Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases

• US 7,279,502 B2
• Filed: 10/20/2004
• Issued: 10/09/2007
• Est. Priority Date: 04/30/1999
• Status: Expired due to Fees

• Current Assignee: Cellgate, Inc. (Tbg Diagnostics Limited)
• Original Assignee: Cellgate, Inc. (Tbg Diagnostics Limited)
• Inventors: Marton, Laurence J.
• Primary Examiner(s): Russel; Jeffrey Edwin
• Application Number:
  US10/970,089
• Publication Number:
  US 20050233943A1
• Time in Patent Office: 1,084 Days
• US Class Current: 514/659
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 47/65 Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
• CPC Class Codes: A61P 13/08 of the prostate
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07C 211/13 Amines containing three or more amino groups bound to the carbon skeleton
• CPC Class Codes: C07C 211/18 containing at least two amino groups bound to the carbon skeleton
• CPC Class Codes: C07C 2601/02 with a three-membered ring
• CPC Class Codes: C07C 45/46 Friedel-Crafts reactions
• CPC Class Codes: C07C 47/575 containing ether groups, groups, groups, or groups
• CPC Class Codes: C07C 67/343 by increase in the number of carbon atoms
• CPC Class Codes: C07C 69/734 Ethers
• CPC Class Codes: C07D 207/34 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 219/10 attached in position 9
• CPC Class Codes: C07D 235/18 with aryl radicals directly attached in position 2
• CPC Class Codes: C07D 295/185 from aliphatic carboxylic acids
• CPC Class Codes: C07D 307/79 with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
• CPC Class Codes: C07D 307/92 Naphthofurans; Hydrogenated naphthofurans
• CPC Class Codes: C07D 311/92 Naphthopyrans; Hydrogenated naphthopyrans
• CPC Class Codes: C07D 317/70 : condensed with ring systems containing two or more relevant rings
• CPC Class Codes: C07D 493/04 : Ortho-condensed systems
• CPC Class Codes: C07K 5/1013 : the side chain containing O or S as heteroatoms, e.g. Cys, Ser
• CPC Class Codes: C07K 7/06 : having 5 to 11 amino acids

Abstract

Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.

Claims

1. A compound of the formula:

2. A composition of matter comprising a compound of claim 1 and a pharmaceutically acceptable excipient.

3. A compound of the formula:

4. A composition of matter comprising a compound of claim 3 and a pharmaceutically acceptable excipient.

5. A compound of the formula:

6. A composition of matter comprising a compound of claim 5 and a pharmaceutically acceptable excipient.