Implantable myocardial ischemia detection, indication and action technology
First Claim
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1. A method for monitoring electrogram signals in a subject, comprising:
- acquiring electrogram signals within the subject by positioning a plurality of sensors transveneously within the subject, the electrogram signals including a depolariztion wave region and a repolarization wave region, the sensors electrically coupled to an implanted device including electronics therein;
analyzing the depolarization wave region of the electrogram signals using the implanted device to obtain information relating to changes in the depolarization wave region; and
determining whether MI/I has occurred, using the information relating to changes in the depolarization wave region.
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Abstract
One embodiment enables detection of MI/I and emerging infarction in an implantable system. A plurality of devices may be used to gather and interpret data from within the heart, from the heart surface, and/or from the thoracic cavity. The apparatus may further alert the patient and/or communicate the condition to an external device or medical caregiver. Additionally, the implanted apparatus may initiate therapy of MI/I and emerging infarction.
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Citations
31 Claims
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1. A method for monitoring electrogram signals in a subject, comprising:
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acquiring electrogram signals within the subject by positioning a plurality of sensors transveneously within the subject, the electrogram signals including a depolariztion wave region and a repolarization wave region, the sensors electrically coupled to an implanted device including electronics therein; analyzing the depolarization wave region of the electrogram signals using the implanted device to obtain information relating to changes in the depolarization wave region; and determining whether MI/I has occurred, using the information relating to changes in the depolarization wave region. - View Dependent Claims (2)
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3. A method for monitoring electrogram signals in a subject, comprising:
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acquiring electrogram signals from the subject'"'"'s heart, the electrogram signals including a depolariztion wave region and a repolarization wave region; analyzing the depolarization wave region of the electrogram signals using electronics positioned within the subject, wherein the analyzing includes obtaining depolarization information relating to changes in the depolarization wave region due to MI/I; analyzing the repolarization wave region of the electrogram signals using the electronics positioned within the subject, wherein the analyzing includes obtaining repolarization information relating to changes in the repolarization wave region due to MI/I; and determining, in the subject, whether MI/I has occurred, using the depolarization information and the repolarization information.
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- 4. A method of detecting myocardial ischemia in a subject, comprising analyzing an electrogram signal by determining its temporal features synchronous to the Q, R, S, and T waves in a surface ECG signal, wherein determining its temporal features synchronous to the Q, R, S, and T waves includes providing a plurality of sensors adapted to deliver signals to a device implanted in the subject, storing an electrogram signal from each lead into a digital memory in the device, and comparing an acquired electrogram signal to the stored electrogram signal.
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9. A method for distinguishing normal and ischemic signal information comprising:
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analyzing signals derived from a plurality of sensors implanted transveneously in a subject, the sensors adapted to obtain signals comprising a waveform of at least one heartbeat, the waveform including a depolarization region and a repolarization region; wherein the analyzing signals comprises analyzing the waveform using at least one method selected from the group consisting of a temporal domain method and a frequency domain method, wherein the temporal domain method comprises determining a magnitude of a signal power over the depolarization region and repolarization region of at least one heartbeat; and wherein the frequency domain method comprises performing a spectral analysis of a frequency component of the waveform over the depolarization region and the repolarization region of at least one heartbeat. - View Dependent Claims (10, 11, 12, 13)
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14. A method for monitoring a subject for MI/I, wherein a pacemaker is connected to the subject'"'"'s heart, the method comprising:
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acquiring a paced electrogram signal within the subject, the paced electrogram signal including a depolarization wave region and a repolarization wave region; obtaining information relating to changes in the depolarization wave region over a plurality of heartbeats; obtaining additional information relating to changes in the repolarization wave region over a plurality of heartbeats; and analyzing the information relating to changes in the depolarization wave region and the additional information relating to changes in the repolarization wave region using electronics positioned in the subject and determining whether MI/I has occurred.
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15. A method for treating a subject comprising:
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implanting a device in the subject; acquiring electrogram signals within the subject using the device, the electrogram signals including a depolariztion wave region and a repolarization wave region; determining whether MI/I has occurred in the subject using the device in the subject, wherein the determining whether MI/I has occurred includes one of;
(i) analyzing the depolarization wave region of the electrogram signals, wherein the analyzing includes obtaining depolarization information relating to changes in the depolarization wave region due to MI/I, or (ii) analyzing the depolarization wave region and the repolarization wave region of the electrogram signals, wherein the analyzing includes obtaining depolarization and repolarization information relating to changes in the depolarization and repolarization wave regions;generating a therapy signal in the device when a determination that MI/I has occurred is made; and initiating a therapy in the subject based on the therapy signal generated by the device. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. An apparatus for determining the location of a MI/I event in a subject, comprising an implantable device including a plurality of sensors adapted to be positioned in and around the heart, the device further including means for analyzing the changes in electrogram signals received from the sensors and means for determining the location using dipole projection.
Specification