apart inner and outer sidewalls extending perpendicularly from the first primary wall, the first primary wall having a top surface and including ribs protruding upwardly from the top surface, the ribs being spaced apart from one another periodically about the circumference of the first ring, adjacent ribs receiving therebetween a respect reagent test slide of the plurality of reagent test slides, the second ring and the inner and outer sidewalls and ribs of the first ring defining therebetween a plurality of reaction chambers for receiving the plurality of reagent test slides, the reaction chambers being arranged side-by-side circumferentially between the first and second tings and residing in a single plane, the slide cartridge being receivable by the chemical analyzer for testing the plurality of reagent test slides and being removable therefrom after testing of the plurality of reagent test slides has been performed by the chemical analyzer.

20. A chemical analyzer as defined by claim 19, wherein the first ring of the slide cartridge includes an exposed surface having formed thereon a circular track of gear teeth;

and wherein the motor of the chemical analyzer includes a pinion gear operatively coupled thereto, the pinion gear engaging the circular track of gear teeth of the slide cartridge to rotate the slide cartridge.

21. A chemical analyzer as defined by claim 19, wherein the motor is a stepping motor.