Integrated on-chip NMR and ESR device and method for making and using the same
First Claim
1. A device comprising a substrate, the substrate comprising:
- a space for holding a liquid sample;
a magnet capable of generating a static magnetic field across at least a portion of the space; and
a microcoil capable of generating an excitation magnetic field across at least a portion of the space;
wherein the static magnetic field and the excitation magnetic field are capable of creating Nuclear Magnetic Resonance (NMR) or Electron Spin Resonance (ESR) within a liquid sample contained in the space; and
wherein the microcoil is capable of detecting signals from the NMR or ESR,wherein the substrate comprises an array of spaces for holding liquid samples and wherein each of at least a portion of the microcoils is capable of generating an excitation magnetic field across one of the spaces.
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Abstract
An embodiment if the invention relates to an integrated on-chip NMR or ESR device for performing chemical analysis and medical diagnostics. Specifically, the device contains, on a single substrate, a sample holding space, a magnet for generating a static magnetic field across the sample holding space and a microcoil for generating an excitation magnetic field across sample holding space. The magnetic fields are able to create NMR or ESR within a sample in the sample holding space and collect and/or process the signals from the NMR or ESR. The substrate may comprise an array of microcoils and sample holding spaces for performing multiple NMR or ESR analysis, such as multiple DNA analysis. Other embodiments of the invention relate methods for fabricating such devices and methods for performing NMR or ESR analysis using such devices.
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Citations
72 Claims
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1. A device comprising a substrate, the substrate comprising:
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a space for holding a liquid sample; a magnet capable of generating a static magnetic field across at least a portion of the space; and a microcoil capable of generating an excitation magnetic field across at least a portion of the space; wherein the static magnetic field and the excitation magnetic field are capable of creating Nuclear Magnetic Resonance (NMR) or Electron Spin Resonance (ESR) within a liquid sample contained in the space; and
wherein the microcoil is capable of detecting signals from the NMR or ESR,wherein the substrate comprises an array of spaces for holding liquid samples and wherein each of at least a portion of the microcoils is capable of generating an excitation magnetic field across one of the spaces. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method comprising:
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fabricating a space for holding a liquid sample on a substrate; attaching a magnet on the substrate, the magnet being capable of generating a static magnetic field across at least a portion of the space; and fabricating a microcoil on the substrate, the microcoil being capable of generating an excitation magnetic field across at least a portion of the space; wherein the static magnetic field and the excitation magnetic field are capable of creating Nuclear Magnetic Resonance (NMR) or Electron Spin Resonance (ESR) within a liquid sample contained in the space; and
wherein the microcoil is capable of detecting signals from the NMR or ESR,wherein the substrate comprises an array of spaces for holding liquid samples and wherein each or at least a portion of the microcoils is capable of generating an excitation magnetic field across one of the spaces. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. A method comprising:
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providing a device comprising a substrate;
the substrate comprising a space for holding a liquid sample, a magnet capable of generating a static magnetic field across at least a portion of the space, and a microcoil capable of generating an excitation magnetic field across at least a portion of the space;providing a liquid sample within the space; using the magnet to generate a static magnetic field across at least a portion of the sample; using the microcoil to generate an excitation magnetic field across at least a portion of the sample; using the microcoil to detect signals from the sample, wherein the substrate comprises an array of spaces for holding liquid samples and wherein each of at least a portion of the microcoils is capable of generating an excitation magnetic field across one of the spaces. - View Dependent Claims (35, 36, 37, 38)
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39. A device comprising a substrate, the substrate comprising:
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a space for holding a liquid sample; and an array of microcoils capable of generating excitation magnetic fields across at least a portion of the space; wherein the excitation magnetic fields are capable of creating NMR or ESR within a liquid sample contained in the space when the sample is immersed in an static magnetic field; and
wherein the microcoils are capable of detecting signals from the NMR or ESR,wherein the substrate comprises an array of spaces for holding liquid samples and wherein each of at least a portion of the microcoils is capable of generating an excitation magnetic field across one of the spaces. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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61. A method comprising:
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providing a device comprising a substrate, the substrate comprising a space for holding a liquid sample and an array of microcoils capable of generating an excitation magnetic field across at least a portion of the space; providing a liquid sample within the space; generating a static magnetic field across at least a portion of the sample; using at least a portion of the microcoils to generate excitation magnetic fields across at least a portion of the sample; and using at least a portion of the microcoils to detect signals from the sample, wherein the substrate comprises an array of spaces for holding liquid samples and wherein each of at least a portion of the microcoils is capable of generating an excitation magnetic field across one of the spaces. - View Dependent Claims (62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72)
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Specification