Composition and method for cleaning lipid deposits on contact lenses

• US 7,282,178 B2
• Filed: 05/30/2006
• Issued: 10/16/2007
• Est. Priority Date: 06/03/2005
• Status: Expired due to Fees

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Salamone, Joseph C., Barniak, Vicki, Borazjani, Roya, Manchester, Robert, McCanna, David
• Primary Examiner(s): Mruk; Brian
• Application Number:
  US11/442,789
• Publication Number:
  US 20060276358A1
• Time in Patent Office: 504 Days
• Field of Search: 510/112, 510/421, 510/475, 510/505, 422/28, 134/42
• US Class Current: 422/28
• CPC Class Codes: C11D 1/008 Polymeric surface-active agents
• CPC Class Codes: C11D 1/72 Ethers of polyoxyalkylene glycols
• CPC Class Codes: C11D 1/8255 containing a combination of compounds differently alcoxylised or with differently alkylated chains
• CPC Class Codes: C11D 2111/20 Industrial or commercial equipment, e.g. reactors, tubes or engines
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/3707 Polyethers, e.g. polyalkyleneoxides
• CPC Class Codes: C11D 3/3723 Polyamines or polyalkyleneimines

Abstract

This invention is directed to an aqueous composition and methods for clean lipid deposits on contact lenses. In particular, a combination of non-ionic surfactants, branched and/or straight poly(ethylene oxide-propylene oxide) (PEO-PPO) block copolymers having HLB value greater than or equal to 18, with an additional straight poly(ethylene oxide-propylene oxide) (PEO-PPO) block copolymers having HLB value less than or equal to 15, has been found to improve the lipid cleaning properties of an aqueous composition for contact lenses and prevent the overgrowth of harmful bacteria, yeast and molds without adversely affecting the comfort or safety in terms of the level of toxicity to eye tissue.

Claims

1. An aqueous composition for cleaning lipid deposits or for minimizing lipid deposition on a contact lens, said composition comprising:

a poloxamine having an HLB value greater than or equal to 18;

a poloxamer having an HLB value less than or equal to 15, and is present in an amount effective to improve the lipid cleaning effect of the composition;

a straight chain polyether surfactant having an HLB value greater than or equal to 18;

one or more antimicrobial agents present in an amount effective to disinfect or preserve the composition; and

a buffering agent, and an osmolality adjusting agent, wherein the osmolality adjusting agent is present to provide an osmolality of from 200 to 400 mOsm/kg.

2. The aqueous composition of claim 1, wherein the weight ratio of the poloxamine to the straight chain polyether surfactant having an HLB value greater than or equal to 18 is about one to two.

3. The aqueous composition of claim 1, wherein the poloxamine is selected from the group consisting of poloxamine 707, poloxamine 908, poloxamine 1107, poloxamine 1307 and poloxamine 1508.

4. The aqueous composition of claim 1 wherein the straight chain polyether surfactant having an HLB value greater than or equal to 18 is selected from the group consisting of poloxamer 105, poloxamer 108, poloxamer 188, poloxamer 217, poloxamer 237, poloxamer 238, poloxamer 288, poloxamer 338 and poloxamer 407.

5. The aqueous composition of claim 1, wherein the poloxamer having an HLB value less than or equal to 15 are poloxamer 403 and poloxamer 335.

6. The aqueous composition of claim 1, wherein the poloxamer having an HLB value less than or equal to 15 is present from about 0.01 weight percent to 2 weight percent.

7. The aqueous composition of claim 1, wherein the buffer agent is selected from the group consisting of borate buffers, citrate buffers, aminoalcohol buffers, Good buffers, phosphate buffers, and mixtures thereof to maintain a pH from about 6 to about 8.

12. The aqueous composition of claim 1, wherein the one or more antimicrobial agents is selected from the group consisting of 4-tris(2-hydroxyethyl) ammonio]-2-butenyl-ω

-[tris(2-hydroxyethyl)ammonio]dichloride, poly(hexamethylene biguanide) and alexidine.

14. The aqueous composition of claim 1, further comprising a wetting agent selected from the group consisting of poly(vinylpyrrolidone), hydroxypropylmethyl cellulose and propylene glycol.

16. The aqueous composition of claim 1, wherein the poloxamer having an HLB value less than or equal to 15 is present from 0.01 wt. % to 0.25 wt. %.

8. A method of cleaning lipid deposits or minimizing lipid deposition on a contact lens in the eye, the method comprising administering aqueous eye drop to the eye, the composition comprising:

(a) a poloxamine having an HLB value greater than or equal to 18; and

(b) a poloxamer having an HLB value less than or equal to 15, and is present in an amount effective to improve the lipid cleaning effect of the composition;

a straight chain polyether surfactant having an HLB value greater than or equal to 18;

one or more antimicrobial agents present in an amount effective to preserve the composition; and

a buffering agent, and an osmolality adjusting agent, wherein the osmolality adjusting agent is present to provide an osmolality of from 200 to 400 mOsm/kg.

9. The method of claim 8, wherein the weight ratio of the poloxamine to the straight chain polyether surfactant having an HLB value greater than or equal to 18 is about one to two.

13. The method of claim 8, wherein the one or more antimicrobial agents is selected from the group consisting of 4-tris(2-hydroxyethyl)ammonio]-2-butenyl-ω

-[tris(2-hydroxyethyl)ammonio]dichloride, poly(hexamethylene biguanide) and alexidine.

15. The method of claim 8, wherein the composition further comprises a wetting agent selected from the group consisting of poly(vinylpyrrolidone), hydroxypropylmethyl cellulose and propylene glycol.

17. The method of claim 8, wherein the poloxamer having an HLB value less than or equal to 15 is present from 0.01 wt. % to 0.25 wt. %.

19. The method of claim 8, wherein the poloxamer having an HLB value less than or equal to 15 is present from about 0.01 wt. %to 2 wt. %.

10. A method of cleaning lipids and/or prevent lipid deposition on a contact lens while worn on an eye comprising:

(i) soaking prior to placement on an eye contact lens in an aqueous composition comprising;

(a) a poloxamine having an HLB value greater than or equal to 18;

a straight chain polyether surfactant having an HLB value greater than or equal to 18; and

a poloxamer having an HLB value less than or equal to 15, and is present in an amount effective to improve the lipid cleaning effect of the composition, and

(ii) directly placing the treated contact lens in an eye of the wearer.

11. The method of claim 10, wherein the weight ratio of of the poloxamine to the straight chain polyether surfactant having an HLB value greater than or equal to 18 is about one to two.

18. The method of claim 10, wherein the poloxamer having an HLB value less than or equal to 15 is present from 0.01 wt. % to 0.25 wt. %.

20. The method of claim 10, wherein the poloxamer having an HLB value less than or equal to 15 is present from about 0.01 wt. %to 2 wt. %.

21. The method of claim 10, wherein the composition further comprises one or more antimicrobial agents selected from the group consisting of 4-tris(2-hydroxyethyl)ammonio]-2-butenyl-ω

-[tris(2-hydroxyethyl)ammonio]dichioride, poly(hexamethylene biguanide) and alexidine.

22. The method of claim 10, further comprising a wetting agent selected from the group consisting of poly(vinylpyrrolidone), hydroxypropylmethyl cellulose and propylene glycol.