Respiratory nerve stimulation

• US 7,277,757 B2
• Filed: 10/31/2002
• Issued: 10/02/2007
• Est. Priority Date: 10/31/2002
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Havel, William J., Casavant, David A.
• Primary Examiner(s): Layno; Carl
• Assistant Examiner(s): SARCIONE, JESSICA LYNN
• Application Number:
  US10/284,899
• Publication Number:
  US 20040088015A1
• Time in Patent Office: 1,797 Days
• Field of Search: 607/42, 607/2, 607/9, 607 4- 5, 607/118, 600/484, 600/515, 600/516
• US Class Current: 607/42
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 2001/0585 Coronary sinus electrodes

Abstract

The invention is directed to an implantable medical device that stimulates a nerve associated with respiration. The nerve may, for example be a phrenic nerve, and the stimulation may cause a diaphragm of the patient to contract. The implantable medical device receives a signal that indicates a need for increased cardiac output and stimulates the nerve in response to the signal. The implantable medical device may receive such a signal by, for example, detecting a ventricular tachyarrhythmia, sensing a pressure that indicates a need for increased cardiac output, or receiving a signal from a patient via a patient activator. Stimulation of the nerve may increase cardiac output of a beating or defibrillating heart.

Claims

1. A method comprising:

receiving a signal that indicates a need for increased cardiac output of a heart of a patient;

stimulating a nerve associated with respiration of the patient in response to the signal, wherein stimulating a nerve further includes

detecting an intrinsic cardiac event;

stimulating the nerve based on the detection, wherein stimulating the nerve further comprises;

identifying a period of ventricular filling of the heart based on the detected event;

identifying a time to stimulate the nerve in order to decrease pressure within a thoracic cavity during the period of ventricular filling; and

stimulating the nerve at the identified time.

2. A method comprising:

receiving a signal that indicates a need for increased cardiac output of a heart of a patient;

stimulating a nerve associated with respiration of the patient in response to the signal, wherein stimulating a nerve further includes

detecting an intrinsic cardiac event;

stimulating the nerve based on the detection, wherein stimulating the nerve further comprises;

identifying a period of ventricular contraction of the heart based on the detected event;

identifying a time to stimulate the nerve in order to increase pressure within a thoracic cavity during the period of ventricular contraction; and

stimulating the nerve at the identified time.

3. A device comprising:

an implantable medical device that receives a signal that indicates a need for increased cardiac output of a heart of a patient, and stimulates a nerve associated with respiration of the patient in response to the signal;

an electrode;

a processor to receive a signal that indicates a need for increased cardiac output of a heart of a patient, and direct an output circuit to stimulate a nerve associated with respiration of the patient via the electrode in response to the signal, wherein the processor detects an intrinsic cardiac event via the electrode, and directs the output circuit to stimulate the nerve based on the detection and the processor identifies a period of ventricular filling of the heart based on the detected event, identifies a time to stimulate the nerve in order to decrease pressure within a thoracic cavity during the period of ventricular filling, and stimulating the nerve at the identified time.

4. A device comprising:

an implantable medical device that receives a signal that indicates a need for increased cardiac output of a heart of a patient, and stimulates a nerve associated with respiration of the patient in response to the signal;

an electrode;

a processor to receive a signal that indicates a need for increased cardiac output of a heart of a patient, and direct an output circuit to stimulate a nerve associated with respiration of the patient via the electrode in response to the signal, wherein the processor detects an intrinsic cardiac event via the electrode, and directs the output circuit to stimulate the nerve based on the detection and the processor identifies a period of ventricular contraction of the heart based on the detected event, identifies a time to stimulate the nerve in order to increase pressure within a thoracic cavity during the period of ventricular contraction, and stimulating the nerve at the identified time.

5. The device of claim 4, wherein the electrode is a first electrode and the output circuit is a first output circuit, the device further comprising:

a second electrode; and

a second output circuit, wherein the processor directs the first output circuit to stimulate a right phrenic nerve via the first electrode, and directs the second output circuit to stimulate the left phrenic nerve via the second electrode.

6. A computer-readable medium comprising instructions that cause a processor to direct an output circuit to stimulate a nerve associated with respiration of a patient via an electrode in response to a signal that indicates a need for increased cardiac output of a heart of a patient and to detect an intrinsic cardiac event via the electrode, and wherein the instructions that cause a processor to direct the output circuit to stimulate the nerve comprise instructions that cause the processor to direct the output circuit to stimulate the nerve based on the detection, wherein the instructions that cause the processor to direct the output circuit to stimulate the nerve comprise instructions that cause a processor to:

identify a period of ventricular filling of the heart based on the detected event;

identify a time to stimulate the nerve in order to decrease pressure within a thoracic cavity during the period of ventricular filling; and

stimulate the nerve at the identified time.

7. A computer-readable medium comprising instructions that cause a processor to direct an output circuit to stimulate a nerve associated with respiration of a patient via an electrode in response to a signal that indicates a need for increased cardiac output of a heart of a patient and that cause a processor to detect an intrinsic cardiac event via the electrode, wherein the instructions that cause a processor to direct the output circuit to stimulate the nerve comprise instructions that cause the processor to direct the output circuit to stimulate the nerve based on the detection, wherein the instructions that cause a processor to direct the output circuit to stimulate the nerve comprise instructions that cause a processor to:

identify a period of ventricular contraction of the heart based on the detected event;

identify a time to stimulate the nerve in order to increase pressure within a thoracic cavity during the period of ventricular contraction; and

stimulate the nerve at the identified time.