Nanoparticles for protein drug delivery
First Claim
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1. A pharmaceutical composition of nanoparticles characterized by enhancing intestinal paracellular transport, each nanoparticle comprising a first component of at least one bioactive agent, a second component of low molecular weight chitosan, and a third component that is negatively charged, wherein said second component dominates on a surface of said nanoparticle.
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Abstract
The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
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Citations
18 Claims
- 1. A pharmaceutical composition of nanoparticles characterized by enhancing intestinal paracellular transport, each nanoparticle comprising a first component of at least one bioactive agent, a second component of low molecular weight chitosan, and a third component that is negatively charged, wherein said second component dominates on a surface of said nanoparticle.
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