Wound and ulcer treatment with super-oxidized water

• US 7,276,255 B2
• Filed: 04/23/2004
• Issued: 10/02/2007
• Est. Priority Date: 08/23/1999
• Status: Expired due to Term

• Current Assignee: Urgo US, Inc.
• Original Assignee: Sterilox Medical Limited
• Inventors: Selkon, Joe B.
• Primary Examiner(s): PAK, JOHN D
• Application Number:
  US10/830,878
• Publication Number:
  US 20040208940A1
• Time in Patent Office: 1,257 Days
• Field of Search: 424/661, 424/663, 424/665, 424/484, 424/488, 514/886, 514/887, 514/925, 514/944, 205/556, 205/701
• US Class Current: 424/665
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C02F 1/4674 with halogen or compound of halogens, e.g. chlorine, bromine
• CPC Class Codes: C02F 2103/026 Treating water for medical or cosmetic purposes
• CPC Class Codes: C02F 2209/04 Oxidation reduction potential [ORP]
• CPC Class Codes: C02F 2209/06 pH
• CPC Class Codes: C02F 2303/04 Disinfection

Abstract

Super-oxidized water based on hypochlorous acid, such as is obtained by the electrochemical treatment of a saline solution, may be used in the treatment of leg ulcers or other open wounds. Preferably, the pH of the super-oxidized water is in a range of 4 to 7, and the water has a redox potential of >950 mV. Medicaments based on the super-oxidized water may be in liquid or gel form. The super-oxidized water is able to control the microbial population within the wound and at the same time permit cell proliferation.

Claims

1. A method for treating an open wound in a human or animal body comprising administering to the open wound an output solution comprising hypochlorous acid,

said output solution:

having a pH of 4 to 7, a redox potential of >

950 mV, and being obtained by electrochemical treatment of a saline solution; and

wherein the output solution is administered in an amount effective to act as a biocide and permit cell proliferation for wound healing.

2. The method according to claim 1, wherein the open wound is an ulcer, burn, or surface wound.

3. The method according to claim 1, wherein the output solution is in a liquid form and is applied to the wound by bathing.

4. The method according to claim 3, wherein the output solution is applied to the wound by immersion in a hydrobath containing the output solution.

5. The method according to claim 1, wherein the output solution is in a liquid form and is applied to the wound by spraying.

6. The method according to claim 1, wherein the output solution is in a gel form and is topically applied to the wound.

7. The method according to claim 1, wherein the output solution has a pH of 4.0 to 6.5.

8. The method according to claim 7, wherein the output solution has a pH of 4.0 to 6.2.

9. The method according to claim 8, wherein the output solution has a pH of 4.3 to 6.2.

10. The method according to claim 9, wherein the output solution has a pH of about 5.4.

11. The method according to claim 1, wherein the output solution has a redox potential of about 1000 mV.

12. The method according to claim 1, wherein the output solution, or a preparation derived therefrom, has a biocide rate (D Value) of approximately 1 log reduction unit bacillus subtilis spores in less than 1 minute with a 9:

1 output solution;

innoculum mix.

13. The method according to claim 1, wherein the output solution is diluted.

14. The method according to claim 13, wherein the output solution is diluted to an extent that it promotes cell proliferation.

15. The method according to claim 1, wherein the output solution has a pH adjusted to a desired level by using an alkaline solution output from an electrochemical cell in which the saline solution is treated.

16. The method according to claim 1, wherein the output solution further comprises a phosphate buffer to adjust a pH of the solution to a desired level.

17. The method according to claim 1, wherein the output solution has an available free chlorine concentration of about 144 mg/l to 400 mg/l.

18. A method for treating an open wound in a mammal comprising administering to the open wound an output solution obtained by electrochemical treatment of a saline solution, the output solution comprising hypochlorous acid, having an available free chlorine concentration of about 144 mg/l to 400 mg/l, and having a pH of 4 to 7, wherein the output solution is administered in an amount effective to act as a biocide and permit cell proliferation for wound healing.

19. The method according to claim 18, wherein the open wound is an ulcer, burn, or surface wound.

20. The method according to claim 18, wherein the output solution is in a liquid form and is applied to the wound by bathing.

21. The method according to claim 18, wherein the output solution is applied to the wound by immersion in a hydrobath containing the output solution.

22. The method according to claim 18, wherein the output solution is in a liquid form and is applied to the wound by spraying.

23. The method according to claim 18, wherein the output solution is in a gel form and is topically applied to the wound.

24. The method according to claim 18, wherein the output solution has a pH of 4.0 to 6.5.

25. The method according to claim 18, wherein the output solution has a pH of 4.0 to 6.2.

26. The method according to claim 18, wherein the output solution has a pH of 4.3 to 6.2.

27. The method according to claim 18, wherein the output solution has a pH of about 5.4.

28. The method according to claim 18, wherein the output solution has a redox potential of >

950 mV.

29. The method according to claim 18, wherein the output solution has a redox potential of about 1000 mV.

30. The method according to claim 18, wherein the output solution, or a preparation derived therefrom, has a biocide rate (D Value) of approximately 1 log reduction unit bacillus subtilis spores in less than 1 minute with a 9:

1 output solution;

innoculum mix.

31. The method according to claim 18, wherein the output solution is diluted.

32. The method according to claim 18, wherein the output solution is diluted to an extent that it promotes cell proliferation.

33. The method according to claim 18, wherein the output solution has a pH adjusted to a desired level by using an alkaline solution output from an electrochemical cell in which the saline solution is treated.

34. The method according to claim 18, wherein the output solution further comprises a phosphate buffer to adjust a pH of the solution to a desired level.