Method of manufacture of smart microfluidic medical device with universal coating

• US 7,279,112 B2
• Filed: 05/22/2003
• Issued: 10/09/2007
• Est. Priority Date: 04/28/2000
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Martinez, Gonzalo
• Primary Examiner(s): Ahmed; Shamim
• Application Number:
  US10/443,274
• Publication Number:
  US 20030199741A1
• Time in Patent Office: 1,601 Days
• Field of Search: 216/2, 216/41, 216/37, 216/65, 427/563, 438/689, 438/733
• US Class Current: 216/37
• CPC Class Codes: A61B 2562/02 Details of sensors specially adapted for in-vivo measurements
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61L 29/103 Carbon
• CPC Class Codes: A61L 29/106 Inorganic materials other than carbon
• CPC Class Codes: A61L 31/084 Carbon; Graphite
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: A61M 2205/0238 the material being a coating or protective layer
• CPC Class Codes: A61M 2205/0255 in acidic environments or acidic fluids
• CPC Class Codes: A61M 2205/0261 in alcalic environments or alcalic fluids
• CPC Class Codes: A61M 5/14276 specially adapted for implantation

Abstract

A method of applying a universal coating for a medical device comprising a medical device component, the medical device component having an outer surface and an inner surface, the universal coating applied to at least the outer surface or the inner surface of the medical device component, wherein the coating is made from a material selected from the group consisting of diamond, diamond-like, borosilicate glass, carbides and nitrides. The medical device can further be a smart medical device by incorporating a sensor placed capable of measuring chemical and/or electrical conditions. A method of applying the coating inside complicated 3D structures without the need for bonding diamond to diamond or DLC to DLC layers is also provided.

Claims

1. A method of manufacture of a medical device, comprising:

(a) fabricating a three dimensional structure out of a melting point material using a micromolding process;

(b) depositing a film selected from the group consisting of diamond, diamond-like, borosilicate glass, carbide, nitride, or silicon material to cover the three dimensional structure;

(c) creating at least one opening in the film;

(d) melting the melting point material, and

(e) removing the melting point material via the at least one opening in the film.

2. The method of claim 1, wherein the step of creating at least one opening in the film comprises microdrilling.

3. The method of claim 1, wherein the step of creating at least one opening in the film comprises laser ablading.

4. The method of claim 1, wherein the step of creating at least one opening in the film comprises applying high pressure water to the structure.

9. The method of claim 1, further comprising the step of applying a support structure to the film opposite the side of the melting point material prior to removing the melting point material from the film.

10. The method of claim 1, further comprising the step of placing a sensor between the film and an implantable medical device component or within the film.

11. The method of claim 10, wherein the sensor measures a bioelectric event or substance to be detected.

12. The method of claim 11, wherein the sensor is electronically connected to a microprocessor controlling drug delivery by an implantable medical device.

13. The method of claim 11 wherein the sensor is an optical sensor.

14. The method of claim 11 wherein the sensor is an electrochemical sensor.

15. The method of claim 11 wherein the sensor is a boron doped area.

16. The method of claim 15 wherein the boron doped area is in contact with a sputtered metal piece.

17. The method of claim 11, wherein the sensor is electronically connected to a microprocessor controlling electrical stimulation by an implantable medical device.

5. A method of manufacture of a medical device, comprising:

(a) fabricating a three dimensional structure substrate out of a chemically dissolvable material using a micromolding process;

(b) depositing a film selected from the group consisting of diamond, diamond-like, borosilicate glass, carbide, nitride, or silicon material to completely cover the three dimensional structure;

(c) creating at least one opening in the film;

(d) dissolving the chemically dissolvable material; and

(e) removing the melting point material via the at least one opening in the film.

6. The method of claim 5, wherein the step of creating at least one opening in the film comprises microdrilling.

7. The method of claim 5 wherein the step of creating at least one opening in the film comprises laser ablading.

8. The method of claim 5, wherein the step of creating at least one opening in the film comprises applying high pressure water to the film.

18. The method of claim 5, further comprising the step of applying a support structure to the film opposite the side of the melting point material prior to removing the melting point material from the film.

19. The method of claim 5, further comprising the step of placing a sensor between the film and an implantable medical device component or within the film.

20. The method of claim 19, wherein the sensor measures a bioelectric event or substance to be detected.

21. The method of claim 19, wherein the sensor is electronically connected to a microprocessor controlling drug delivery by an implantable medical device.

22. The method of claim 19 wherein the sensor is an optical sensor.

23. The method of claim 19 wherein the sensor is an electrochemical sensor.

24. The method of claim 19 wherein the sensor is a boron doped area.

25. The method of claim 24 wherein the boron doped area is in contact with a sputtered metal piece.

26. The method of claim 19, wherein the sensor is electronically connected to a microprocessor controlling electrical stimulation by an implantable medical device.