System and method for three-dimensional image rendering and analysis
First Claim
Patent Images
1. A method of estimating volumetric doubling time (DT) of an object which changes size, said object found in a mammalian host, comprising:
- a. obtaining a measurement of a change of a volumetric characteristic of an object in a mammal over a time period, said object characterized as changing in size over a time period, said measurement of said change of said volumetric characteristic being obtained from an object at a first time (t1) and at a later second time (t2);
b. relating said change in said volumetric characteristic found in step (a) to said time period via an exponential size change model; and
c. determining an estimated doubling time (DT) by comparing volume change over said time period comprising;
(i) defining a minimum-detectable size dimension β
; and
(ii) calculating doubling time using volume measurement at t2 and a volume measurement derived from said minimum-detectable size dimension β
, and the time period (Δ
ts) between t1 and t2.
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Abstract
The present invention relates to methods and systems for conducting three-dimensional image analysis and diagnosis and possible treatment relating thereto. The invention includes methods of handling signals containing information (data) relating to three-dimensional representation of objects scanned by a scanning medium. The invention also includes methods of making and analyzing volumetric measurements and changes in volumetric measurements which can be used for the purpose of diagnosis and treatment.
138 Citations
48 Claims
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1. A method of estimating volumetric doubling time (DT) of an object which changes size, said object found in a mammalian host, comprising:
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a. obtaining a measurement of a change of a volumetric characteristic of an object in a mammal over a time period, said object characterized as changing in size over a time period, said measurement of said change of said volumetric characteristic being obtained from an object at a first time (t1) and at a later second time (t2); b. relating said change in said volumetric characteristic found in step (a) to said time period via an exponential size change model; and c. determining an estimated doubling time (DT) by comparing volume change over said time period comprising; (i) defining a minimum-detectable size dimension β
; and(ii) calculating doubling time using volume measurement at t2 and a volume measurement derived from said minimum-detectable size dimension β
, and the time period (Δ
ts) between t1 and t2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An article of manufacture for estimating volumetric doubling time (DT) of an object which changes size, said object found in a mammalian host, comprising:
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a machine readable-medium containing one or more programs which when executed implement the steps of; a. obtaining a measurement of a change of a volumetric characteristic of an object in a mammal over a time period, said object characterized as changing in size over a time period, said measurement of said change of said volumetric characteristic being obtained from an object at a first time (t1) and at a later second time (t2); b. relating said change in said volumetric characteristic found in step (a) to said time period via an exponential size change model; and c. determining an estimated doubling time (DT) by comparing volume change over said time period comprising; (i) defining a minimum-detectable size dimension β
; and(ii) calculating doubling time using volume measurement at t2 and a volume measurement derived from said minimum-detectable size dimension β
, and the time period (Δ
ts) between t1 and t2. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A system for estimating volumetric doubling time (DT) of an object which changes size, said object found in a mammalian host, comprising:
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a processor configured to; a. obtain a measurement of a change of a volumetric characteristic of an object in a mammal over a time period, said object characterized as changing in size over a time period, said measurement of said change of said volumetric characteristic being obtained from an object at a first time (t1) and at a later second time (t2). b. relate said change in said volumetric characteristic found in step (a) to said time period via an exponential size change model; and c. determine an estimated doubling time (DT) by comparing volume change over said time period comprising; (i) define a minimum-detectable size dimension β
; and(ii) calculate doubling time using volume measurement at t2 and a volume measurement derived from said minimum-detectable size dimension β
, and the time period (Δ
ts) between t1 and t2. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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Specification