Methods of making and using surfactant polymers
First Claim
1. A method of reducing the thrombogenicity of a hydrophobic surface of a substrate comprising:
- a) providing a comblike surfactant polymer comprising;
i) a polymeric backbone of repeating monomeric units,ii) a plurality of hydrophobic side chains comprising from about 2 to about 18 methylene groups, said plurality of hydrophobic side chains being linked to said polymeric backbone by ester linkages, secondary amine linkages, amide linkages;
or combinations thereof andiii) a plurality of hydrophilic side chains linked to said polymeric backbone by ester linkages, secondary amine linkages, amide linkages, or combinations thereof;
said hydrophilic side chains selected from the group consisting of;
neutral oligosaccharide side chains having a weight average molecular weight of less than 7000;
charged oligosaccharide side chains having a weight average molecular weight of less than 10,000, polyethylene oxide; and
combinations thereof,b) attaching the comblike surfactant polymer to the hydrophobic substrate to provide a substrate with reduced thrombogenicity.
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Accused Products
Abstract
Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages. The hydrophilic side chain is selected from the group consisting of: a neutral oligosaccharide, which, preferably, has weight average molecular weight of less than 7000; a charged oligosaccharide, preferably a negatively charged oligosaccharide having a weight average molecular weight of less than 10,000; an oligopeptide of from about 3 to about 30 amino acid residues, said oligopeptide having an amino acid sequence which interacts with protein receptors on the surface of cells; and combinations thereof. Methods of making the surfactant polymers and using the surfactant polymers to alter the surface properties of a biomaterial are also provided.
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Citations
9 Claims
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1. A method of reducing the thrombogenicity of a hydrophobic surface of a substrate comprising:
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a) providing a comblike surfactant polymer comprising; i) a polymeric backbone of repeating monomeric units, ii) a plurality of hydrophobic side chains comprising from about 2 to about 18 methylene groups, said plurality of hydrophobic side chains being linked to said polymeric backbone by ester linkages, secondary amine linkages, amide linkages;
or combinations thereof andiii) a plurality of hydrophilic side chains linked to said polymeric backbone by ester linkages, secondary amine linkages, amide linkages, or combinations thereof;
said hydrophilic side chains selected from the group consisting of;
neutral oligosaccharide side chains having a weight average molecular weight of less than 7000;
charged oligosaccharide side chains having a weight average molecular weight of less than 10,000, polyethylene oxide; and
combinations thereof,b) attaching the comblike surfactant polymer to the hydrophobic substrate to provide a substrate with reduced thrombogenicity. - View Dependent Claims (2)
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3. A method of promoting attachment of endothelial cells to the surface of a hydrophobic surface comprising:
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a) providing a comblike surfactant polymer comprising; i) a polymeric backbone of repeating monomeric units, ii) a plurality of hydrophobic side chains comprising from about 2 to about 18 methylene groups, said plurality of hydrophobic side chains being linked to said polymeric backbone by secondary amine linkages, amide linkages;
or combinations thereof andiii) a plurality of hydrophilic side chains linked to said polymeric backbone by secondary amine linkages said hydrophilic side chains comprising an oligopeptide of from about 3 to 30 amino acid residues and having an amino acid sequence which interacts with protein receptors on the surface of endothelial cells b) attaching the comblike surfactant polymer to the hydrophobic substrate. - View Dependent Claims (4)
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5. A method of preparing a surfactant polymer for changing the surface properties of a biomaterial comprising the following steps:
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a) providing a polymer comprising a plurality of side groups selected from the group consisting of OH groups, COOH groups and NH2 groups; b) reacting said polymer with i) an alkanoyl or an alkanal having an end for reacting with the side groups of said polymer; and ii) a hydrophilic compound selected from the group consisting of neutral oligosaccharide chains having an end for reacting with the side groups of said polymer, charged oligosaccharide chains having an end for reacting with the side groups of said polymer, oligopeptides having an end for reacting with the side groups of said polymer, and combinations thereof; wherein said alkanal and said alkanoyl comprise from 2 to 18 methylene groups; wherein said neutral oligosaccharide chains have a weight average molecular weight of less than 7000; wherein said charged oligosaccharide chains have a weight average molecular weight of less than 10,000; and wherein said oligopeptides comprise from about 3 to 30 amino acid residues and a sequence which interact with protein receptors on the surface of endothelial cells. - View Dependent Claims (6, 7, 8, 9)
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Specification